A monoclonal antibody (NMC‐VIII/10) to factor VIII light chain recognizing Glu¹⁶⁷⁵–Glu¹⁶⁸⁴ inhibits factor VIII binding to endogenous von Willebrand factor in human umbilical vein endothelial cells

Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells

1973 • 1,303 citations

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

1981 • 590 citations

Antihemophilic Factor Antigen. LOCALIZATION IN ENDOTHELIAL CELLS BY IMMUNOFLUORESCENT MICROSCOPY

1973 • 449 citations

Stabilization of Factor VIII in Plasma by the von Willebrand Factor

1977 • 421 citations

The factor VIII complex: structure and function

1981 • 408 citations

Decreased adhesion of platelets to subendothelium in von Willebrand's disease.

1974 • 391 citations

Synthesis of Factor VIII Antigen by Cultured Guinea Pig Megakaryocytes

1977 • 390 citations

Synthesis, processing, and secretion of recombinant human factor VIII expressed in mammalian cells.

1988 • 385 citations

Distribution of factor VIII mRNA and antigen in human liver and other tissues

1985 • 293 citations

Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor.

1991 • 275 citations

Biosynthesis of von Willebrand protein by human megakaryocytes.

1985 • 271 citations

Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor.

1988 • 244 citations

New variant of von Willebrand disease with defective binding to factor VIII

1989 • 234 citations

Association of the factor VIII light chain with von Willebrand factor.

1988 • 223 citations

Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine

1990 • 198 citations

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

1989 • 183 citations

Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease

1982 • 180 citations

A new von Willebrand factor (vWF) defect in a patient with factor VIII (FVIII) deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF. Characterization of abnormal vWF/FVIII interaction

1990 • 152 citations

An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor.

1988 • 136 citations

Factor VIII binds to von Willebrand factor via its Mr-80000 light chain

1987 • 89 citations

von Willebrand factor is a cofactor for thrombin-catalyzed cleavage of the factor VIII light chain.

1990 • 85 citations

The ultrastructural localization of von Willebrand factor in endothelial cells.

1984 • 79 citations

Localization of the binding regions of a murine monoclonal anti-factor VIII antibody and a human anti-factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues threonine351-serine365 of the factor VIII heavy chain.

1988 • 77 citations

Inhibition of human coagulation factor VIII by monoclonal antibodies. Mapping of functional epitopes with the use of recombinant factor VIII fragments

1989 • 65 citations

Epitope localization of monoclonal antibodies against factor VIII light chain which inhibit complex formation by factor VIII with von Willebrand factor.

1991 • 28 citations

Purification of human factor VIII from a heat-treated factor VIII concentrate in the presence of potent protease inhibitors.

1987 • 2 citations