Structural basis for the decreased procoagulant activity of human factor VIII compared to the porcine homolog

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity

1981 • 4,191 citations

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Structure of human factor VIII

1984 • 898 citations

[Changes under the influence of high pressure of certain properties of myosin, actomyosin and actin].

1960 • 499 citations

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

1986 • 404 citations

Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease

1982 • 180 citations

Evidence for the formation of an ester between thrombin and heparin cofactor

1975 • 180 citations

Monoclonal antibodies to porcine factor VIII coagulant and their use in the isolation of active coagulant protein

1982 • 178 citations

Purified human factor VIII procoagulant protein: comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs.

1985 • 175 citations

The size of human factor VIII heterodimers and the effects produced by thrombin

1986 • 161 citations

pH-dependent denaturation of thrombin-activated porcine factor VIII.

1990 • 149 citations

Subunit structure of thrombin-activated porcine factor VIII

1989 • 147 citations

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies

1985 • 142 citations

Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma.

1986 • 140 citations

Thrombin proteolysis of purified factor viii procoagulant protein: correlation of activation with generation of a specific polypeptide

1983 • 123 citations

Stabilization of thrombin-activated porcine factor VIII:C by factor IXa phospholipid

1984 • 117 citations

Activation of porcine factor VIII:C by thrombin and factor Xa

1985 • 114 citations

In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma

1989 • 105 citations

The functional domains of coagulation factor VIII:C.

1986 • 87 citations

von Willebrand factor is a cofactor for thrombin-catalyzed cleavage of the factor VIII light chain.

1990 • 85 citations

Reconstitution of human factor VIII from isolated subunits

1988 • 81 citations

Characterization of recombinant human factor VIII.

1987 • 76 citations

Subunit structure of thrombin-activated human factor VIIIa

1988 • 67 citations

The activation and inactivation of human factor VIII by thrombin: effect of inhibitors of thrombin

1981 • 66 citations

The effect of thrombin on the complex between factor VIII and von Willebrand factor

1987 • 63 citations

Stoichiometry of the porcine factor VIII-von Willebrand factor association.

1987 • 59 citations

Effects of thrombin treatment of preparations of factor VIII and the Ca2+-dissociated small active fragment.

1975 • 54 citations

Molecular characterization of commercial porcine factor VIII concentrate

1988 • 45 citations

Human factor VIII: purification from commercial factor VIII concentrate, characterization, identification and radiolabeling

1986 • 36 citations