Renal Transporters for Organic Anions and Organic Cations. Structural Requirements for Substrates

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Hydrogen bonding in biological structures

1992 • 2,400 citations

The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping

1994 • 751 citations

Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide.

1996 • 576 citations

Expression cloning of a rat liver Na(+)-independent organic anion transporter.

1994 • 535 citations

cDNA Cloning and Functional Expression of a Novel Rat Kidney Organic Cation Transporter, OCT2

1996 • 353 citations

Vesicular neurotransmitter transporters: from bacteria to humans.

1995 • 319 citations

Secretion of organic anions in the formation of urine and bile.

1959 • 262 citations

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

1996 • 262 citations

Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney

1997 • 256 citations

Cloning and Functional Characterization of a Novel Rat Organic Anion Transporter Mediating Basolateral Uptake of Methotrexate in the Kidney

1996 • 199 citations

Immunologic distribution of an organic anion transport protein in rat liver and kidney

1996 • 182 citations

Specificity of transporters for ‘organic anions’ and ‘organic cations’ in the kidney

1994 • 172 citations

Sequence and Functional Characterization of a Renal Sodium/Dicarboxylate Cotransporter

1995 • 167 citations

Indirect coupling to Na+ of p-aminohippuric acid uptake into rat renal basolateral membrane vesicles

1987 • 142 citations

The choroid plexus epithelium is the site of the organic anion transport protein in the brain

1997 • 140 citations

Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions

1988 • 115 citations

Rat intestinal fatty acid binding protein. A model system for analyzing the forces that can bind fatty acids to proteins.

1993 • 112 citations

Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.

1997 • 110 citations

Specificity of the transport system for tricarboxylic acid cycle intermediates in renal brush borders

1980 • 108 citations

Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles

1988 • 108 citations

A definition of substrate specificity in renal transport of organic anions

1965 • 106 citations

Secretion and contraluminal uptake of dicarboxylic acids in the proximal convolution of rat kidney

1984 • 86 citations

Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems

1993 • 86 citations

Sodium-dependent dicarboxylate transport in rat renal basolateral membrane vesicles

1984 • 83 citations

Molecular Cloning and Functional Reconstitution of a Urate Transporter/Channel

1997 • 79 citations

Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump

1990 • 77 citations

Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney

1987 • 75 citations

Contraluminal transport of organic cations in the proximal tubule of the rat kidney

1991 • 71 citations

Bisubstrates: substances that interact with both, renal contraluminal organic anion and organic cation transport systems

1993 • 68 citations

Anion transport through the contraluminal cell membrane of renal proximal tubule. The influence of hydrophobicity and molecular charge distribution on the inhibitory activity of organic anions

1989 • 65 citations

A choline transporter in renal brush-border membrane vesicles: Energetics and structural specificity

1992 • 62 citations

Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney

1989 • 60 citations

Contraluminal organic anion and cation transport in the proximal renal tubule: V. Interaction with sulfamoyl- and phenoxy diuretics, and with β-lactam antibiotics

1989 • 60 citations

Reabsorption of dicarboxylic acids from the proximal convolution of rat kidney

1983 • 54 citations

The structure of porin from Paracoccus denitrificans at 3.1 Å resolution

1997 • 51 citations

Contraluminal para-aminohippurate transport in the proximal tubule of the rat kidney

1987 • 49 citations

Inhibition of Mouse Erythroid Band 3-Mediated Chloride Transport by Site-Directed Mutagenesis of Histidine Residues and Its Reversal by Second Site Mutation of Lys 558, the Locus of Covalent H2DIDS Binding

1995 • 48 citations

Luminal transport system for H+/organic cations in the rat proximal tubule

1995 • 46 citations

Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney

1987 • 45 citations

Organic anion transport across the contraluminal membrane—Dependence on sodium

1989 • 45 citations

Contraluminal sulfate transport in the proximal tubule of the rat kidney

1985 • 45 citations

Contraluminal sulfate transport in the proximal tubule of the rat kidney

1985 • 44 citations

Kinetic studies on the competition between famotidine and cimetidine in rats. Evidence of multiple renal secretory systems for organic cations.

1988 • 40 citations

Structure and interaction of inhibitors with the TEA/H+ exchanger of rabbit renal brush border membranes

1995 • 39 citations

The Liver-like Anion Transport System in Rabbit Kidney, Uvea and Choroid Plexus. II. Efficiency of Acidic Drugs and Other Anions as Inhibitors

1973 • 38 citations

Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney

1988 • 37 citations

Contraluminal sulfate transport in the proximal tubule of the rat kidney

1985 • 34 citations

Organic anion transport in macrophage membrane vesicles.

1990 • 33 citations

Luminal transport system for choline+ in relation to the other organic cation transport systems in the rat proximal tubule

1996 • 33 citations

Substrate specificity of the luminal Na+-dependent sulphate transport system in the proximal renal tubule as compared to the contraluminal sulphate exchange system

1992 • 32 citations

Interaction of Alkyl/Arylphosphonates, phosphonocarboxylates and diphosphonates with different anion transport systems in the proximal renal tubule.

1997 • 28 citations

Transport of organic cations in brush border membrane vesicles from rabbit kidney cortex

1986 • 28 citations

Pathways for carboxylic acid transport by rabbit renal brush border membrane vesicles

1982 • 28 citations

Role of the conserved quartets of residues located in the N- and C-terminal halves of the transposon Tn10-encoded metal-tetracycline/hydrogen ion antiporter of Escherichia coli

1993 • 27 citations

Contraluminal sulfate transport in the proximal tubule of the rat kidney

1985 • 26 citations

Contraluminal p-aminohippurate transport in the proximal tubule of the rat kidney

1991 • 23 citations

Isolation and immunolocalization of a rat renal cortical membrane urate transporter.

1994 • 23 citations

Polysubstrates: substances that interact with renal contraluminal PAH, sulfate, and NMeN transport: sulfamoyl-, sulfonylurea-, thiazide- and benzeneamino-carboxylate (nicotinate) compounds.

1994 • 19 citations

Characteristics of uptake of short chain fatty acids by luminal membrane vesicles from rabbit kidney

1986 • 18 citations

Stereospecificity in contraluminal and luminal transporters of organic cations in the rat renal proximal tubule.

1996 • 15 citations

Characterization of sodium and pyruvate interactions of the two carrier systems specific of mono- and di- or tricarboxylic acids by renal brush-border membrane vesicles

1989 • 13 citations

Morphine Analogues: Relationship between Chemical Structure and Interaction with Proximal Tubular Transporters – Contraluminal Organic Cation and Anion Transporter, Luminal H<sup>+</sup> /Organic Cation Exchanger, and Luminal Choline Transporter

1995 • 11 citations

Interaction of Diuretics with Transport Systems in the Proximal Renal Tubule

1995 • 7 citations

Transport of Organic Molecules

1991 • 4 citations

Substrate specificity of urate transporter in rat renal brush border membranes

1991 • 3 citations

Fura-2 transport in toad urinary bladder epithelium: effects of antidiuretic hormone, colchicine and osmotic gradients

1993 • 3 citations

AFFINITY LABELS AS SUBSTRATES FOR THE ANION TRANSPORT SYSTEMS AT THE CONTRALUMINAL CELL SIDE OF THE RENAL PROXIMAL TUBULE

1987 • 3 citations