MDMA (Ecstasy) neurotoxicity: assessing and communicating the risks

Reconciling the role of central serotonin neurons in human and animal behavior

1986 • 989 citations

Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings

1998 • 673 citations

Advances in Drug Research

1964 • 615 citations

Recreational MDMA use in Sydney: a profile of ‘Ecstasy’ users and their experiences with the drug

1992 • 427 citations

Memory impairment in abstinent MDMA ("Ecstasy") users

1998 • 381 citations

Ecstasy use in Australia: patterns of use and associated harm

1999 • 362 citations

Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance

1998 • 351 citations

Small Changes in Ambient Temperature Cause Large Changes in 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonin Neurotoxicity and Core Body Temperature in the Rat

1998 • 345 citations

Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (±)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery

1999 • 340 citations

Serotonin Neurotoxicity after (±)3,4-Methylenedioxymethamphetamine (MDMA; “Ecstasy”): A Controlled Study in Humans

1994 • 336 citations

Cognitive performance in (±) 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users: a controlled study

1999 • 305 citations

Recreational Use of “Ecstasy” (MDMA) Is Associated with Elevated Impulsivity

1998 • 293 citations

Memory deficits associated with recreational use of "ecstasy" (MDMA)

1999 • 287 citations

Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA (‘ecstasy’) users

1999 • 286 citations

Mood and cognitive effects of ± 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’): week‐end ‘high’ followed by mid‐week low

1997 • 286 citations

Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")

1995 • 268 citations

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

1988 • 255 citations

Cognitive performance in recreational users of MDMA or 'ecstasy': evidence for memory deficits

1998 • 227 citations

MDMA (`ecstasy') consumption in the context of polydrug abuse: a report on 150 patients

1998 • 221 citations

An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine.

1998 • 183 citations

3,4-Methylenedioxy analogues of amphetamine: Defining the risks to humans

1999 • 182 citations

Serotonergic function after (±)3,4-methylene-dioxymethamphetarnine (‘Ecstasy’) in humans

1998 • 146 citations

In vivo detection of short- and long-term MDMA neurotoxicity?a positron emission tomography study in the living baboon brain

1998 • 143 citations

Long-lasting effects of (±)3,4-methylene-dioxymethamphetamine (Ecstasy) on serotonin system function in humans

2000 • 143 citations

Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression

1998 • 133 citations

Persistent Effects of (±)3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) on Human Sleep

1993 • 116 citations

Aminergic Metabolites in Cerebrospinal Fluid of Humans Previously Exposed to MDMA: Preliminary Observations^a

1990 • 106 citations

Extrapolation of Toxicological and Pharmacological Data from Animals to Humans

1991 • 104 citations

Behavioural analysis of the acute and chronic effects of MDMA treatment in the rat

1999 • 102 citations

Level of use of 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in humans correlates with EEG power and coherence

1999 • 96 citations

Neuroendocrine and Mood Responses to Intravenous L-Tryptophan in 3,4-Methylenedioxymethamphetamine (MDMA) Users

1989 • 92 citations

Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence.

1997 • 91 citations

Ecstasy – long-term effects on the human central nervous system revealed by positron emission tomography

1999 • 86 citations

Altered neuroendocrine and behavioral responses to m -chlorophenylpiperazine in 3,4-methylenedioxymethamphetamine (MDMA) users

1999 • 86 citations

Studies on the role of dopamine in the degeneration of 5‐HT nerve endings in the brain of Dark Agouti rats following 3,4‐methylenedioxymethamphetamine (MDMA or ‘ecstasy’) administration

1999 • 84 citations

Brain Serotonin Neurotoxicity and Primary Pulmonary Hypertension From Fenfluramine and Dexfenfluramine

1997 • 67 citations

Persistent loss of thermoregulation in the rat induced by 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") but not by fenfluramine

1998 • 65 citations

The Love Drug: Marching to the Beat of Ecstasy

1998 • 62 citations

Mood and cognitive effects of 6 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy'): week-end 'high' followed by mid-week low

1997 • 58 citations

Effects of MDMA on Complex Brain Function in Laboratory Animals

1997 • 57 citations

Reinforcing Subjective Effects of (??) 3,4-Methylenedioxymethamphetamine (???Ecstasy???) May Be Separable from its Neurotoxic Actions

1993 • 54 citations

The love drug: marching to the beat of ecstasy

1999 • 49 citations

Cardiovascular autonomic dysregulation in users of MDMA ("Ecstasy")

1998 • 32 citations