Helix 8 of the Leukotriene B4 Receptor Is Required for the Conformational Change to the Low Affinity State after G-protein Activation

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1999 • 1,479 citations

GABAB-receptor subtypes assemble into functional heteromeric complexes

1998 • 1,163 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Using known substructures in protein model building and crystallography.

1986 • 766 citations

A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization

2000 • 666 citations

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)^,

2001 • 598 citations

Arachidonic Acid Cascade and Signal Transduction

1990 • 597 citations

GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid

1998 • 568 citations

A Second Leukotriene B4 Receptor, Blt2

2000 • 539 citations

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors

1997 • 502 citations

Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors

2001 • 446 citations

Lipid mediator networks in cell signaling: update and impact of cytokines ¹

1996 • 401 citations

GABAB receptors – the first 7TM heterodimers

1999 • 345 citations

Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

1999 • 323 citations

C-Terminal Interaction Is Essential for Surface Trafficking But Not for Heteromeric Assembly of GABA_BReceptors

2001 • 299 citations

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

2003 • 281 citations

A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Orphan G-protein-coupled receptors and natural ligand discovery

2001 • 272 citations

Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor

1996 • 230 citations

Bltr Mediates Leukotriene B4–Induced Chemotaxis and Adhesion and Plays a Dominant Role in Eosinophil Accumulation in a Murine Model of Peritonitis

2000 • 198 citations

Defects in G Protein-Coupled Signal Transduction in Human Disease

1996 • 196 citations

Principles: Extending the utility of [35S]GTPγS binding assays

2003 • 186 citations

Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor–Induced Anaphylaxis

2000 • 177 citations

Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems

2001 • 173 citations

Seven-transmembrane receptors: crystals clarify

2002 • 158 citations

A Dileucine Sequence and an Upstream Glutamate Residue in the Intracellular Carboxyl Terminus of the Vasopressin V₂Receptor Are Essential for Cell Surface Transport in COS.M6 Cells

1998 • 145 citations

The Amino Terminus of the Fourth Cytoplasmic Loop of Rhodopsin Modulates Rhodopsin-Transducin Interaction

2000 • 133 citations

Characterization of the Phosphorylation Sites Involved in G Protein-coupled Receptor Kinase- and Protein Kinase C-mediated Desensitization of the α1B-Adrenergic Receptor

1997 • 123 citations

Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.

1982 • 122 citations

Structure and Function in Rhodopsin: Mapping Light-Dependent Changes in Distance between Residue 316 in Helix 8 and Residues in the Sequence 60−75, Covering the Cytoplasmic End of Helices TM1 and TM2 and Their Connection Loop CL1

2001 • 100 citations

Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization.

1992 • 98 citations

Structure and Function in Rhodopsin: Mapping Light-Dependent Changes in Distance between Residue 65 in Helix TM1 and Residues in the Sequence 306−319 at the Cytoplasmic End of Helix TM7 and in Helix H8

2001 • 96 citations

Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C‐terminus

1998 • 71 citations

Agonist-induced Sequestration, Recycling, and Resensitization of Platelet-activating Factor Receptor

1998 • 62 citations

Threonine 308 within a Putative Casein Kinase 2 Site of the Cytoplasmic Tail of Leukotriene B4 Receptor (BLT1) Is Crucial for Ligand-induced, G-protein-coupled Receptor-specific Kinase 6-mediated Desensitization

2002 • 56 citations

Agonist-induced Internalization of the Platelet-activating Factor Receptor Is Dependent on Arrestins but Independent of G-protein Activation

2002 • 55 citations

Signalling through the leukotriene B4 receptor involves both αi and α16, but not αq or α11 G-protein subunits

1998 • 54 citations

Cloning and Characterization of Rat Leukotriene B4 Receptor

1999 • 48 citations

Structural Requirements for the Stabilization of Metarhodopsin II by the C Terminus of the α subunit of Transducin

2001 • 47 citations

Leukotriene B₄ Receptor

2000 • 41 citations

cDNA cloning and characterization of guinea-pig leukotriene B4 receptor

1999 • 36 citations

Protein kinase C regulates leukotriene B₄ receptors in human neutrophils

1986 • 22 citations

Receptor-dependent Metabolism of Platelet-activating Factor in Murine Macrophages

2002 • 21 citations

Mont Sainte‐Odile: a sanctuary for GPCRs

2003 • 12 citations

Protein kinase C impairs the coupling of the GTP-binding protein to LTB4 receptor in neutrophil

1992 • 6 citations