QSAR and Molecular Modelling of Catamphiphilic Drugs Able to Modulate Multidrug Resistance in Tumors

Genetic algorithms as a strategy for feature selection

1992 • 771 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

1989 • 233 citations

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1989 • 217 citations

Application of a genetic algorithm to feature selection under full validation conditions and to outlier detection

1994 • 199 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Reversal of multidrug resistance by phenothiazines and structurally related compounds

1992 • 114 citations

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

1992 • 111 citations

Drug Membrane Interaction and the Importance for Drug Transport, Distribution, Accumulation, Efficacy and Resistance

1994 • 86 citations

Resistance to Antineoplastic Drugs

1990 • 81 citations

Structural characteristics of compounds that modulate P-glycoprotein-associated multidrug resistance

1990 • 78 citations

Modulators of Multidrug Resistance: Preclinical Studies

1995 • 78 citations

Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability

1996 • 69 citations

Comparative Molecular Field Analysis of the Antitumor Activity of 9H-Thiioxanthen-9-one Derivatives against Pancreatic Ductal Carcinoma 03

1994 • 47 citations

The Importance of Drug‐Membrane Interaction in Drug Research and Development

1992 • 43 citations

Structure-activity study and design of multidrug-resistant reversal compounds by a computer automated structure evaluation methodology.

1992 • 41 citations

The reversal of multidrug resistance in cancer (review).

1993 • 24 citations

Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists

1993 • 24 citations

Annual reports on NMR spectroscopy

1991 • 16 citations

Quantitative structure-activity relationships for calmodulin inhibitors.

1990 • 15 citations

Binding of Drugs and ATP by P-Glycoprotein and Transport of Drugs by Vesicles from Human Multidrug-Resistant Cells

1991 • 13 citations

Structural changes by sulfoxidation of phenothiazine drugs

1992 • 10 citations

Molecular structure and dynamics of cis(Z)-and trans(E)-flupenthixol and clopenthixol.

1991 • 9 citations

Molecular modeling of antipsychotic drugs and G protein coupled receptors.

1991 • 5 citations