Prevention of sudden cardiac death by n−3 polyunsaturated fatty acids

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

Preliminary Report: Effect of Encainide and Flecainide on Mortality in a Randomized Trial of Arrhythmia Suppression after Myocardial Infarction

1989 • 3,227 citations

EFFECTS OF CHANGES IN FAT, FISH, AND FIBRE INTAKES ON DEATH AND MYOCARDIAL REINFARCTION: DIET AND REINFARCTION TRIAL (DART)

1989 • 2,639 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction

2002 • 1,317 citations

Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death

2002 • 1,147 citations

Fish Consumption and Risk of Sudden Cardiac Death

1998 • 1,002 citations

Dietary Intake and Cell Membrane Levels of Long-Chain n-3 Polyunsaturated Fatty Acids and the Risk of Primary Cardiac Arrest

1995 • 911 citations

Molecular Determinants of State-Dependent Block of Na ⁺ Channels by Local Anesthetics

1994 • 829 citations

Omega 3 Fatty Acids in Bipolar Disorder

1999 • 815 citations

Clinical Prevention of Sudden Cardiac Death by n-3 Polyunsaturated Fatty Acids and Mechanism of Prevention of Arrhythmias by n-3 Fish Oils

2003 • 617 citations

Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis.

1980 • 513 citations

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.

1996 • 488 citations

Amphipathic metabolites and membrane dysfunction in ischemic myocardium.

1984 • 445 citations

Baroreceptor reflex control of heart rate: a predictor of sudden cardiac death.

1982 • 429 citations

Ankyrin and spectrin associate with voltage-dependent sodium channels in brain

1988 • 415 citations

Lack of benefit of dietary advice to men with angina: results of a controlled trial

2003 • 415 citations

Prevention of Sudden Cardiac Death by Dietary Pure ω-3 Polyunsaturated Fatty Acids in Dogs

1999 • 404 citations

Suppression of voltage-gated L-type Ca ²⁺ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes

1997 • 384 citations

Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion

1988 • 334 citations

Energetics of Inclusion-Induced Bilayer Deformations

1998 • 332 citations

Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes.

1995 • 327 citations

Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons.

1996 • 299 citations

Actin filaments regulate epithelial Na+ channel activity

1991 • 283 citations

Membrane Stiffness and Channel Function

1996 • 280 citations

Prevention of ischemia-induced ventricular fibrillation by omega 3 fatty acids.

1994 • 254 citations

Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats

1993 • 252 citations

A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis

1992 • 247 citations

Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes.

1994 • 237 citations

Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes.

1995 • 229 citations

Do fish oils prevent restenosis after coronary angioplasty?

1994 • 228 citations

Engineering the Gramicidin Channel

1996 • 215 citations

Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids.

1992 • 211 citations

External blockade of the major cardiacdelayed-rectifier K+ channel (Kv1.5) by polyunsaturated fattyacids.

1994 • 200 citations

Prevention of ischemia‐induced cardiac Sudden death by n−3 polyunsaturated fatty acids in dogs

1997 • 196 citations

A new era for science in nutrition

1987 • 193 citations

Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey

1992 • 190 citations

Spring Constants for Channel-Induced Lipid Bilayer Deformations Estimates Using Gramicidin Channels

1999 • 187 citations

Evidence that free polyunsaturated fatty acids modify Na+ channels by directly binding to the channel proteins.

1996 • 185 citations

Fatty acids suppress voltage-gated Na ⁺ currents in HEK293t cells transfected with the α-subunit of the human cardiac Na ⁺ channel

1998 • 182 citations

Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics.

1984 • 176 citations

LIPID DOMAINS IN MEMBRANES*

1982 • 155 citations

Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model

1998 • 147 citations

Lipid Bilayer Electrostatic Energy, Curvature Stress, and Assembly of Gramicidin Channels

1997 • 146 citations

Influence of dietary lipids on arrhythmias and infarction after coronary artery ligation in rats

1985 • 137 citations

The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia.

1991 • 125 citations

Single point mutations affect fatty acid block of human myocardial sodium channel α subunit Na ⁺ channels

2001 • 124 citations

Differential Effects of Various Eicosanoids on the Production or Prevention of Arrhythmias in Cultured Neonatal Rat Cardiac Myocytes

1997 • 119 citations

Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes

1996 • 118 citations

A mutation in segment I-S6 alters slow inactivation of sodium channels

1997 • 114 citations

Prevention and Termination of β-Adrenergic Agonist-Induced Arrhythmias by Free Polyunsaturated Fatty Acids in Neonatal Rat Cardiac Myocytes

1995 • 102 citations

Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes

2001 • 99 citations

[10] Ion channels as tools to monitor lipid bilayer-membrane protein interactions: Gramicidin channels as molecular force transducers

1999 • 98 citations

Ca2+-Mg2+ ATPase of Mouse Cardiac Sarcoplasmic Reticulum is Affected by Membrane n-6 and n-3 Polyunsaturated Fatty Acid Content

1989 • 96 citations

Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion

1990 • 96 citations

Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics.

1998 • 87 citations

The Antiarrhythmic and Anticonvulsant Effects of Dietary N-3 Fatty Acids

1999 • 83 citations

Coexpression with β₁-subunit modifies the kinetics and fatty acid block of hH1_αNa⁺channels

2000 • 79 citations

A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated μ1 Na + channels

1997 • 75 citations

Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel alpha subunit in rat cardiac muscle.

1992 • 74 citations

Polyunsaturated fatty acids exert antiarrhythmic actions as free acids rather than in phospholipids

1996 • 72 citations

EFFECT OF FATTY ACIDS ON THE VENTRICULAR ARRHYTHMIA THRESHOLD IN THE ISOLATED HEART OF THE RABBIT

1981 • 65 citations

Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle

2000 • 64 citations

Dietary fish oil supplementation attenuates myocardial dysfunction and injury caused by global ischemia and reperfusion in isolated rat hearts.

1993 • 63 citations

Electrocardiographic subset analysis of diltiazem administration on long-term outcome after acute myocardial infarction

1991 • 60 citations

THE ROLE OF MYOCARDIAL MEMBRANE LIPIDS IN THE DEVELOPMENT OF CARDIAC NECROSIS

1976 • 59 citations

Lysophosphoglycerides and ventricular fibrillation early after onset of ischemia

1987 • 58 citations

Regulation of sodium channel gene expression by class I antiarrhythmic drugs and n − 3 polyunsaturated fatty acids in cultured neonatal rat cardiac myocytes

1997 • 57 citations

Antiarrhythmic Effects of Eicosapentaenoic Acid during Myocardial Infarction. Enhanced Cardiac Microsomal (Ca2+-Mg2+)-ATPase Activity.

1994 • 54 citations

The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to ω3 polyunsaturated fatty acids

1998 • 52 citations

Gramicidin channels in phospholipid bilayers with unsaturated acyl chains

1997 • 44 citations

The Modulation of Ionic Currents in Excitable Tissues by n-3 Polyunsaturated Fatty Acids

2001 • 42 citations

Sodium channel inactivation from closed states: evidence for an intrinsic voltage dependency

1995 • 32 citations

Dietary fish oil prevents reperfusion Ins(1,4,5)P3 release in rat heart: possible antiarrhythmic mechanism

1996 • 29 citations

Protective Effects of All-Trans-Retinoic Acid Against Cardiac Arrhythmias Induced by Isoproterenol, Lysophosphatidylcholine or Ischemia and Reperfusion

1995 • 28 citations

Effects of polyunsaturated fatty acids on cardiac voltage-activated K(+) currents in adult ferret cardiomyocytes .

2002 • 25 citations

Binding of Fatty Acids to Albumin: A Case Study of Lipid-Protein Interactions

1992 • 10 citations

Cardiac Ca²⁺Regulation and the Tuna Fish Sandwich

2002 • 9 citations