Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Quantitative studies on some antagonists of N‐methyl D‐aspartate in slices of rat cerebral cortex

1985 • 487 citations

[³H]MK‐801 Labels a Site on the N‐Methyl‐D‐Aspartate Receptor Channel Complex in Rat Brain Membranes

1988 • 453 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

Sigma and phencyclidine-like compounds as molecular probes in biology

1988 • 251 citations

Repeated administration of MK-801 produces sensitization to its own locomotor stimulant effects but blocks sensitization to amphetamine

1991 • 238 citations

Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.

1986 • 187 citations

Phencyclidine and related drugs bind to the activated receptor-channel complex in rat brain membranes

1987 • 170 citations

Neuropharmacology of Phencyclidine: Basic Mechanisms and Therapeutic Potential

1990 • 160 citations

Acute and chronic phencyclidine effects on locomotor activity, stereotypy and ataxia in rats

1981 • 141 citations

Typical and atypical neuroleptics antagonize MK-801-induced locomotion and stereotypy in rats

1992 • 122 citations

Phencyclidine-induced rotational behavior in rats with nigrostriatal lesions and its modulation by dopaminergic and cholinergic agents

1976 • 89 citations

Increases in extracellular dopamine levels and locomotor activity after direct infusion of phencyclidine into the nucleus accumbens

1992 • 85 citations

Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine

1987 • 70 citations

Behavioral sensitization to MK-801 (dizocilpine)

1993 • 67 citations

Acute and chronic behavioral interactions between phencyclidine (PCP) and amphetamine: Evidence for a dopaminergic role in some PCP-induced behaviors

1985 • 66 citations

Behavioral effects of chronic phencyclidine administration in rats

1982 • 60 citations

Phencyclidine-induced behavioral sensitization

1994 • 57 citations

Selective mechanism-based inactivation of the major phenobarbital-inducible P-450 cytochrome from rabbit liver by phencyclidine and its oxidation product, the iminium compound.

1989 • 32 citations

Evidence for multiple opiate receptor involvement in different phencyclidine-induced unconditioned behaviors in rats

1986 • 30 citations

Comparison of the pharmacologic effects of N-allylnormetazocine and phencyclidine: Sensitization, cross-sensitization, and opioid antagonist activity

1986 • 24 citations

The anticonvulsant and behavioral effects of phencyclidine and ketamine following chronic treatment in rats

1986 • 21 citations

Effects of chronic administration of phencyclidine on stereotyped and ataxic behaviors in the rat

1981 • 15 citations