In Vivo Light-induced and Basal Phospholipase C Activity in Drosophila Photoreceptors Measured with Genetically Targeted Phosphatidylinositol 4,5-Bisphosphate-sensitive Ion Channels (Kir2.1)

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

1999 • 1,456 citations

The trp ion channel family

2001 • 1,108 citations

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

1998 • 886 citations

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

1998 • 733 citations

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

1992 • 732 citations

Abnormal Electroretinogram from a Drosophila Mutant

1969 • 642 citations

Altered Electrical Properties inDrosophilaNeurons Developing without Synaptic Transmission

2001 • 608 citations

TRP Channel Proteins and Signal Transduction

2002 • 571 citations

Spatiotemporal Dynamics of Inositol 1,4,5-Trisphosphate That Underlies Complex Ca ²⁺ Mobilization Patterns

1999 • 500 citations

Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL

1999 • 400 citations

Alterations in Conserved Kir Channel-PIP2 Interactions Underlie Channelopathies

2002 • 388 citations

The Drosophila Light-Activated Conductance Is Composed of the Two Channels TRP and TRPL

1996 • 368 citations

A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids.

1995 • 349 citations

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions

1999 • 346 citations

Voltage‐dependent inactivation of inward‐rectifying single‐channel currents in the guinea‐pig heart cell membrane.

1984 • 271 citations

Monitoring Agonist-induced Phospholipase C Activation in Live Cells by Fluorescence Resonance Energy Transfer

2001 • 237 citations

Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization

2000 • 228 citations

The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD.

1996 • 212 citations

Regulation of TRP Channels via Lipid Second Messengers

2003 • 205 citations

Specificity of activation by phosphoinositides determines lipid regulation of Kir channels

2003 • 201 citations

Calcium Influx via TRP Channels Is Required to Maintain PIP2 Levels in Drosophila Photoreceptors

2001 • 195 citations

Distinct Specificities of Inwardly Rectifying K+Channels for Phosphoinositides

1999 • 193 citations

Whole-cell recordings of the light induced current in dissociated Drosophila photoreceptors: evidence for feedback by calcium permeating the light-sensitive channels

1991 • 192 citations

In Vivo Analysis of the Drosophila Light-Sensitive Channels, TRP and TRPL

1997 • 189 citations

Gqα protein function in vivo: Genetic dissection of its role in photoreceptor cell physiology

1995 • 179 citations

Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells

1998 • 172 citations

Constitutive Activity of the Light-Sensitive Channels TRP and TRPL in the Drosophila Diacylglycerol Kinase Mutant, rdgA

2000 • 168 citations

Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats.

1993 • 155 citations

Molecular, Biochemical, and Electrophysiological Characterization of Drosophila norpA Mutants

1996 • 150 citations

Single photon responses in Drosophila photoreceptors and their regulation by Ca²⁺

2000 • 145 citations

Regulation of Drosophila transient receptor potential‐like (TrpL) channels by phospholipase C‐dependent mechanisms

2001 • 135 citations

Molecular Basis of Amplification in Drosophila Phototransduction

2002 • 112 citations

Metabolic Stress Reversibly Activates theDrosophilaLight-Sensitive Channels TRP and TRPLIn Vivo

2000 • 89 citations

Spontaneous activation of light-sensitive channels in Drosophila photoreceptors.

1994 • 68 citations

Functional equivalence of native light-sensitive channels in the Drosophila trp301 mutant and TRPL cation channels expressed in a stably transfected Drosophila cell line

1997 • 63 citations

G Protein Control of Drosophila Photoreceptor Phospholipase C

1995 • 52 citations

Structural Determinants of Gating in Inward-Rectifier K+ Channels

1999 • 47 citations

Rescue of Light Responses in the Drosophila “Null” Phospholipase C Mutant, norpA, by the Diacylglycerol Kinase Mutant, rdgA, and by Metabolic Inhibition

2003 • 44 citations

Inhibition of acetylcholine‐activated K⁺ currents by U73122 is mediated by the inhibition of PIP₂‐channel interaction

2001 • 39 citations

Activation of the Drosophila TRP and TRPL channels requires both Ca2+ and protein dephosphorylation

2003 • 28 citations

Effects of intracellular Ca2+ chelation on the light response in Drosophila photoreceptors

1995 • 23 citations