Prostaglandin E suppression of platelet-derived-growth-factor-induced Ito cell mitogenesis occurs independent of raf perinuclear translocation and nuclear proto-oncogene expression

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins.

1989 • 473 citations

A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gel

1989 • 466 citations

Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors.

1989 • 401 citations

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

1992 • 370 citations

Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.

1991 • 248 citations

Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis.

1992 • 230 citations

Early transcriptional events in cell growth

1990 • 192 citations

In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion

1989 • 175 citations

Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production.

1990 • 150 citations

The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone

1988 • 140 citations

Bradykinin inhibition of EGF- and PDGF-induced DNA synthesis in human fibroblasts

1993 • 139 citations

Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β

1989 • 136 citations

Transforming growth factor β responsiveness is modulated by the extracellular collagen matrix during hepatic ito cell culture

1988 • 125 citations

Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells

1991 • 112 citations

The Differential Effect of Prostaglandin E2 on Transforming Growth Factor-β and Insulin-induced Collagen Formation in Lung Fibroblasts

1989 • 110 citations

The effect of retinol on ito cell proliferation in vitro

1988 • 93 citations

Regulation of Epidermal Growth Factor Receptor Gene Expression by Retinoic Acid and Epidermal Growth Factor

1989 • 89 citations

An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter.

1991 • 67 citations

Transforming growth factor-β stimulation of lung fibroblast prostaglandin E2 production

1989 • 66 citations

Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

1991 • 60 citations

Regulation of Mesangial Cell Proliferation

1991 • 58 citations

16,16-dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver

1988 • 57 citations

Phenotypical modulation of liver fat-storing cells by retinoids

1992 • 52 citations

Administration of prostaglandin E1 analog reduces rat hepatic and ito cell collagen gene expression and collagen accumulation after bile duct ligation injury

1993 • 40 citations

Probing structure and function of the raf protein kinase domain with monoclonal antibodies.

1990 • 35 citations