Un Ménage à Quatre

The double-strand-break repair model for recombination

1983 • 2,468 citations

To err (meiotically) is human: the genesis of human aneuploidy

2001 • 2,344 citations

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

1999 • 2,095 citations

Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family

1997 • 1,751 citations

The Cell in Development and Heredity

1925 • 1,750 citations

Cohesins: Chromosomal Proteins that Prevent Premature Separation of Sister Chromatids

1997 • 1,466 citations

A mechanism for gene conversion in fungi

1964 • 1,459 citations

A mechanism for gene conversion in fungi

2007 • 1,149 citations

Chromosome Studies on Normal and Leukemic Human Leukocytes

1960 • 1,051 citations

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

1999 • 929 citations

An atypical topoisomerase II from archaea with implications for meiotic recombination

1997 • 890 citations

A Direct Link between Sister Chromatid Cohesion and Chromosome Condensation Revealed through the Analysis of MCD1 in S. cerevisiae

1997 • 829 citations

Meiotic chromosomes: it takes two to tango

1997 • 810 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis

1999 • 801 citations

Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast

2000 • 799 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis

1998 • 775 citations

The Mouse Spo11 Gene Is Required for Meiotic Chromosome Synapsis

2000 • 772 citations

Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections

2002 • 725 citations

A Central Role for Cohesins in Sister Chromatid Cohesion, Formation of Axial Elements, and Recombination during Yeast Meiosis

1999 • 722 citations

Molecular Architecture of SMC Proteins and the Yeast Cohesin Complex

2002 • 718 citations

Two Distinct Pathways Remove Mammalian Cohesin from Chromosome Arms in Prophase and from Centromeres in Anaphase

2000 • 698 citations

The Murine SCP3 Gene Is Required for Synaptonemal Complex Assembly, Chromosome Synapsis, and Male Fertility

2000 • 690 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

Chromosome Synapsis Defects and Sexually Dimorphic Meiotic Progression in Mice Lacking Spo11

2000 • 684 citations

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae

1990 • 683 citations

Differential Timing and Control of Noncrossover and Crossover Recombination during Meiosis

2001 • 679 citations

The Single-End Invasion

2001 • 658 citations

Phospho-Regulation of Kinetochore-Microtubule Attachments by the Aurora Kinase Ipl1p

2002 • 612 citations

Yeast Cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication

1999 • 608 citations

ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis

1993 • 606 citations

Requirement of Heterochromatin for Cohesion at Centromeres

2001 • 603 citations

Identification of Xenopus SMC protein complexes required for sister chromatid cohesion

1998 • 594 citations

An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast

1998 • 594 citations

Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells

2001 • 556 citations

Chromosomal passengers and the (aurora) ABCs of mitosis

2001 • 535 citations

Double-strand breaks at an initiation site for meiotic gene conversion

1989 • 533 citations

Cohesin Rec8 is required for reductional chromosome segregation at meiosis

1999 • 528 citations

The spindle checkpoint: structural insights into dynamic signalling

2002 • 526 citations

Extensive 3′-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site

1991 • 525 citations

Identification of double holliday junctions as intermediates in meiotic recombination

1995 • 482 citations

Interhomolog Bias during Meiotic Recombination: Meiotic Functions Promote a Highly Differentiated Interhomolog-Only Pathway

1997 • 461 citations

Chromosome segregation and cancer: cutting through the mystery

2001 • 459 citations

Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast

2001 • 453 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

Cohesion between sister chromatids must be established during DNA replication

1998 • 451 citations

The Dissociation of Cohesin from Chromosomes in Prophase Is Regulated by Polo-like Kinase

2002 • 440 citations

Disjunction of Homologous Chromosomes in Meiosis I Depends on Proteolytic Cleavage of the Meiotic Cohesin Rec8 by Separin

2000 • 425 citations

Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase

2000 • 412 citations

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

1999 • 404 citations

Dual Inhibition of Sister Chromatid Separation at Metaphase

2001 • 403 citations

A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes.

1992 • 397 citations

Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy.

1992 • 385 citations

Condensin and cohesin display different arm conformations with characteristic hinge angles

2002 • 377 citations

Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosis

1994 • 374 citations

The Symmetrical Structure of Structural Maintenance of Chromosomes (SMC) and MukB Proteins: Long, Antiparallel Coiled Coils, Folded at a Flexible Hinge

1998 • 372 citations

Phosphorylation of the Cohesin Subunit Scc1 by Polo/Cdc5 Kinase Regulates Sister Chromatid Separation in Yeast

2001 • 354 citations

Securin Is Required for Chromosomal Stability in Human Cells

2001 • 351 citations

Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers

1980 • 351 citations

Physical and Functional Interactions among Basic Chromosome Organizational Features Govern Early Steps of Meiotic Chiasma Formation

2002 • 350 citations

Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis

2002 • 333 citations

The Yeast Red1 Protein Localizes to the Cores of Meiotic Chromosomes

1997 • 330 citations

Chromosome condensation and sister chromatid pairing in budding yeast.

1994 • 328 citations

Female Germ Cell Aneuploidy and Embryo Death in Mice Lacking the Meiosis-Specific Protein SCP3

2002 • 328 citations

A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction

2001 • 321 citations

Clustering of meiotic double-strand breaks on yeast chromosome III

1997 • 317 citations

Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis

2002 • 307 citations

AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

1998 • 303 citations

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

1993 • 301 citations

Functional Genomics Identifies Monopolin

2000 • 296 citations

Meiotic Synapsis in the Absence of Recombination

1998 • 292 citations

Crossover interference is abolished in the absence of a synaptonemal complex protein

1994 • 285 citations

Pds5p Is an Essential Chromosomal Protein Required for Both Sister Chromatid Cohesion and Condensation in Saccharomyces cerevisiae

2000 • 273 citations

Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.

1994 • 271 citations

Scc1/Rad21/Mcd1 Is Required for Sister Chromatid Cohesion and Kinetochore Function in Vertebrate Cells

2001 • 267 citations

Mitosis: a history of division

2001 • 265 citations

Pds5 cooperates with cohesin in maintaining sister chromatid cohesion

2000 • 264 citations

The Mechanism Of Crossing-over...

2012 • 259 citations

Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I

2001 • 244 citations

Meiotic recombination, noncoding DNA and genomic organization in Caenorhabditis elegans.

1995 • 241 citations

Meiosis in asynaptic yeast.

1990 • 239 citations

The Aurora B Kinase AIR-2 Regulates Kinetochores during Mitosis and Is Required for Separation of Homologous Chromosomes during Meiosis

2002 • 235 citations

Suppression of DNA replication via Mos function during meiotic divisions in Xenopus oocytes.

1994 • 227 citations

Recombination and maternal age-dependent nondisjunction: molecular studies of trisomy 16.

1995 • 224 citations

Requirement of the Spindle Checkpoint for Proper Chromosome Segregation in Budding Yeast Meiosis

2000 • 217 citations

The critical role of the MAP kinase pathway in meiosis II in Xenopus oocytes is mediated by p90Rsk

2000 • 217 citations

Novel Meiosis-Specific Isoform of Mammalian SMC1

2001 • 206 citations

Regulation of Human Separase by Securin Binding and Autocleavage

2002 • 204 citations

Genetic scrambling as a defence against meiotic drive

1991 • 196 citations

Chromosome Segregation in Mitosis and Meiosis

1985 • 193 citations

Domain Organization at the Centromere and Neocentromere

2001 • 188 citations

Origins of the machinery of recombination and sex

2002 • 186 citations

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

1999 • 184 citations

Classification of the caspase–hemoglobinase fold: Detection of new families and implications for the origin of the eukaryotic separins

2002 • 177 citations

Unusual nuclear structures in meiotic prophase of fission yeast: a cytological analysis.

1993 • 177 citations

Inhibitors of DNA topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis.

1991 • 174 citations

Ergebnisse über die Konstitution der chromatischen Substanz des Zellkerns.

1904 • 166 citations

Metaphase to Anaphase (mat) Transition–Defective Mutants inCaenorhabditis elegans

2000 • 161 citations

Nonrandom chromosomal abnormalities in hematologic disorders of man.

1975 • 144 citations

Pre-meiotic S phase is linked to reductional chromosome segregation and recombination

2001 • 141 citations

Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans

2001 • 140 citations

Intermediates of Yeast Meiotic Recombination Contain Heteroduplex DNA

2001 • 136 citations

The Relation between the Axial Complex of Meiotic Prophase Chromosomes and Chromosome Pairing in a Salamander (Plethodon cinereus)

1958 • 130 citations

The APC is dispensable for first meiotic anaphase in Xenopus oocytes

2000 • 128 citations

The chromosome replication cycle

2002 • 124 citations

Organization of SCP1 Protein Molecules within Synaptonemal Complexes of the Rat

1996 • 123 citations

The Cohesion Protein MEI-S332 Localizes to Condensed Meiotic and Mitotic Centromeres until Sister Chromatids Separate

1998 • 123 citations

EMB-30: An APC4 Homologue Required for Metaphase-to-Anaphase Transitions during Meiosis and Mitosis inCaenorhabditis elegans

2000 • 123 citations

Characterization of the components of the putative mammalian sister chromatid cohesion complex

1999 • 118 citations

Activation of the anaphase-promoting complex and degradation of cyclin B is not required for progression from Meiosis I to II in Xenopus oocytes

2001 • 115 citations

Evolutionary conservation between budding yeast and human kinetochores

2001 • 113 citations

Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation

2001 • 109 citations

Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast

2000 • 108 citations

Meiosis-specific formation of joint DNA molecules containing sequences from homologous chromosomes

1994 • 106 citations

Kinetochore structure and its role in chromosome orientation during the first meiotic division in male D. melanogaster

1981 • 105 citations

Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat

1998 • 101 citations

Tension, microtubule rearrangements, and the proper distribution of chromosomes in mitosis

1989 • 99 citations

Spo13 protects meiotic cohesin at centromeres in meiosis I

2002 • 90 citations

STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis

2002 • 83 citations

A yeast acts in (Cis) to inhibit meiotic gene conversion of adjacent sequences

1988 • 73 citations

Hanging on to your homolog: the roles of pairing, synapsis and recombination in the maintenance of homolog adhesion

2000 • 71 citations

The Reduction of Chromosome Number in Meiosis Is Determined by Properties Built into the Chromosomes

2000 • 70 citations

Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I

2002 • 69 citations

Cohesin Defects Lead to Premature Sister Chromatid Separation, Kinetochore Dysfunction, and Spindle-assembly Checkpoint Activation

2002 • 65 citations

Premitotic chromosome individualization in mammalian cells depends on topoisomerase II activity

2000 • 59 citations

Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation

2002 • 56 citations

Progression into and out of mitosis

1999 • 54 citations

Spo13 regulates cohesin cleavage

2002 • 49 citations

Cdc6 synthesis regulates replication competence in Xenopus oocytes

2002 • 42 citations

Verhandlungen des naturforschenden Vereines in Brünn

1881 • 37 citations

The Mechanism of Crossing-Over. IV

1916 • 35 citations

Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes

2002 • 31 citations

Chromosome Segregation and Cancer

1999 • 10 citations