5-Hydroxytryptamine and 5-Hydroxytryptamine-3 Receptor Antagonists

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

TWO KINDS OF TRYPTAMINE RECEPTOR

1957 • 838 citations

SERUM VASOCONSTRICTOR (SEROTONIN)

1948 • 530 citations

Efficacy of Ondansetron (Gr 38032F) and the Role of Serotonin in Cisplatin-Induced Nausea and Vomiting

1990 • 417 citations

Comparison of the 5-Hydroxytryptamine₃(Serotonin) Antagonist Ondansetron (Gr 38032F) with High-Dose Metoclopramide in the Control of Cisplatin-Induced Emesis

1990 • 409 citations

5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterization

1988 • 354 citations

The release of 5‐hydroxytryptamine in relation to pressure exerted on the intestinal mucosa

1959 • 298 citations

5‐Hydroxytryptamine participation in the vagal inhibitory innervation of the stomach

1967 • 203 citations

OBSERVATIONS CONCERNING THE ACTION OF 5‐HYDROXYTRYPTAMINE ON THE PERISTALTIC REFLEX

1958 • 190 citations

Serotonin: Synthesis and Release from the Myenteric Plexus of the Mouse Intestine

1965 • 181 citations

GR 38032F (Ondansetron), a selective 5HT3 receptor antagonist, slows colonic transit in healthy man

1990 • 165 citations

Involvement of 5-Hydroxytryptamine, Prostaglandin E2, and Cyclic Adenosine Monophosphate in Cholera Toxin-Induced Fluid Secretion in the Small Intestine of the Rat In Vivo

1989 • 156 citations

A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonized by ICS 205 930

1988 • 137 citations

Dwarfs

1990 • 125 citations

5-Hydroxytryptamine and cholera secretion: a histochemical and physiological study in cats.

1983 • 122 citations

5-HT2 and 5-HT3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat

1990 • 121 citations

Calcium dependence of serotonin-induced changes in rabbit ileal electrolyte transport.

1980 • 109 citations

Colonic transit in man is slowed by ondansetron (GR38032F), a selective 5‐hydroxytryptamine receptor (type 3) antagonist

1990 • 108 citations

Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine of the rat in vivo

1986 • 102 citations

5-Hydroxytryptamine: New Receptors and Novel Drugs for Gastrointestinal Motor Disorders

1990 • 85 citations

Release of endogenous 5-hydroxytryptamine from resting and stimulated enteric neurons

1981 • 81 citations

Pharmacokinetics and Pharmacodynamics of Atracurium in Infants and Children

1990 • 76 citations

The effect of GR38032F, novel 5‐HT₃‐receptor antagonist on gastric emptying in the guinea‐pig

1987 • 74 citations

The Effects of Vagal Nerve Stimulation on Endoluminal Release of Serotonin and Substance P into the Feline Small Intestine

1985 • 64 citations

Isolation of Enteramine from Extracts of Posterior Salivary Glands of Octopus Vulgaris and of Discoglossus Pictus Skin

1953 • 53 citations

Remission of symptoms in carcinoid syndrome with a new 5-hydroxytryptamine M receptor antagonist.

1987 • 52 citations

Effect of ICS 205-930 (a specific 5-HT3 receptor antagonist) on gastric emptying of a solid meal in normal subjects.

1988 • 51 citations

From metoclopramide to selective gut motility stimulants and 5-HT3 receptor antagonists.

1988 • 51 citations

Gastric Emptying and Subjective Symptoms of Nausea: Lack of Effects of a 5-Hydroxytryptamine-3 Antagonist Ondansetron on Gastric Emptying in Patients with Gastric Stasis Syndrome

1990 • 50 citations

Colonic Secretion Mediated by Prostaglandin E2 and 5-Hydroxytryptamine May Contribute to Diarrhea due to Morphine Withdrawal in the Rat

1984 • 46 citations

Noradrenergic innervation of serotoninergic neurons in the myenteric plexus

1987 • 45 citations

Effect of selective 5HT3 antagonist (GR 38032F) on small intestinal transit and release of gastrointestinal peptides

1989 • 44 citations

Prostaglandin E2 is a mediator of 5-hydroxytryptamine induced water and electrolyte secretion in the human jejunum.

1988 • 39 citations

Intraluminal release of serotonin, substance P, and gastrin in the canine small intestine

1987 • 38 citations

Inhibition of cholera toxin-induced intestinal secretion by the 5-HT3 receptor antagonist ICS 205?930

1989 • 33 citations

Serotonin participation in gut withdrawal from opiates.

1979 • 32 citations

Therapy for Symptoms in the Carcinoid Syndrome

1989 • 26 citations

Regionally selective cholinergic stimulation by BRL 24924 in the human isolated gut.

1988 • 23 citations

A739 ONDANSETRON, A SELECTIVE SEROTONIN TYPE 3 (5-HT3) ANTAGONIST, REDUCES NAUSEA AND VOMITING IN FEMALES FOLLOWING MAJOR GYNECOLOGIC SURGERY

1990 • 11 citations

A double‐blind dose ranging study of BRL 24924 and metoclopramide on lower oesophageal sphincter pressure in healthy volunteers.

1989 • 6 citations

A33 RANDOMIZED, DOUBLE-BLIND COMPARISON OF ONDANSETRON AND PLACEBO IN THE TREATMENT OF POSTOPERATIVE NAUSEA AND VOMITING

1990 • 6 citations