Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: update on defibrotide and other current investigational therapies

Bone marrow transplant

1997 • 3,583 citations

Bone Marrow Transplant

2001 • 3,479 citations

Bone marrow transplant

1989 • 3,423 citations

Hepatogastroenterology

2012 • 1,367 citations

Veno-occlusive Disease of the Liver and Multiorgan Failure after Bone Marrow Transplantation: A Cohort Study of 355 Patients

1993 • 1,173 citations

Regimen-related toxicity in patients undergoing bone marrow transplantation.

1988 • 876 citations

Toxic Injury to Hepatic Sinusoids: Sinusoidal Obstruction Syndrome (Veno-Occlusive Disease)

2002 • 661 citations

The syndrome of hepatic veno-occlusive disease after marrow transplantation

1995 • 475 citations

Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation

2003 • 367 citations

Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party.

1998 • 344 citations

A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group

1994 • 341 citations

Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast Cancer

1993 • 318 citations

Multi-institutional use of defibrotide in 88 patients after stem cell transplantation with severe veno-occlusive disease and multisystem organ failure: response without significant toxicity in a high-risk population and factors predictive of outcome

2002 • 309 citations

Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation

2003 • 304 citations

Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera

2000 • 267 citations

Venoocclusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation.

1993 • 257 citations

Treatment of Severe Veno-Occlusive Disease With Defibrotide: Compassionate Use Results in Response Without Significant Toxicity in a High-Risk Population

1998 • 255 citations

Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation

2002 • 239 citations

Defibrotide in the treatment of children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention

2003 • 205 citations

Hepatic Veno-occlusive Disease (Sinusoidal Obstruction Syndrome) After Hematopoietic Stem Cell Transplantation

2003 • 198 citations

Cellular Target of Cyclophosphamide Toxicity in the Murine Liver: Role of Glutathione and Site of Metabolic Activation

1996 • 195 citations

Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: a prospective, randomized trial [see comments]

1992 • 190 citations

Treatment of Hepatic Venocclusive Disease With Recombinant Human Tissue Plasminogen Activator and Heparin in 42 Marrow Transplant Patients

1997 • 189 citations

Defibrotide for the treatment of hepatic veno‐occlusive disease: results of the European compassionate‐use study

2000 • 184 citations

Ursodiol Prophylaxis against Hepatic Complications of Allogeneic Bone Marrow Transplantation

1998 • 184 citations

A prospective survey on incidence, risk factors and therapy of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation.

2005 • 168 citations

Gemtuzumab ozogamicin-associated sinusoidal obstructive syndrome (SOS): An overview from the research on adverse drug events and reports (RADAR) project

2006 • 168 citations

Sirolimus and Thrombotic Microangiopathy after Allogeneic Hematopoietic Stem Cell Transplantation

2005 • 165 citations

Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: a prospective, randomized trial [see comments]

1992 • 163 citations

Hepatic injury after nonmyeloablative conditioning followed by allogeneic hematopoietic cell transplantation: a study of 193 patients

2003 • 157 citations

Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation

2003 • 153 citations

Safety and efficacy of gemtuzumab ozogamicin in pediatric patients with advanced CD33+ acute myeloid leukemia

2005 • 153 citations

The effect of busulphan on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite: time interval influence on therapeutic efficacy and therapy-related toxicity

2000 • 147 citations

The Japanese multicenter open randomized trial of ursodeoxycholic acid prophylaxis for hepatic veno-occlusive disease after stem cell transplantation

2000 • 146 citations

Plasminogen Activator Inhibitor-1 Confirms the Diagnosis of Hepatic Veno-Occlusive Disease in Patients With Hyperbilirubinemia After Bone Marrow Transplantation

1997 • 143 citations

Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide

2002 • 135 citations

Defibrotide for the treatment of hepatic veno-occlusive disease: results of the European compassionate-use study

2000 • 127 citations

Prevention of veno-occlusive disease with defibrotide after allogeneic stem cell transplantation

2004 • 127 citations

Veno-occlusive disease of the liver after busulfan, melphalan, and thiotepa conditioning therapy: Incidence, risk factors, and outcome

1999 • 126 citations

Hemostatic complications in bone marrow transplantation: a retrospective analysis of 447 patients

2002 • 117 citations

Endothelial dysfunction after bone marrow transplantation: Increase of soluble thrombomodulin and PAI-1 in patients with multiple transplant-related complications

1998 • 107 citations

Stem cell transplantation in children with infantile osteopetrosis is associated with a high incidence of VOD, which could be prevented with defibrotide

2006 • 103 citations

Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome

2003 • 101 citations

LOW MOLECULAR WEIGHT HEPARIN FOR THE PREVENTION OF VENO-OCCLUSIVE DISEASE OF THE LIVER IN BONE MARROW TRANSPLANTATION PATIENTS1

1996 • 99 citations

Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome

2003 • 94 citations

A randomized trial of heparin plus ursodiol vs heparin alone to prevent hepatic veno-occlusive disease after hematopoietic stem cell transplantation

2002 • 91 citations

A phase I/II study of prostaglandin E₁ for the prevention of hepatic venocclusive disease after bone marrow transplantation

1993 • 88 citations

Prophylactic heparin does not prevent liver veno‐occlusive disease following autologous bone marrow transplantation

1991 • 87 citations

Risk factors for hepatic veno-occlusive disease following HLA-identical sibling bone marrow transplants for leukemia.

1996 • 86 citations

Decreased incidence of hepatic veno-occlusive disease and fewer hemostatic derangements associated with intravenous busulfan vs oral busulfan in adults conditioned with busulfan + cyclophosphamide for allogeneic bone marrow transplantation

2004 • 86 citations

Cyclophosphamide following Targeted Oral Busulfan as Conditioning for Hematopoietic Cell Transplantation: Pharmacokinetics, Liver Toxicity, and Mortality

2007 • 86 citations

Abnormal Expression and Subcellular Distribution of Subunit Proteins of the AP-3 Adaptor Complex Lead to Platelet Storage Pool Deficiency in the Pearl Mouse

1999 • 84 citations

Hepatic veno-occlusive disease in pediatric stem cell transplantation: impact of pre-emptive antithrombin III replacement and combined antithrombin III/defibrotide therapy.

2006 • 83 citations

Defibrotide, a single-stranded polydeoxyribonucleotide acting as an adenosine receptor agonist

1993 • 83 citations

Retrospective multivariate analysis of hepatic veno-occlusive disease after blood or marrow transplantation: possible beneficial use of low molecular weight heparin

2001 • 83 citations

Regimen-related toxicity of a busulfan-cyclophosphamide conditioning regimen in 70 patients undergoing allogeneic bone marrow transplantation.

1991 • 81 citations

Prophylactic defibrotide in allogeneic stem cell transplantation: minimal morbidity and zero mortality from veno-occlusive disease

2007 • 80 citations

PGE1 accelerates thrombolysis by tissue plasminogen activator

1989 • 73 citations

High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy

2006 • 72 citations

Busulfan levels are influenced by prior treatment and are associated with hepatic veno-occlusive disease and early mortality but not with delayed complications following marrow transplantation

2001 • 70 citations

Acute effects of defibrotide, an experimental antithrombotic agent, on fibrinolysis and blood prostanoids in man

1988 • 67 citations

Plasminogen activator inhibitor‐1 is an independent diagnostic marker as well as severity predictor of hepatic veno‐occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide

2002 • 65 citations

A pilot study of continuous infusion heparin for the prevention of hepatic veno-occlusive disease after bone marrow transplantation.

1990 • 62 citations

Defibrotide Stimulates Expression of Thrombomodulin in Human Endothelial Cells

1994 • 62 citations

Isolation and Identification of Aptamers from Defibrotide That Act as Thrombin Antagonists in Vitro

1994 • 60 citations

Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis

2005 • 59 citations

Veno-occlusive disease of the liver complicating ABMT successfully treated with recombinant tissue plasminogen activator (rt-PA).

1990 • 58 citations

Antithrombin-III for the treatment of chemotherapy-induced organ dysfunction following bone marrow transplantation

1997 • 58 citations

Low molecular weight heparin for the prevention of hepatic veno-occlusive disease (VOD) after hematopoietic stem cell transplantation: a prospective phase II study

2003 • 57 citations

Defibrotide for the treatment of hepatic veno‐occlusive disease in children

2006 • 57 citations

HEPATIC DYSFUNCTION FOLLOWING T-CELL-DEPLETED ALLOGENEIC BONE MARROW TRANSPLANTATION

1991 • 54 citations

Pilot trial of prophylactic ursodiol to decrease the incidence of veno-occlusive disease of the liver in allogeneic bone marrow transplant patients.

1992 • 54 citations

Parameters of the fibrinolytic system in patients undergoing BMT: elevation of PAI-1 in veno-occlusive disease.

1994 • 53 citations

Transjugular intrahepatic portosystemic shunting (TIPS) for treatment of severe hepatic veno-occlusive disease.

1996 • 52 citations

Defibrotide, by enhancing prostacyclin generation, prevents endothelin-1 induced contraction in human saphenous veins

1990 • 48 citations

Allogeneic liver transplantation for hepatic veno-occlusive disease after bone marrow transplantation--clinical and immunological considerations.

1995 • 47 citations

Association of pulmonary function testing abnormalities and severe veno-occlusive disease of the liver after marrow transplantation

1998 • 39 citations

Recombinant human tissue plasminogen activator for the treatment of severe hepatic veno-occlusive disease in pediatric bone marrow transplant patients.

1996 • 38 citations

Recombinant tissue plasminogen activator (rtPA) for the treatment of hepatic veno-occlusive disease (VOD)

1999 • 38 citations

Marked reduction in the incidence of hepatic veno-occlusive disease after allogeneic hematopoietic stem cell transplantation with CD34+ positive selection

2001 • 37 citations

Transforming growth factor beta-1 released from platelets contributes to hypercoagulability in veno-occlusive disease following hematopoetic stem cell transplantation

2005 • 36 citations

Antithrombotic effect and clinical potential of defibrotide.

1993 • 34 citations

Tissue plasminogen activator (tPA) as therapy for hepatotoxicity following bone marrow transplantation

1999 • 32 citations

Positive selection for CD34+ reduces the incidence and severity of veno-occlusive disease of the liver after HLA-identical sibling allogeneic peripheral blood stem cell transplantation

2003 • 31 citations

Recombinant tissue plasminogen activator (rt‐PA) for veno‐occlusive liver disease in pediatric autologous bone marrow transplant patients

1994 • 28 citations

Prevention and Treatment of Hepatic Venocclusive Disease after High-Dose Cytoreductive Therapy

1998 • 28 citations

Antithrombin treatment of severe hepatic veno-occlusive disease in children with cancer

1999 • 24 citations

Effect of sodium nitroprusside on ischemia-reperfusion injuries of the rat liver.

2004 • 24 citations

Hepatic veno-occlusive disease in pediatric stem cell recipients: successful treatment with continuous infusion of prostaglandin E 1 and low-dose heparin

1998 • 23 citations

Anti-Thrombin III in the Management of Hematopoietic Stem-Cell Transplantation—Associated Toxicity

2004 • 17 citations

Charcoal hemofiltration for hepatic veno-occlusive disease after hematopoietic stem cell transplantation

2001 • 17 citations

Treatment of hepatic veno-occlusive disease with low-dose tissue plasminogen activator: impact on coagulation profile.

1996 • 16 citations

Absence of veno‐occlussive disease in a cohort of multiple myeloma patients undergoing autologous stem cell transplantation with targeted busulfan dosage

2006 • 15 citations

Veno-occlusive disease (VOD) of the liver in Korean patients following allogeneic bone marrow transplantation (BMT): efficacy of recombinant human tissue plasminogen activator (rt-PA) treatment

1996 • 14 citations

No beneficial effects, but severe side effects caused by recombinant human tissue plasminogen activator for treatment of hepatic veno-occlusive disease after allogeneic bone marrow transplantation.

1995 • 12 citations

Successful treatment of an infant with veno-occlusive disease developed after allogeneic bone marrow transplantation by tissue plasminogen activator, heparin and prostaglandin E1

1995 • 12 citations

The action of polyanionic agents defibrotide and pentosan sulphate on fibrinolytic activity in the laboratory rat

1996 • 11 citations

[Percutaneous intrahepatic portosystemic shunting in the treatment of veno-occlusive disease of the liver after bone marrow transplantation].

2000 • 11 citations

Defibrotide (DF) for the Treatment of Severe Veno-Occlusive Disease (sVOD) and Multi-Organ Failure (MOF) Post SCT: Final Results of a Multi-Center, Randomized, Dose-Finding Trial.

2006 • 10 citations

Effects of Defibrotide in Acute Renal Failure due to Thrombotic Microangiopathy

1986 • 8 citations

Recombinant tissue plasminogen activator (rTPA) for hepatic veno-occlusive disease after allogeneic BMT in a pediatric patient.

1995 • 6 citations

O-Linked Glycosylation with Sialylated T-Antigen: A Novel Carbohydrate Determinant of von Willebrand Factor Antigen Levels.

2006 • 4 citations

Deleted Work

1955 • 0 citations