Functional and ultrastructural features of ethanol/bile salts interaction in the isolated perfused rat liver

A Multicenter, Controlled Trial of Ursodiol for the Treatment of Primary Biliary Cirrhosis

1991 • 727 citations

Enzymic Analysis of Steroid Hormones

1960 • 679 citations

Mechanisms and regulation of bile secretion

1991 • 402 citations

The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities.

1982 • 375 citations

Pathogenesis of alcohol-induced accumulation of protein in the liver.

1977 • 308 citations

The increase in bilayer fluidity of rat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes.

1980 • 272 citations

Bile acid-induced liver toxicity: Relation to the hydrophobic-hydrophilic balance of bile acids

1986 • 271 citations

Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.

1993 • 251 citations

Molecular aspects of membrane stabilization by ursodeoxycholate

1993 • 212 citations

Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria

1994 • 211 citations

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts:In vitro studies in rat hepatocytes and human erythrocytes

1991 • 208 citations

Hepatic injury induced by bile salts: Correlation between biochemical and morphological events

1990 • 207 citations

Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up

1985 • 174 citations

Effects of ethanol on liver microtubules and Golgi apparatus. Possible role in altered hepatic secretion of plasma proteins.

1979 • 164 citations

Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasis.

1993 • 164 citations

Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport.

1988 • 130 citations

Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.

1993 • 124 citations

Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytes

1993 • 121 citations

Cell volume and bile acid excretion

1992 • 111 citations

Cholesterol gallstone dissolution in bile. Dissolution kinetics of crystalline cholesterol monohydrate by conjugated chenodeoxycholate-lecithin and conjugated ursodeoxycholate-lecithin mixtures: dissimilar phase equilibria and dissolution mechanisms

1983 • 111 citations

Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species

1986 • 110 citations

Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates.

1989 • 107 citations

Tauroursodeoxycholate prevents biliary protein excretion induced by other bile salts in the rat

1985 • 103 citations

Bile acid metabolism in mammals. Ultrastructural studies on the intrahepatic cholestasis induced by lithocholic and chenodeoxycholic acids in the rat.

1971 • 102 citations

Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes.

1994 • 99 citations

Ethanol Ingestion — Commonest Cause of Elevated Plasma Osmolality?

1971 • 87 citations

Effect of chenodeoxycholic and ursodeoxycholic acids on isolated adult human hepatocytes

1984 • 81 citations

Choleretic and cholestatic effects of infused bile salts in the rat

1979 • 56 citations

Ursodeoxycholate mobilizes intracellular Ca2+ and activates phosphorylase a in isolated hepatocytes

1993 • 54 citations

URSODEOXYCHOLIC ACID IN THE TREATMENT OF ALCOHOLIC LIVER-DISEASE

1991 • 45 citations

The acute and chronic effects of ethanol administration on bile secretion in the rat.

1973 • 44 citations

The effect of changes in the fluid state of rat liver plasma membrane on the transport of taurocholate

1987 • 41 citations

Determination of the biliary dead space usign14C-taurocholate as a marker

1973 • 36 citations

Protective effect of tauroursodeoxycholate against chenodeoxycholate-induced damage to cultured rabbit gastric cells

1991 • 34 citations

Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL

1993 • 31 citations

Recent advances in bile acid research

1985 • 26 citations

Effect of Ethanol and Chlorpromazine on Transhepatic Transport and Biliary Secretion of Horseradish Peroxidase

1984 • 25 citations

Influence of tauroursodeoxycholic and taurodeoxycholic acids on hepatic metabolism and biliary secretion of phosphatidylcholine in the isolated rat liver

1986 • 25 citations

Effect of hypertonic stress on liver cell volume, bile flow, and volume-regulatory K+ fluxes

1989 • 24 citations

Recent advances in bile acid research

1986 • 21 citations

Microtubule-independent choleresis and anti-cholestatic action of tauroursodeoxycholate in colchicine-treated rat liver

1992 • 21 citations

Effect of tauroursodeoxycholic acid on serum liver enzymes and dyspeptic symptoms in patients with chronic active hepatitis

1993 • 20 citations

Treatment of chronic active hepatitis and primary biliary cirrhosis with ursodeoxycholic acid.

1992 • 16 citations

Study of biologically relevant physical-chemical properties of bile salts by reverse-phase liquid chromatography

1987 • 12 citations

Reply

1993 • 8 citations

ETHANOL IMPAIRS BILIARY LYSOSOMAL ENZYME RELEASE IN RATS

1986 • 7 citations

Loss of enzymes of detoxification during rat lipocyte activation in culture and in vivo ? A mechanism for increased susceptibility to oxidant stress during hepatic injury

1993 • 7 citations