Use of Probe Drugs as Predictors of Drug Metabolism in Humans

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

1994 • 749 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

1992 • 536 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

Geographical/Interracial Differences in Polymorphic Drug Oxidation

1995 • 431 citations

Noninvasive tests of CYP3A enzymes

1994 • 414 citations

Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients.

1994 • 350 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test

1994 • 291 citations

The use of caffeine for enzyme assays: A critical appraisal

1993 • 282 citations

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences.

1987 • 281 citations

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

1996 • 280 citations

Rifampin drastically reduces plasma concentrations and effects of oral midazolam

1996 • 238 citations

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

1988 • 199 citations

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine

1990 • 196 citations

Interphenotype differences in disposition and effect on gastrin levels of omeprazole—suitability of omeprazole as a probe for CYP2C19.

1995 • 187 citations

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva

1994 • 179 citations

Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*

1996 • 172 citations

Advances in Drug Metabolism in Man

1995 • 167 citations

“It's the genes, stupid” Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

1995 • 162 citations

Polymorphic oxidation of sparteine and debrisoquine: Related pharmacogenetic entities

1982 • 160 citations

Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms*

1995 • 154 citations

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

1992 • 149 citations

Extremely Rapid Hydroxylation of Debrisoquine

1985 • 144 citations

Assessment of Liver Metabolic Function

1994 • 138 citations

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

1993 • 137 citations

The erythromycin breath test predicts the clearance of midazolam*

1995 • 132 citations

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

1992 • 132 citations

Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations

1996 • 128 citations

Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

1992 • 120 citations

Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1

1995 • 111 citations

Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: Coincidence with plasma clearance and breath test

1994 • 107 citations

Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo*

1995 • 101 citations

The erythromycin breath test as a predictor of cyclosporine blood levels

1990 • 99 citations

Frequency distribution of dapsone N-hydroxylase, a putative probe for P4503A4 activity, in a white population

1994 • 90 citations

Rapid detection of CYP2D6 null alleles by long distance-and multiplex-polymerase chain reaction

1996 • 86 citations

Drug Interactions and the Cytochrome P450 System

1995 • 86 citations

Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.

1992 • 80 citations

Caffeine as a probe for CYP1A2 activity

1994 • 74 citations

Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation.

1995 • 71 citations

The contribution of N-hydroxylation and acetylation to dapsone pharmacokinetics in normal subjects

1990 • 64 citations

Erythromycin breath test predicts oral clearance of cyclosporine in kidney transplant recipients

1992 • 58 citations

Metabolism of cytochrome P4503A substrates in vivo administered by the same route: Lack of correlation between alfentanil clearance and erythromycin breath test

1994 • 57 citations

P450 3A activity and cyclosporine dosing in kidney and heart transplant recipients

1994 • 54 citations

Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity.

1995 • 37 citations

Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine*

1996 • 35 citations

Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: Comparison of sparteine and dextromethorphan*

1996 • 25 citations