Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

Clinical pharmacokinetics; concepts and applications

1989 • 2,266 citations

The effect of age upon liver volume and apparent liver blood flow in healthy man

1989 • 616 citations

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

1992 • 536 citations

Biochemistry and molecular biology of the human CYP2C subfamily

1994 • 534 citations

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues.

1990 • 487 citations

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man.

1987 • 475 citations

Extrahepatic Metabolism of Drugs in Humans

1994 • 426 citations

First-pass metabolism of cyclosporin by the gut

1991 • 425 citations

CYP3A gene expression in human gut epithelium

1994 • 367 citations

A potentially hazardous interaction between erythromycin and midazolam

1993 • 352 citations

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice*

1995 • 349 citations

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1992 • 337 citations

Tuberculosis in the United States

1989 • 308 citations

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel: Lack of prediction by the erythromycin breath test

1994 • 291 citations

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

1995 • 275 citations

Physiological disposition of verapamil in man

1976 • 244 citations

Identification of P450 enzymes involved in metabolism of verapamil in humans

1993 • 200 citations

Update on Rifampin Drug Interactions

1987 • 198 citations

Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes.

1992 • 197 citations

The effect of dextro-, levo-, and racemic verapamil on atrioventricular conduction in humans

1985 • 137 citations

Pharmacokinetics of oral and intravenous rifampicin during chronic administration

1985 • 136 citations

Pharmacokinetics, bioavailability and ECG response of verapamil in patients with liver cirrhosis.

1981 • 118 citations

Effects of d,l-verapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolism

1985 • 118 citations

Urinary excretion of 6?-hydroxycortisol and the time course measurement of enzyme induction in man

1989 • 113 citations

Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract

1992 • 110 citations

Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

1995 • 106 citations

Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil

1981 • 105 citations

Changes in antipyrine and indocyanine green kinetics during nifedipine, verapamil, and diltiazem therapy

1986 • 94 citations

Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects.

1992 • 90 citations

Nonchiral, homochiral and composite chiral drugs

1993 • 82 citations

Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action.

1990 • 72 citations

Stereoselective protein binding of verapamil enantiomers

1988 • 72 citations

The value of Doppler US in the study of hepatic hemodynamics

1990 • 71 citations

Hepatic blood flow and drug metabolism in patients on enzyme-inducing anticonvulsants

1982 • 69 citations

Superiority of stable isotope techniques in the assessment of the bioavailability of drugs undergoing extensive first pass elimination

1981 • 69 citations

An enantiomer-enantiomer interaction of (S)- and (R)-propafenone modifies the effect of racemic drug therapy.

1994 • 51 citations

Verapamil pharmacokinetics and apparent hepatic and renal blood flow.

1985 • 48 citations

Near-total Reduction in Verapamil Bioavailability by Rifampin

1988 • 47 citations

Age‐dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin.

1991 • 35 citations

Simultaneous Assessment of the Intravenous and Oral Disposition of the Enantiomers of Racemic Nimodipine by Chiral Stationary- Phase High-Performance Liquid Chromatography and Gas Chromatography/Mass Spectroscopy Combined with a Stable Isotope Technique

1993 • 33 citations

Influence of meso‐caval shunt surgery on verapamil kinetics, bioavailability and response.

1980 • 31 citations

Direct determination of hepatic extraction of verapamil in cardiac patients

1981 • 30 citations

The effects of oral nifedipine on hepatic blood flow in humans

1991 • 26 citations

Verapamil-Rifampin Interaction

1985 • 20 citations

First-pass metabolism.

1983 • 20 citations

Liver blood flow and enzyme induction in man.

1985 • 8 citations