Nanotechnology in bio/clinical analysis

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

"Dip-Pen" Nanolithography

1999 • 2,993 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Analytical Properties of the Nanoelectrospray Ion Source

1996 • 1,816 citations

Culturing nerve cells

1998 • 1,304 citations

Chemical Amplification: Continuous-Flow PCR on a Chip

1998 • 1,174 citations

Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last?

1994 • 950 citations

From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Arnino Acid Analysis

1996 • 837 citations

Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two–colour fluorescence analysis

1996 • 526 citations

Minisequencing: A Specific Tool for DNA Analysis and Diagnostics on Oligonucleotide Arrays

1997 • 348 citations

Beyond micromachining: the potential of diatoms

1999 • 221 citations

A Microscale Electrospray Interface for Online, Capillary Liquid Chromatography/Tandem Mass Spectrometry of Complex Peptide Mixtures

1995 • 202 citations

Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry

1998 • 168 citations

Polypyrrole DNA Chip on a Silicon Device: Example of Hepatitis C Virus Genotyping

1998 • 163 citations

Nucleic acid adducts of chemical carcinogens and mutagens

1983 • 163 citations

Ion spray mass spectrometric detection for liquid chromatography: A concentration- or a mass-flow-sensitive device?

1993 • 148 citations

Real-time detection of DNA hybridization and melting on oligonucleotide arrays by using optical wave guides.

1995 • 121 citations

The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization

1993 • 116 citations

On-Line Coupling of Capillary Electrochromatography, Capillary Electrophoresis, and Capillary HPLC with Nuclear Magnetic Resonance Spectroscopy

1998 • 110 citations

Detection of point mutations in DNA using capillary electrophoresis in a polymer network

1993 • 104 citations

Evolutionary sequence comparisons using high-density oligonucleotide arrays

1998 • 101 citations

Attomole detection of proteins by matrix‐assisted laser desorption/ionization mass spectrometry with the use of picolitre vials

1994 • 101 citations

³²P-Postlabeung Methods for DNA Adduct Detection: Overview and Critical Evaluation

1994 • 98 citations

Patch-Clamp Detection of Neurotransmitters in Capillary Electrophoresis

1996 • 90 citations

Development of a Nanoscale Liquid Chromatography/Electrospray Mass Spectrometry Methodology for the Detection and Identification of DNA Adducts

1997 • 88 citations

Analysis of DNA Adducts in DNA Hydrolysates by Capillary Zone Electrophoresis and Capillary Zone Electrophoresis−Electrospray Mass Spectrometry

1996 • 88 citations

Detection and Identification of Benzo[a]pyrene Diol Epoxide Adducts to DNA Utilizing Capillary Electrophoresis-Electrospray Mass Spectrometry

1996 • 81 citations

Determination of in Vitro Formed DNA Adducts of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Using Capillary Liquid Chromatography/Electrospray Ionization/Tandem Mass Spectrometry

1995 • 77 citations

RNA chip: quality assessment of RNA by microchannel linear gel electrophoresis in injection-molded plastic chips.

1998 • 67 citations

Electroconducting polymers for the construction of DNA or peptide arrays on silicon chips

1998 • 66 citations

Single Cells as Biosensors for Chemical Separations

1995 • 65 citations

Dissection of multi-protein complexes using mass spectrometry: Subunit interactions in transthyretin and retinol-binding protein complexes

1998 • 59 citations

Mass spectrometry for the analysis of carcinogen‐DNA adducts

1992 • 58 citations

On-Line Coupling of Separation Techniques to NMR

1999 • 55 citations

Direct On-Line Coupling of Capillary HPLC with ¹H NMR Spectroscopy for the Structural Determination of Retinyl Acetate Dimers: 2D NMR Spectroscopy in the Nanoliter Scale

1997 • 53 citations

A new mass spectrometric approach to detect modifications in DNA

1994 • 42 citations

Quantitative Analysis of the DNA AdductN2,3-Ethenoguanine Using Liquid Chromatography/Electrospray Ionization Mass Spectrometry

1996 • 41 citations

Planar chip technology for capillary electrophoresis

1994 • 35 citations

On-line nanoscale liquid chromatography nano-electrospray mass spectrometry: effect of the mobile phase composition and the electrospray tip design on the performance of a nanoflowTM electrospray probe

1998 • 35 citations

Capillary Electrophoretic Separation and Laser-Induced Fluorescence Detection of the Major DNA Adducts of Cisplatin and Carboplatin

1995 • 32 citations

General method for determining ethylene oxide and related N7-guanine DNA adducts by gas chromatography-electron capture mass spectrometry

1995 • 29 citations

Analysis of the DNA Damage Induced by Phenyl Glycidyl Ether Using Capillary Zone Electrophoresis–Electrospray Mass Spectrometry

1998 • 24 citations

Patch Clamp Detection in Capillary Electrophoresis

1997 • 21 citations

A strategy for the identification of 2′-deoxynucleoside and 2′--deoxynucleotide adducts using electrospray tandem mass spectrometry

1996 • 19 citations

Will "DNA Chip" Speed Genome Initiative?

1991 • 18 citations

Screening of Receptor Antagonists Using Agonist-Activated Patch Clamp Detection in Chemical Separations

1998 • 12 citations

Genomic, Nanotech Centers Open $200 Million Push by Harvard

1999 • 3 citations

PCR on a Roller Coaster

1998 • 1 citations