Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor

Qinghaosu (Artemisinin): an Antimalarial Drug from China

1985 • 2,138 citations

Antimalarial drug resistance

2004 • 1,072 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 • 805 citations

Cytochrome P-450

1986 • 734 citations

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

1991 • 675 citations

The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module

1999 • 645 citations

Sex is a major determinant of CYP3A4 expression in human liver

2003 • 471 citations

Induction of Drug Metabolism: The Role of Nuclear Receptors

2003 • 449 citations

Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir

1997 • 327 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 260 citations

Identification of human cytochrome P 450 s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

2003 • 226 citations

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

2001 • 220 citations

Sex is a major determinant of CYP3A4 expression in human liver

2003 • 213 citations

A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression

2003 • 208 citations

Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin

1999 • 204 citations

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.

2000 • 200 citations

Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR

2001 • 188 citations

Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine

2002 • 185 citations

Drug-activated nuclear receptors CAR and PXR

2003 • 177 citations

Alternatives to animal experimentation in basic research

2004 • 154 citations

Drug Interactions Between Antiretroviral Drugs and Comedicated Agents

2003 • 150 citations

Antimalarial drug resistance

2004 • 141 citations

Pharmacokinetic Interactions of Antimalarial Agents

2001 • 138 citations

Artemisinin Pharmacokinetics is Time-Dependent during Repeated Oral Administration in Healthy Male Adults

1998 • 125 citations

Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9

2003 • 115 citations

Dynamic Stabilization of Nuclear Receptor Ligand Binding Domains by Hormone or Corepressor Binding

2000 • 108 citations

Artemisinin induces omeprazole metabolism in human beings*

1998 • 92 citations

Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor.

2004 • 85 citations

Transport of Artemisinin and Sodium Artesunate in Caco-2 Intestinal Epithelial Cells

1996 • 80 citations

Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT

2000 • 78 citations

High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement

1999 • 64 citations

Ritonavir Decreases the Nonrenal Clearance of Digoxin in Healthy Volunteers with Known MDR1 Genotypes

2004 • 59 citations

EVIDENCE FOR THE VALIDITY OF CORTISOL 6β-HYDROXYLATION CLEARANCE AS A NEW INDEX FOR IN VIVO CYTOCHROME P450 3A PHENOTYPING IN HUMANS

2003 • 55 citations

Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects

1997 • 48 citations

Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19

1999 • 32 citations

In vitro evidence for auto-induction of artemisinin metabolism in the rat

2001 • 19 citations

Quantitative in vivo and in vitro sex differences in artemisinin metabolism in rat

1999 • 18 citations

Radiolabeled antimalarials: Synthesis of 14C-artemisinin

1996 • 12 citations

Induction, expression and maintenance of cytochrome P450 isoforms in long-term cultures of primary human hepatocytes.

2004 • 9 citations