The transport mechanism of metallothionein is different from that of classical NLS-bearing protein

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

METALLOTHIONEIN

1986 • 1,606 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

A Novel Receptor-Mediated Nuclear Protein Import Pathway

1996 • 669 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.

1995 • 385 citations

A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

1997 • 335 citations

Purification of a Ran-interacting protein that is required for protein import into the nucleus.

1994 • 318 citations

Facilitated nuclear transport of histone H1 and other small nucleophilic proteins

1990 • 278 citations

The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors

1992 • 278 citations

Metallothionein protects DNA from oxidative damage

1993 • 254 citations

Nutritional and Physiological Significance of Metallothionein

1987 • 204 citations

Zinc transfer from transcription factor IIIA fingers to thionein clusters.

1991 • 204 citations

Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development

1983 • 183 citations

Yrb4p, a yeast Ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus

1997 • 163 citations

Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development

1987 • 148 citations

A Karyophilic Protein Forms a Stable Complex with Cytoplasmic Components Prior to Nuclear Pore Binding

1995 • 144 citations

[11] Nuclear protein import using digitonin-permeabilized cells

1992 • 138 citations

Localization of metallothionein in nuclei of growing primary cultured adult rat hepatocytes

1991 • 122 citations

Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4

1996 • 112 citations

The Nuclear Localization Signal of Lymphoid Enhancer Factor-1 Is Recognized by Two Differentially Expressed Srp1-Nuclear Localization Sequence Receptor Proteins

1996 • 97 citations

Metallothionein synthesis and localization in relation to metal storage in rat liver during gestation

1985 • 70 citations

Transient Peaks in Zinc and Metallothionein Levels during Differentiation of 3T3L1 Cells

1999 • 62 citations

Regulation of the ontogeny of rat liver metallothionein mRNA by zinc

1987 • 54 citations

Nuclear Import of Metallothionein Requires Its mRNA to Be Associated with the Perinuclear Cytoskeleton

1999 • 53 citations

Metallothionein and Apoptosis during Differentiation of Myoblasts to Myotubes: Protection against Free Radical Toxicity

1999 • 50 citations

Nucleophilic Distribution of Metallothionein in Human Tumor Cells

1996 • 41 citations

Delay of M-phase onset by aphidicolin can retain the nuclear localization of zinc and metallothionein in 3T3-L1 fibroblasts

2000 • 38 citations

Signal transduction pathways, and nuclear translocation of zinc and metallothionein during differentiation of myoblasts

2000 • 38 citations

Energy-dependent nuclear binding dictates metallothionein localization

2000 • 24 citations

Biosynthesis and Metabolism of Metallothionein in Rat during Perinatal Development

1987 • 15 citations