Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia

The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia

1987 • 19,723 citations

The Structured Clinical Interview for DSM-III-R (SCID)

1992 • 4,294 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

Mapping the Onset of Psychosis: The Comprehensive Assessment of At-Risk Mental States

2005 • 1,860 citations

The primate basal ganglia: parallel and integrative networks

2003 • 1,439 citations

Prediction of Psychosis in Youth at High Clinical Risk

2008 • 1,235 citations

Three‐dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe

2003 • 1,156 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Randomized Controlled Trial of Interventions Designed to Reduce the Risk of Progression to First-Episode Psychosis in a Clinical Sample With Subthreshold Symptoms

2002 • 1,045 citations

Diagnosing Schizophrenia in the Initial Prodromal Phase

2001 • 1,022 citations

Increased baseline occupancy of D ₂ receptors by dopamine in schizophrenia

2000 • 996 citations

Prospective Diagnosis of the Initial Prodrome for Schizophrenia Based on the Structured Interview for Prodromal Syndromes: Preliminary Evidence of Interrater Reliability and Predictive Validity

2002 • 853 citations

Size of burden of schizophrenia and psychotic disorders

2005 • 696 citations

Basal Ganglia Output and Cognition: Evidence from Anatomical, Behavioral, and Clinical Studies

2000 • 650 citations

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

2002 • 640 citations

Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum

2003 • 552 citations

Randomized, Double-Blind Trial of Olanzapine Versus Placebo in Patients Prodromally Symptomatic for Psychosis

2006 • 530 citations

From dopamine to salience to psychosis—linking biology, pharmacology and phenomenology of psychosis

2005 • 494 citations

A systematic review and quantitative appraisal of fMRI studies of verbal fluency: Role of the left inferior frontal gyrus

2006 • 469 citations

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1980 • 459 citations

Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

1999 • 452 citations

Declining Transition Rate in Ultra High Risk (Prodromal) Services: Dilution or Reduction of Risk?

2007 • 411 citations

Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States

2005 • 387 citations

Elevated dopa decarboxylase activity in living brain of patients with psychosis.

1994 • 335 citations

Human positron emission tomographic [¹⁸F]Fluorodopa studies correlate with dopamine cell counts and levels

1993 • 331 citations

Presynaptic dopamine function in striatum of neuroleptic-naive schizophrenic patients

1995 • 323 citations

Pathophysiologically based treatment interventions in schizophrenia

2006 • 319 citations

Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(β-11C) DOPA and PET

1999 • 286 citations

Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia

1999 • 243 citations

Presynaptic Dopaminergic Dysfunction in Schizophrenia

2004 • 227 citations

Decreased Presynaptic Dopamine Function in the Left Caudate of Depressed Patients With Affective Flattening and Psychomotor Retardation

2001 • 182 citations

Presynaptic dopaminergic function in the striatum of schizophrenic patients

1997 • 163 citations

Randomized, Double-Blind Trial of Olanzapine Versus Placebo in Patients Prodromally Symptomatic for Psychosis

2006 • 158 citations

Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis

2007 • 141 citations

Correction of head movement on PET studies: comparison of methods.

2006 • 135 citations

Striatal Dopamine Synthesis in First-degree Relatives of Patients with Schizophrenia

2007 • 123 citations

PET Study of [¹⁸F]6-Fluoro-<scp>l</scp>-Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium

2002 • 122 citations

Effects of Psychotic State and Task Demand on Prefrontal Function in Schizophrenia: An fMRI Study of Overt Verbal Fluency

2005 • 108 citations

Imaging Human Mesolimbic Dopamine Transmission With Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum

2003 • 107 citations

6-18F-DOPA PET study in patients with schizophrenia

2000 • 101 citations

Correction of head movement in PET studies: a comparison of methods

2004 • 99 citations

The Metabolism of [¹⁸F]6‐Fluoro‐l‐3,4‐Dihydroxyphenylalanine in the Hooded Rat

1987 • 98 citations

Regulation of striatal aromatic L-amino acid decarboxylase: Effects of blockade or activation of dopamine receptors

1993 • 79 citations

Regulation of DOPA Decarboxylase Activity in Brain of Living Rat

1995 • 75 citations

Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge

2006 • 74 citations

Effect of partial volume correction on estimates of the influx and cerebral metabolism of 6‐[ ¹⁸ F]fluoro‐ <scp>L</scp> ‐dopa studied with PET in normal control and Parkinson's disease subjects

2000 • 70 citations

Effect of partial volume correction on estimates of the influx and cerebral metabolism of 6-[18F]fluoro-L-dopa studied with PET in normal control and Parkinson's disease subjects

2000 • 57 citations

In Vivo Regulation of DOPA Decarboxylase by Dopamine Receptors in Rat Brain

1997 • 52 citations

The Distribution and Kinetics of [¹⁸F]6-Fluoro-3-O-Methyl-l-Dopa in the Human Brain

1994 • 41 citations

Diagnosing schizophrenia in the initial prodromal phase

2000 • 35 citations

Schizophrenia is associated with increased synaptic dopamine in associative rather than limbic regions of the striatum: Implications for mechanisms of action of antipsychotic drugs

2006 • 20 citations