SEROTONIN 5-HT2C RECEPTOR AGONISTS: POTENTIAL FOR THE TREATMENT OF OBESITY

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Valvular Heart Disease Associated with Fenfluramine–Phentermine

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1995 • 240 citations

Identification, Expression, and Pharmacology of a Cys23-Ser23 Substitution in the Human 5-HT2C Receptor Gene (HTR2C)

1995 • 223 citations

Identification of polymorphic loci in the promoter region of the serotonin 5-HT 2C receptor gene and their association with obesity and Type II diabetes

2000 • 215 citations

Gateways to clinical trials.

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Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors

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Serotonin 5‐HT_2C Receptor RNA Editing Alters Receptor Basal Activity

1999 • 180 citations

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5-HT 2C receptor activation decreases appetite and body weight in obese subjects

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Weight gain associated with the −759C/T polymorphism of the 5HT2C receptor and olanzapine

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Low Gene Expression Conferred by Association of an Allele of the 5-HT_2CReceptor Gene With Antipsychotic-Induced Weight Gain

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Lack of association between the –759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals

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A 5‐HT_2C receptor promoter polymorphism (HTR2C − 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes

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Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

2005 • 82 citations

Oral administration of the 5-HT2C receptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia

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Comparative effects of continuous infusion of mCPP, Ro 60‐0175 and d‐fenfluramine on food intake, water intake, body weight and locomotor activity in rats

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Phospholipase D Activation by Endogenous 5-Hydroxytryptamine 2C Receptors Is Mediated by Gα₁₃and Pertussis Toxin-Insensitive Gβγ Subunits

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Receptor-mediated contraction of aortic valve leaflets.

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Serotonin 5‐HT_2C Receptor Stimulates Cyclic GMP Formation in Choroid Plexus

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Indoline derivatives as 5-HT 2C receptor agonists

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1997 • 45 citations

Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats

2004 • 45 citations

5‐HT_1B receptor knockout mice show a compensatory reduction in 5‐HT_2C receptor function

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Pharmacological properties of the Cys23Ser single nucleotide polymorphism in human 5-HT2C receptor isoforms

2005 • 39 citations

Synthesis and 5-Hydroxytryptamine (5-HT) activity of 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-Hexahydro-1H-pyrazino[1,2-a]quinoxalines

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Central G-Protein Coupled Receptors (GPCR)s as Molecular Targets for the Treatment of Obesity: Assets, Liabilities and Development Status

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Metabolic Syndrome Targets

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Chapter 1. Promise and progress of central G-protein coupled receptor modulators for obesity treatments

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