Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

Growth Factors and Cancer

1991 • 2,044 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites

1988 • 508 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts.

1991 • 449 citations

Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies

1984 • 443 citations

Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites

1988 • 405 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Intermolecular association of the p185 protein and EGF receptor modulates EGF receptor function

1990 • 362 citations

Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

1988 • 357 citations

Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels.

1984 • 279 citations

?Seed and soil? revisited: mechanisms of site-specific metastasis

1982 • 276 citations

Specificity of adhesion between murine tumor cells and capillary endothelium: an in vitro correlate of preferential metastasis in vivo.

1987 • 250 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

1991 • 217 citations

Estrogen Receptors and Responses to Chemotherapy and Hormonal Therapy in Advanced Breast Cancer

1978 • 207 citations

Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.

1987 • 199 citations

Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas

1989 • 190 citations

Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer.

1991 • 187 citations

Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma.

1990 • 185 citations

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

1992 • 168 citations

Cancer Progression and Growth: Relationship of Paracrine and Autocrine Growth Mechanisms to Organ Preference of Metastasis

1993 • 157 citations

Differential expression of cell surface glycoproteins on various organ‐derived microvascular endothelia and endothelial cell cultures

1988 • 155 citations

Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors

1987 • 145 citations

Organ specificity of metastatic tumor colonization is related to organ‐selective growth properties of malignant cells

1986 • 145 citations

Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.

1989 • 136 citations

Migration of tumor cells to organ-derived chemoattractants.

1985 • 135 citations

Autocrine and paracrine growth regulation of human breast cancer

1986 • 135 citations

Clonal drift of cell surface, melanogenic, and experimental metastatic properties of in vivo-selected, brain meninges-colonizing murine B16 melanoma.

1982 • 127 citations

Growth-Regulatory Factors for Normal, Premalignant, and Malignant Human Cells In Vitro

1990 • 117 citations

Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis

1992 • 114 citations

Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials

1993 • 112 citations

Microvascular endothelial cell heterogeneity: Interactions with leukocytes and tumor cells

1990 • 104 citations

Molecular mechanisms of cancer metastasis

1991 • 103 citations

Characterization and quantitation of the epidermal growth factor receptor in invasive and superficial bladder tumors.

1989 • 101 citations

Heparan sulfate and heparin as a potentiator or a suppressor of growth of normal and transformed vascular endothelial cells

1987 • 89 citations

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.

1991 • 87 citations

Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products.

1992 • 85 citations

Analysis of Organ-Specific Effects on Metastatic Tumor Formation by Studies In Vitro<xref ref-type="fn" rid="FN1">2</xref>

1986 • 82 citations

Growth factors in melanoma

1991 • 81 citations

Direct in vitro lysis of metastatic tumor cells by cytokine-activated murine vascular endothelial cells.

1991 • 79 citations

Selective stimulation of prostatic carcinoma cell proliferation by transferrin.

1992 • 76 citations

Purification and some properties of a lung-derived growth factor that differentially stimulates the growth of tumor cells metastatic to the lung.

1989 • 73 citations

Clonal growth of tumors on tissue-specific biomatrices and correlation with organ site specificity of metastases.

1989 • 72 citations

Aberrant expression of the c-erbB-2/neu protooncogene in ovarian cancer

1992 • 69 citations

Themotaxis of metastatic tumor cells

1982 • 67 citations

Organ specific metastasis with special reference to avian systems

1983 • 65 citations

Adhesive, invasive, and growth properties of selected metastatic variants of a murine large-cell lymphoma.

1989 • 61 citations

Development of invasive and growth factor-independent cell variants from primary human melanomas.

1991 • 58 citations

Growth regulation of cancer metastases by their host organ.

1988 • 51 citations

Clonal Stimulation or Inhibition of Human Colon Carcinomas and Human Renal Carcinomas Mediated by Transforming Growth Factor-β 1

1989 • 49 citations

Mast cell modulation of tumour cell proliferation in rat mammary adenocarcinoma 13762NF

1991 • 48 citations

Ha-ras induction of the invasive phenotype results in up-regulation of epidermal growth factor receptors and altered responsiveness to epidermal growth factor in human papillary transitional cell carcinoma cells.

1991 • 47 citations

Growth in an organ microenvironment as a selective process in metastasis

1988 • 47 citations

Differential growth properties of metastatic large-cell lymphoma cells in target organ-conditioned medium

1987 • 46 citations

Differential effects of transforming growth factor beta 1 on the growth of poorly and highly metastatic murine melanoma cells.

1990 • 44 citations

Differential organ tissue adhesion, invasion, and growth properties of metastatic rat mammary adenocarcinoma cells

1988 • 43 citations

Transferrin and the Growth-Promoting Effect of Nerves

1988 • 43 citations

Mesenchymal-epithelial interactions between normal and transformed human bladder cells.

1989 • 41 citations

Lung‐derived growth factor that stimulates the growth of lung‐metastasizing tumor cells: Identification as transferrin

1991 • 41 citations

Coincidental Acquisition of Growth Autonomy and Metastatic Potential During the Malignant Transformation of Factor-Dependent CCL39 Lung Fibroblasts

1988 • 39 citations

Immunology of metastasis

1983 • 38 citations

Differential Adhesion of Metastatic Rat Mammary Carcinoma Cells to Organ-Derived Microvessel Endothelial Cells and Subendothelial Matrix

1989 • 37 citations

Growth stimulating activity of lung extract on lung-colonizing colon 26 clones and its partial characterization

1988 • 37 citations

Antitumor effects of interleukin 6-Pseudomonas exotoxin chimeric molecules against the human hepatocellular carcinoma, PLC/PRF/5 in mice.

1991 • 36 citations

Differential expression of a Mr approximately 90,000 cell surface transferrin receptor-related glycoprotein on murine B16 metastatic melanoma sublines selected for enhanced brain or ovary colonization.

1990 • 35 citations

Stimulatory and inhibitory activities of lung-conditioned medium on the growth of normal and neoplastic cells in vitro.

1985 • 32 citations

Paracrine/autocrine growth mechanisms in tumor metastasis.

1992 • 23 citations

Effects of tumor growth on host defenses

1986 • 20 citations

Experimental metastasis of mouse embryonal carcinoma cell lines to specific locations.

1987 • 20 citations

Transfection of activated c-H-rasEJ/pSV2neo or pSV2neo genes into rat mammary cells: rapid stimulation of clonal diversification of spontaneous metastatic and cell-surface properties.

1992 • 19 citations

Brain surface invasion and metastasis of murine malignant melanoma variants

1987 • 17 citations

Growth factor modulation of metastatic lung colonization.

1990 • 14 citations

Effects of glycosaminoglycans and extracellular matrix components on metastatic rat rhabdomyosarcoma tumor and myoblast cell proliferation

1990 • 14 citations

Differential stimulation of the growth of lung-metastasizing tumor cells by lung (paracrine) growth factors: identification of transferrin-like mitogens in lung tissue-conditioned medium.

1992 • 13 citations

Adenovirus Type 5 E1A Gene Products Act as Transformation Suppressors of the neu Oncogene

1991 • 12 citations

The cytostatic activity of cultured Kupffer cells

1985 • 11 citations

Preferential growth stimulation of metastatic rat mammary adenocarcinoma cells by organ-derived syngeneic fibroblasts in vitro.

1992 • 5 citations