Opposite role of δ1- and δ2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for δ-opioid receptor heterogeneity

Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

1953 • 1,702 citations

A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphate

1971 • 1,547 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

1988 • 599 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist.

1986 • 544 citations

Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.

1991 • 330 citations

Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.

1991 • 265 citations

The role of CCK, caerulein, and CCK antagonists in nociception

1989 • 246 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.

1991 • 231 citations

A highly selective δ1-opioid receptor antagonist: 7-benzylidenenaltrexone

1992 • 182 citations

Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes

1984 • 168 citations

Demonstration and Characterization of Opiate Inhibition of the Striatal Adenylate Cyclase

1981 • 149 citations

Mixed-inhibitor-prodrug as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

1992 • 139 citations

Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.

1992 • 116 citations

Opiate receptors

1995 • 110 citations

Co-localization of enkephalin and cholecystokinin in discrete areas of rat brain

1987 • 107 citations

Regional Distribution of Calcitonin Gene‐Related Peptide‐, Substance P‐, Cholecystokinin‐, Met⁵‐Enkephalin‐, and Dynorphin A (1–8)‐Like Materials in the Spinal Cord and Dorsal Root Ganglia of Adult Rats: Effects of Dorsal Rhizotomy and Neonatal Capsaicin

1990 • 105 citations

Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

1980 • 102 citations

Opiate binding to membrane preparations of neuroblastoma X glioma hybrid cells NG108-15: Effects of ions and nucleotides

1978 • 97 citations

Role of spacer and address components in peptidomimetic .delta.-opioid receptor antagonists related to naltrindole

1991 • 97 citations

The μ rather than the δ subtype of opioid receptors appears to be involved in enkephalin-induced analgesia

1984 • 95 citations

Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.

1994 • 90 citations

Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain

1993 • 90 citations

Analgesic activity of intracerebroventricular administration of morphiceptin and β-casomorphins: Correlation with the morphine (μ) receptor binding affinity

1982 • 90 citations

Differential Regulation of D₁ Dopamine Receptor‐ and of A_2a Adenosine Receptor‐Stimulated Adenylyl Cyclase by μ‐, δ₁‐, and δ₂‐Opioid Agonists in Rat Caudate Putamen

1995 • 89 citations

In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain

1985 • 87 citations

Modulation of μ-mediated antinociception by δ agonists: characterization with antagonists

1989 • 86 citations

Evidence of the preferential involvement of .mu.-receptors in analgesia using enkephalins highly selective for peripheral .mu. or .delta. receptors

1981 • 72 citations

Treatment with antisense oligodeoxynucleotide to the opioid δ receptor selectively inhibits δ2-agonist antinociception

1994 • 72 citations

Differences in Binding Properties of μ and δ Opioid Receptor Subtypes from Rat Brain: Kinetic Analysis and Effects of Ions and Nucleotides

1985 • 66 citations

Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for .delta. opioid receptors

1988 • 62 citations

Potentiation of enkephalin action by peptidase inhibitors in rat locus ceruleus in vitro.

1987 • 59 citations

Differential inhibitory/stimulatory modulation of spinal CCK release by μ and δ opioid agonists, and selective blockade of μ-dependent inhibition by κ receptor stimulation

1991 • 58 citations

Association of the peptidase inhibitor RB 101 and a CCK-B antagonist strongly enhances antinociceptive responses

1993 • 56 citations

Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor

1994 • 55 citations

Role of the spacer in conferring .kappa. opioid receptor selectivity to bivalent ligands related to norbinaltorphimine

1991 • 51 citations

Evidence for delta opioid receptor subtypes regulating adenylyl cyclase activity in rat brain

1994 • 46 citations

Cross-tolerance studies in the spinal cord of β-FNA-treated mice provides further evidence for delta opioid receptor subtypes

1991 • 40 citations

Stimulation of δ‐Opioid Receptors Reduces the In Vivo Binding of the Cholecystokinin (CCK)‐B‐Selective Agonist [³H]pBC 264: Evidence for a Physiological Regulation of CCKergic Systems by Endogenous Enkephalins

1992 • 37 citations

Comparative binding properties of linear and cyclic δ‐selective enkephalin analogues: [³H]‐[D‐Thr², Leu⁵] enkephalyl‐Thr⁶ and [³H]‐[D‐Pen², D‐Pen⁵] enkephalin

1985 • 36 citations

Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.

1994 • 33 citations

Differential regulation of adenylyl cyclase activity by mu and delta opioids in rat caudate putamen and nucleus accumbens.

1993 • 32 citations

Cholecystokinin-A but not cholecystokinin-B receptor stimulation induces endogenous opioid-dependent antinociceptive effects in the hot plate test in mice

1993 • 32 citations

Systemic administration of (Tyr-D-Ser(O-tert-butyl)-Gly-Phe-Leu-Thr(O-tert-butyl), a highly selective delta opioid agonist, induces mu receptor-mediated analgesia in mice.

1991 • 30 citations

In vivo release of CCK‐8 from the dorsal horn of the rat: Inhibition by DAGOL

1989 • 27 citations

Mu- and delta-opioid receptors inhibitorily linked to dopamine-sensitive adenylate cyclase in rat striatum display a selectivity profile toward endogenous opioid peptides different from that of presynaptic mu, delta and kappa receptors.

1993 • 25 citations

Mu and delta opioid receptors mediate opposite modulations by morphine of the spinal release of cholecystokinin-like material

1994 • 25 citations

Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity.

1993 • 22 citations

ChemInform Abstract: EVIDENCE OF THE PREFERENTIAL INVOLVEMENT OF μ‐RECEPTORS IN ANALGESIA USING ENKEPHALINS HIGHLY SELECTIVE FOR PERIPHERAL μ OR Δ RECEPTORS

1982 • 21 citations

Morphine action on cholecystokinin octapeptide release from rat periaqueductal grey slices: Sensitisation by naloxone

1987 • 18 citations

Differential modulation of μ-opioid receptor-mediated antitussive activity by δ-opioid receptor agonists in mice

1993 • 18 citations

Opioid‐Inhibited Adenylyl Cyclase in Rat Brain Membranes: Lack of Correlation with High‐Affinity Opioid Receptor Binding Sites

1992 • 12 citations