Modulation of μ-mediated antinociception by δ agonists: characterization with antagonists

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE

1957 • 1,523 citations

Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

1979 • 684 citations

The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats.

1963 • 537 citations

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1981 • 503 citations

Manual of Pharmacologic Calculations

1986 • 425 citations

Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

1984 • 417 citations

ICI 174864: A highly selective antagonist for the opioid Δ-receptor

1984 • 361 citations

Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.

1982 • 296 citations

A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities

1980 • 287 citations

Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors

1980 • 249 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Site-directed alkylation of multiple opioid receptors. I. Binding selectivity.

1984 • 200 citations

Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.

1979 • 191 citations

Selective antagonists at the opiate delta-receptor

1982 • 170 citations

Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5] enkephalin in the mouse

1988 • 169 citations

Irreversible opiate agonists and antagonists: the 14-hydroxydihydromorphinone azines.

1982 • 164 citations

Interconverting mu and delta forms of the opiate receptor in rat striatal patches.

1981 • 159 citations

Naloxonazine actions in vivo

1986 • 159 citations

Irreversible opiate agonists and antagonists: the 14- hydroxydihydromorphinone azines

1982 • 156 citations

Relative involvement of mu, kappa and delta receptor mechanisms in opiate-mediated antinociception in mice.

1983 • 153 citations

Opioid δ-receptor involvement in supraspinal and spinal antinociception in mice

1987 • 139 citations

Dissociation of opioid antinociception and central gastrointestinal propulsion in the mouse: studies with naloxonazine.

1988 • 126 citations

beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.

1988 • 123 citations

Allosteric coupling between morphine and enkephalin receptors in vitro.

1982 • 116 citations

Purification of an active opioid-binding protein from bovine striatum.

1985 • 106 citations

Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

1980 • 102 citations

Modulation of μ-mediated antinociception by δ agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin

1989 • 99 citations

Evidence for the interaction of morphine with kappa and delta opioid receptors to induce analgesia in beta-funaltrexamine-treated mice.

1987 • 93 citations

Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.

1982 • 91 citations

A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site.

1985 • 75 citations

Multiple opioid receptors: Evidence for μ -δ binding site interactions in endotoxic shock

1983 • 75 citations

Autoradiographic evidence for two classes of mu opioid binding sites in rat brain using [125I]FK33824

1987 • 58 citations

[D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites

1986 • 53 citations

C57BL/6J-bg J (beige) mice: Differential sensitivity in the tail flick test to centrally administered MU- and delta-opioid receptor agonists

1987 • 41 citations

Chronic morphine upregulates a μ-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography

1987 • 34 citations

Leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to the opiate mu-recognition site: Evidence for delta←mu binding site interactions in vitro

1985 • 32 citations

Estimation of the affinity of naloxone at supraspinal and spinal opioid receptors in vivo: Studies with receptor selective agonists

1986 • 32 citations

The effects of receptor selective opioid peptides on morphine-induced analgesia

1982 • 30 citations

Effect of β‐FNA on Opiate δ Receptor Binding

1984 • 16 citations

Evidence that the delta-selective alkylating agent, FIT, alters the mu-noncompetitive opiate delta binding site

1985 • 16 citations

Ionic conditions differentially affect 3H-DADL binding to type-I and type-II opiate delta receptors in vitro

1984 • 5 citations