Organization of the gene encoding the human beta-hexosaminidase alpha-chain.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Lysosomes in biology and pathology

1977 • 2,068 citations

Plasmid screening at high colony density

1980 • 1,100 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

1980 • 809 citations

Speculations on RNA splicing

1981 • 639 citations

Genes-in-Pieces Revisited

1985 • 362 citations

Alkaline transfer of DNA to plastic membrane

1984 • 285 citations

Rapid restriction mapping of DNA cloned in lambda phage vectors

1984 • 250 citations

Evidence for two different active sites on human beta-hexosaminidase A. Interaction of GM2 activator protein with beta-hexosaminidase A.

1985 • 223 citations

Nucleotide sequence of the human parathyroid hormone gene.

1983 • 206 citations

Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease.

1986 • 176 citations

Lysosomal Enzyme Precursors in Human Fibroblasts. Activation of Cathepsin D Precursor in vitro and Activity of beta-Hexosaminidase A Precursor towards Ganglioside GM2

1982 • 163 citations

Human beta-hexosaminidase alpha chain: coding sequence and homology with the beta chain.

1985 • 162 citations

Rapid purification of plasmid DNA by a single centrifugation in a two-step cesium chloride-ethidium bromide gradient

1983 • 161 citations

Association of alpha- and beta-subunits during the biosynthesis of beta-hexosaminidase in cultured human fibroblasts.

1984 • 159 citations

Molecular biology: Exons — present from the beginning?

1983 • 156 citations

Structure of a human gastrin gene.

1984 • 128 citations

A gene encoding rat cholecystokinin. Isolation, nucleotide sequence, and promoter activity.

1985 • 116 citations

Synthesis of beta-hexosaminidase in cell-free translation and in intact fibroblasts: an insoluble precursor alpha chain in a rare form of Tay-Sachs disease.

1982 • 113 citations

Different Mutations in Ashkenazi Jewish and Non-Jewish French Canadians with Tay-Sachs Disease

1986 • 105 citations

Identification of a variant of mucolipidosis III (pseudo-Hurler polydystrophy): a catalytically active N-acetylglucosaminylphosphotransferase that fails to phosphorylate lysosomal enzymes.

1981 • 91 citations

UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1-phosphotransferase. Partial purification and characterization of the rat liver Golgi enzyme.

1982 • 85 citations

Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector.

1984 • 68 citations

cDNA clone for the alpha-chain of human beta-hexosaminidase: deficiency of alpha-chain mRNA in Ashkenazi Tay-Sachs fibroblasts.

1984 • 64 citations

Faulty association of alpha- and beta-subunits in some forms of beta-hexosaminidase A deficiency.

1984 • 62 citations

The Biochemical Basis of Gangliosidoses

1984 • 59 citations

Evidence for two dissimilar polypeptide chains in the beta 2 subunit of hexosaminidase.

1982 • 50 citations

Exons of the human pancreatic polypeptide gene define functional domains of the precursor.

1985 • 46 citations

Genetic complementation in somatic cell hybrids of four variants of infantile GM2 gangliosidosis

1985 • 22 citations