High acetylcholine concentrations cause rapid inactivation before fast desensitization in nicotinic acetylcholine receptors from Torpedo

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*

1967 • 517 citations

Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization

1986 • 414 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Voltage jump analysis of procaine action at frog end‐plate

1977 • 230 citations

Desensitization at the frog neuromuscular junction: a biphasic process

1982 • 211 citations

The charge carried by single‐channel currents of rat cultured muscle cells in the presence of local anaesthetics.

1983 • 211 citations

Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction

1985 • 187 citations

Agonists block currents through acetylcholine receptor channels

1984 • 185 citations

A study of desensitization of acetylcholine receptors using nerve‐released transmitter in the frog

1981 • 172 citations

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

1980 • 170 citations

Decamethonium both opens and blocks endplate channels.

1978 • 168 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra alpha-toxin.

1980 • 140 citations

Kinetics of binding of [3H]acetylcholine and [3H]carbamoylcholine to Torpedo postsynaptic membranes: slow conformational transitions of the cholinergic receptor

1980 • 136 citations

Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization

1982 • 135 citations

Physiological and Pharmacological Manipulations with Light Flashes

1982 • 115 citations

Stoichiometry of the Ligand-Binding Sites in the Acetylcholine-Receptor Oligomer from Muscle and from Electric Organ. Measurement by Affinity Alkylation with Bromoacetylcholine

1980 • 110 citations

Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata

1983 • 108 citations

The channel‐blocking action of methonium compounds on rat submandibular ganglion cells

1997 • 98 citations

The channel‐blocking action of methonium compounds on rat submandibular ganglion cells

1984 • 97 citations

Acetylcholine Receptor-Controlled Ion Translocation: Chemical Kinetic Investigations of the Mechanism

1983 • 94 citations

High Resolution Mixer for the Study of the Kinetics of Rapid Reactions in Solution

1968 • 90 citations

A method for the rapid exchange of solutions bathing excised membrane patches

1986 • 87 citations

Activation and inactivation kinetics of Torpedo californica acetylcholine receptor in reconstituted membranes

1982 • 74 citations

Quenched flow technique with plasma membrane vesicles: Acetylcholine receptor-mediated transmembrane ion flux

1981 • 68 citations

Kinetics of binding of [3H]acetylcholine to Torpedo postsynaptic membranes: association and dissociation rate constants by rapid mixing and ultrafiltration

1980 • 66 citations

Two‐component desensitization at the neuromuscular junction of the frog.

1983 • 65 citations

Mechanism of inactivation (desensitization) of acetylcholine receptor. Investigations by fast reaction techniques with membrane vesicles

1981 • 60 citations

Activation and desensitization of Torpedo acetylcholine receptor: evidence for separate binding sites.

1982 • 58 citations

Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation

1986 • 56 citations

Trapping of an open-channel blocker at the frog neuromuscular acetylcholine channel

1986 • 54 citations

Comparison of acetylcholine receptor-controlled cation flux in membrane vesicles from Torpedo californica and Electrophorus electricus : Chemical kinetic measurements in the millisecond region

1982 • 53 citations

Acetylcholine receptor inactivation in torpedo californica electroplax membrane vesicles. Detection of two processes in the millisecond and second time regions

1981 • 50 citations

Acetylcholine receptor: evidence for a voltage-dependent regulatory site for acetylcholine. Chemical kinetic measurements in membrane vesicles using a voltage clamp

1983 • 44 citations

Acetylcholine-induced cation translocation across cell membranes and inactivation of the acetylcholine receptor: chemical kinetic measurements in the millisecond time region.

1981 • 39 citations

Regulatory properties of acetylcholine receptor. Evidence for two different inhibitory sites, one for acetylcholine and the other for a noncompetitive inhibitor of receptor function (procaine)

1984 • 35 citations

Acetylcholine receptor: characterization of the voltage-dependent regulatory (inhibitory) site for acetylcholine in membrane vesicles from Torpedo californica electroplax

1986 • 31 citations

Acetylcholine receptor: evidence for a regulatory binding site in investigations of suberyldicholine-induced transmembrane ion flux in Electrophorus electricus membrane vesicles

1983 • 30 citations

Acetylcholine receptor kinetics: Chemical kinetics

1986 • 29 citations

Sites of action of procaine at the motor end‐plate.

1983 • 26 citations

Is agonist self-inhibition at the nicotinic acetylcholine receptor a nonspecific action?

1987 • 23 citations

Direct spectrophotometric detection of cation flux in membrane vesicles: Stopped-flow measurements of acetylcholine-receptor-mediated ion flux

1983 • 23 citations

Movement of labelled decamethonium in muscle fibres of the rat.

1977 • 8 citations