Chemokines: Control of Primary and Memory T-Cell Traffic

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Human Chemokines: An Update

1997 • 2,235 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

International union of pharmacology. XXII. Nomenclature for chemokine receptors.

2000 • 1,771 citations

Effector and memory T-cell differentiation: implications for vaccine development

2002 • 1,757 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

T-Cell Function and Migration — Two Sides of the Same Coin

2000 • 1,437 citations

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

1997 • 1,406 citations

Homing and cellular traffic in lymph nodes

2003 • 1,233 citations

Lymphocyte traffic control by chemokines

2001 • 1,225 citations

Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

2000 • 1,188 citations

The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses

2000 • 1,077 citations

Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells

2003 • 1,058 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes

1998 • 1,001 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Chemokines: multiple levels of leukocyte migration control☆

2004 • 849 citations

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

1999 • 839 citations

CCL27–CCR10 interactions regulate T cell–mediated skin inflammation

2002 • 773 citations

Chemokine receptors: multifaceted therapeutic targets

2002 • 738 citations

The CC chemokine CCL20 and its receptor CCR6

2003 • 726 citations

Lymphocyte Trafficking and Regional Immunity

1999 • 686 citations

Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

1998 • 679 citations

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1997 • 656 citations

A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo

2000 • 643 citations

Dancing to the tune of chemokines

2001 • 624 citations

Cutting Edge: Secondary Lymphoid-Tissue Chemokine (SLC) and CC Chemokine Receptor 7 (CCR7) Participate in the Emigration Pathway of Mature Dendritic Cells from the Skin to Regional Lymph Nodes

1999 • 621 citations

Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

2000 • 620 citations

Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

2000 • 533 citations

Inflammatory Chemokine Transport and Presentation in HEV

2001 • 532 citations

Multistep Navigation and the Combinatorial Control of Leukocyte Chemotaxis

1997 • 531 citations

Understanding dendritic cell and T‐lymphocyte traffic through the analysis of chemokine receptor expression

2000 • 526 citations

Progressive differentiation and selection of the fittest in the immune response

2002 • 503 citations

CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells

1999 • 502 citations

CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin

2001 • 502 citations

Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis

1999 • 492 citations

Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues

2002 • 490 citations

Human Macrophage–derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer Cells

1997 • 486 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium

2000 • 464 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

Selective Generation of Gut Tropic T Cells in Gut-associated Lymphoid Tissue (GALT)

2003 • 448 citations

Identification of Vascular Lineage-Specific Genes by Transcriptional Profiling of Isolated Blood Vascular and Lymphatic Endothelial Cells

2003 • 444 citations

The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics

2001 • 442 citations

Phosphoinositide 3-kinase signalling – which way to target?

2003 • 412 citations

CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.

1999 • 404 citations

Linear Differentiation of Cytotoxic Effectors into Memory T Lymphocytes

1999 • 393 citations

The skin immune system: progress in cutaneous biology

1993 • 387 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9

2000 • 358 citations

Molecular Cloning of a Novel Human CC Chemokine Liver and Activation-regulated Chemokine (LARC) Expressed in Liver

1997 • 354 citations

International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature

2002 • 346 citations

The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System

2000 • 336 citations

Persistent Induction of the Chemokine Receptor CXCR4 by TGF-β1 on Synovial T Cells Contributes to Their Accumulation Within the Rheumatoid Synovium

2000 • 328 citations

CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells

2003 • 328 citations

Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)

2000 • 327 citations

A Role for CCR9 in T Lymphocyte Development and Migration

2002 • 321 citations

CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa

2002 • 313 citations

Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

2003 • 312 citations

The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7

1998 • 311 citations

Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues

2000 • 310 citations

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

2003 • 307 citations

Molecular Cloning of a Novel T Cell-directed CC Chemokine Expressed in Thymus by Signal Sequence Trap Using Epstein-Barr Virus Vector

1996 • 304 citations

Active movement of T cells away from a chemokine

2000 • 293 citations

TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development

1997 • 292 citations

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes

2001 • 291 citations

Cloning and Characterization of a Specific Receptor for the Novel CC Chemokine MIP-3α from Lung Dendritic Cells

1997 • 289 citations

Regional specialization in the mucosal immune system: primed cells do not always home along the same track

1999 • 287 citations

Identification of a Novel Chemokine (CCL28), which Binds CCR10 (GPR2)

2000 • 285 citations

Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells

2000 • 285 citations

Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin

2002 • 274 citations

Macrophage Inflammatory Protein 3α Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells

1999 • 272 citations

Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa

2000 • 252 citations

Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes

2002 • 244 citations

Stromal-Cell Derived Factor Is Expressed by Dendritic Cells and Endothelium in Human Skin

1999 • 243 citations

Regulated MIP-3α/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity

2001 • 227 citations

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

2001 • 218 citations

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

1999 • 217 citations

CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking

2003 • 210 citations

Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans

1999 • 207 citations

C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential

2001 • 205 citations

T Cell Death and Memory

2001 • 204 citations

Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation

2000 • 196 citations

Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites

1994 • 192 citations

Naive T Cell Recruitment to Nonlymphoid Tissues: A Role for Endothelium-Expressed CC Chemokine Ligand 21 in Autoimmune Disease and Lymphoid Neogenesis

2003 • 190 citations

Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by epidermal keratinocytes and its role in atopic dermatitis

2001 • 188 citations

How Do Lymphocytes Know Where to Go: Current Concepts and Enigmas of Lymphocyte Homing

1997 • 187 citations

CD4+ T cell effectors can become memory cells with high efficiency and without further division

2001 • 186 citations

Chemokines and Their Receptors in Lymphocyte Traffic and HIV Infection

1999 • 184 citations

Lymphocyte Homing to Bronchus-associated Lymphoid Tissue (BALT) Is Mediated by L-selectin/PNAd, α4β1 Integrin/VCAM-1, and LFA-1 Adhesion Pathways

2003 • 179 citations

Cloning and Characterization of Exodus, a Novel β-Chemokine

1997 • 176 citations

Tumor Necrosis Factor–dependent Segmental Control of MIG Expression by High Endothelial Venules in Inflamed Lymph Nodes Regulates Monocyte Recruitment

2001 • 176 citations

Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation

1999 • 174 citations

Expression of Chemokine Receptors by Lung T Cells from Normal and Asthmatic Subjects

2001 • 171 citations

The Transmembrane Form of the CX3CL1 Chemokine Fractalkine Is Expressed Predominantly by Epithelial Cells in Vivo

2001 • 168 citations

IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and their roles in atopic dermatitis

2002 • 158 citations

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

2000 • 155 citations

Proliferation Requirements of Cytomegalovirus-Specific, Effector-Type Human CD8+ T Cells

2002 • 149 citations

Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease

2002 • 148 citations

Fractalkine receptor expression by T lymphocyte subpopulations andin vivo production of fractalkine in human

2000 • 138 citations

Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration

2003 • 125 citations

Immune Surveillance and Effector Functions of CCR10+ Skin Homing T Cells

2002 • 121 citations

T cell immunity in lymphoid and non-lymphoid tissues

2002 • 117 citations

Skin‐versus gut‐skewed homing receptor expression and intrinsic CCR4 expression on human peripheral blood CD4⁺CD25⁺ suppressor T cells

2003 • 112 citations

CC Chemokine Receptor 9 Expression Defines a Subset of Peripheral Blood Lymphocytes with Mucosal T Cell Phenotype and Th1 or T-Regulatory 1 Cytokine Profile

2003 • 112 citations

CXCR5+ T cells: follicular homing takes center stage in T-helper-cell responses

2002 • 111 citations

Cutting Edge: C-C Chemokine Receptor 6 Is Essential for Arrest of a Subset of Memory T Cells on Activated Dermal Microvascular Endothelial Cells Under Physiologic Flow Conditions In Vitro

2000 • 111 citations

Macrophage-Derived Chemokine (MDC/CCL22) and CCR4 Are Involved in the Formation of T Lymphocyte-Dendritic Cell Clusters in Human Inflamed Skin and Secondary Lymphoid Tissue

2001 • 102 citations

Molecular Cloning and Functional Characterization of a Novel CC Chemokine, Stimulated T Cell Chemotactic Protein (STCP-1) That Specifically Acts on Activated T Lymphocytes

1997 • 102 citations

Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane‐bound chemokine expressed constitutively in diverse cells of the skin

2000 • 86 citations

Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin

2000 • 71 citations

Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen

2003 • 70 citations

The leukocyte cytoskeleton in cell migration and immune interactions

2002 • 66 citations

CCR4 in human allergen-induced late responses in the skin and lung

2002 • 63 citations

High level of thymus and activation-regulated chemokine in blister fluid and sera of patients with bullous pemphigoid

2003 • 59 citations

Preferential expression of Th2-type chemokine and its receptor in atopic dermatitis

2002 • 56 citations

Is Maturation Required for Langerhans Cell Migration?

2002 • 45 citations

Age‐Related Changes in CCR9⁺ Circulating Lymphocytes: Are CCR9⁺ Naive T Cells Recent Thymic Emigrants?

2001 • 27 citations

Identification of a novel β-chemokine, MEC, down-regulated in primary breast tumors

2001 • 18 citations