New structural insights into lectin-type proteins of the immune system

The Protein Data Bank

2000 • 35,287 citations

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

Lectins: Carbohydrate-Specific Proteins That Mediate Cellular Recognition

1998 • 1,707 citations

A new receptor for β-glucans

2001 • 1,498 citations

The C‐type lectin superfamily in the immune system

1998 • 1,022 citations

Structure of a C-type mannose-binding protein complexed with an oligosaccharide

1992 • 873 citations

Selectins.

1993 • 869 citations

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages

2000 • 864 citations

Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1

2000 • 704 citations

The mannose receptor is a pattern recognition receptor involved in host defense

1998 • 640 citations

C-type lectin-like domains

1999 • 609 citations

Structure of the Calcium-Dependent Lectin Domain from a Rat Mannose-Binding Protein Determined by MAD Phasing

1991 • 547 citations

Engineering galactose-binding activity into a C-type mannose-binding protein

1992 • 470 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning

2000 • 457 citations

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding

1995 • 435 citations

Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains

1994 • 397 citations

Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA

2001 • 389 citations

PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus

1995 • 383 citations

Crystal structure of a bacterial chitinase at 2.3 Å resolution

1994 • 382 citations

Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

1993 • 332 citations

Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration

1996 • 313 citations

Tyrosine Sulfation of P-selectin Glycoprotein Ligand-1 Is Required for High Affinity Binding to P-selectin

1995 • 290 citations

Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand

1999 • 260 citations

A Macrophage Protein, Ym1, Transiently Expressed during Inflammation Is a Novel Mammalian Lectin

2001 • 246 citations

CD69 and Regulatiof the Immune Function

1999 • 223 citations

Structural Basis of Galactose Recognition by C-type Animal Lectins

1996 • 202 citations

Ca2+-dependent carbohydrate-recognition domains in animal proteins

1993 • 200 citations

Oligosaccharides that mediate mammalian cell-cell adhesion

1993 • 197 citations

Crystal Structure of the Carbohydrate Recognition Domain of the H1 Subunit of the Asialoglycoprotein Receptor

2000 • 185 citations

Conformation of sLe^x Tetrasaccharide, Free in Solution and Bound to E-, P-, and L-Selectin^,

1997 • 172 citations

A cysteine-rich domain of the “mannose” receptor mediates GalNAc-4-SO ₄ binding

1998 • 170 citations

Adhesion : its role in inflammatory disease

1992 • 167 citations

Structural Analysis of Monosaccharide Recognition by Rat Liver Mannose-binding Protein

1996 • 165 citations

The Cysteine-Rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates a and B and Sulfated Oligosaccharides of Blood Group Lewisa and Lewisx Types in Addition to the Sulfated N-Glycans of Lutropin

2000 • 164 citations

The C-type carbohydrate recognition domain (CRD) superfamily

1994 • 141 citations

Structure of a C-type Carbohydrate Recognition Domain from the Macrophage Mannose Receptor

2000 • 132 citations

The Conformation of the Sialyl Lewis X Ligand Changes upon Binding to E-Selectin

1994 • 123 citations

Crystal Structure of the Cysteine-Rich Domain of Mannose Receptor Complexed with a Sulfated Carbohydrate Ligand

2000 • 121 citations

Eosinophil-fibroblast interactions. Granule major basic protein interacts with IL-1 and transforming growth factor-beta in the stimulation of lung fibroblast IL-6-type cytokine production.

1996 • 115 citations

Determination of the Bioactive Conformation of the Carbohydrate Ligand in the E‐Selectin/Sialyl Lewis^X Complex

1995 • 109 citations

MINI REVIEW Carbohydrate sulfotransferases in lymphocyte homing

2000 • 106 citations

The Crystal Structure of a Novel Mammalian Lectin, Ym1, Suggests a Saccharide Binding Site

2001 • 99 citations

Mechanism of Ca2- and Monosaccharide Binding to a C-type Carbohydrate-recognition Domain of the Macrophage Mannose Receptor

1997 • 97 citations

New animal lectin structures

1999 • 96 citations

The structure of a tunicate C-type lectin from polyandrocarpa misakiensis complexed with d-galactose

1999 • 94 citations

Localization and characterization of the hyaluronan-binding site on the Link module from human TSG-6

2000 • 93 citations

The Functional Binding Site for the C-Type Lectin–Like Natural Killer Cell Receptor Ly49a Spans Three Domains of Its Major Histocompatibility Complex Class I Ligand

2001 • 92 citations

Crystal structure of the murine NK cell–activating receptor NKG2D at 1.95 Å

2001 • 87 citations

Crystal Structure of the C-type Lectin-like Domain from the Human Hematopoietic Cell Receptor CD69

2001 • 81 citations

Sialyl-LewisxSequence 6-O-Sulfated atN-Acetylglucosamine Rather Than at Galactose Is the Preferred Ligand forl-Selectin and De-N-acetylation of the Sialic Acid Enhances the Binding Strength

1997 • 80 citations

5 Nanosecond molecular dynamics and NMR study of conformational transitions in the sialyl-Lewis X antigen

1994 • 70 citations

Crystal Structure of Human CD69: A C-Type Lectin-Like Activation Marker of Hematopoietic Cells^,

2000 • 68 citations

Mechanism of pH-dependentN-Acetylgalactosamine Binding by a Functional Mimic of the Hepatocyte Asialoglycoprotein Receptor

2000 • 63 citations

Stable-Isotope-Assisted NMR Studies on ¹³C-Enriched Sialyl Lewis^x in Solution and Bound to E-Selectin

1999 • 57 citations

Crystal Structure of the Eosinophil Major Basic Protein at 1.8 Å

2001 • 54 citations

Studies on the three-dimensional behaviour of the selectin ligands Lewis^a and sulphated Lewis^a using NMR spectroscopy and molecular dynamics simulations

1994 • 42 citations

Conformation of the oligosaccharide receptor for E‐selectin

1994 • 41 citations

Application of homonuclear 3D NMR experiments and 1D analogs to study the conformation of sialyl Lewis(x) bound to E-selectin.

1997 • 34 citations

The molecular mechanism of sulfated carbohydrate recognition by the cysteine-rich domain of mannose receptor11Edited by I. A. Wilson

2001 • 28 citations

Conformational Studies on the Selectin and Natural Killer Cell Receptor Ligands Sulfo- and Sialyl-lacto-N-fucopentaoses (SuLNFPII and SLNFPII) Using NMR Spectroscopy and Molecular Dynamics Simulations. Comparisons with the Nonacidic Parent Molecule LNFPII

1996 • 26 citations

The Ligand-Binding Loops in the Tunicate C-Type Lectin TC14 Are Rigid

2001 • 18 citations

NK cell receptors: Of missing sugar and missing self

2000 • 17 citations

Re-evaluation of Monosaccharide Binding Property of Recombinant Soluble Carbohydrate Recognition Domain of the Natural Killer Cell Receptor NKR-P1A

1999 • 15 citations

Expression in Escherichia coli, Folding in Vitro, and Characterization of the Carbohydrate Recognition Domain of the Natural Killer Cell Receptor NKR-P1A

2000 • 9 citations