The reovirus cell attachment protein possesses two independently active trimerization domains: Basis of dominant negative effects

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Identification of deletion mutations and three new genes at the familial polyposis locus

1991 • 769 citations

Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

1991 • 758 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Sigma 1 protein of mammalian reoviruses extends from the surfaces of viral particles

1988 • 378 citations

Protein σ1 is the reovirus cell attachment protein

1981 • 305 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

Sequential mechanism of refolding of carbonic anhydrase B

1987 • 199 citations

Pathogenesis of Viral Infections

1985 • 174 citations

Evidence for functional domains on the reovirus type 3 hemagglutinin

1982 • 159 citations

Immortalization of rat embryo fibroblasts by the cellular p53 oncogene.

1988 • 157 citations

Identification of the gene coding for the hemagglutinin of reovirus

1978 • 146 citations

Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1

1990 • 131 citations

Molecular structure of the cell-attachment protein of reovirus: correlation of computer-processed electron micrographs with sequence-based predictions

1990 • 118 citations

Sequence of reovirus haemagglutinin predicts a coiled-coil structure

1985 • 117 citations

Glycophorin is the reovirus receptor on human erythrocytes

1987 • 100 citations

Identification of conserved domains in the cell attachment proteins of the three serotypes of reovirus

1990 • 75 citations

Biochemical and biophysical characterization of the reovirus cell attachment protein σ1: Evidence that it is a homotrimer

1991 • 64 citations

High-level synthesis of biologically active reovirus protein σ1 in a mammalian expression vector system

1988 • 62 citations

Studies on reovirus receptors of L cells: Virus binding characteristics and comparison with reovirus receptors of erythrocytes

1984 • 59 citations

Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene which encodes the viral ceil attachment protein σ1

1984 • 56 citations

Analysis of functional domains on reovirus cell attachment protein σ1 using cloned s1 gene deletion mutants

1987 • 55 citations

Consider the coiled coil

1991 • 49 citations

The N-terminal quarter of reovirus cell attachment protein σ1 possesses intrinsic virion-anchoring function

1990 • 45 citations

The cell attachment proteins of type 1 and type 3 reovirus are differentially susceptible to trypsin and chymotrypsin

1989 • 39 citations

Conformational and functional analysis of the C-terminal globular head of the reovirus cell attachment protein

1991 • 38 citations

The N-terminal heptad repeat region of reovirus cell attachment protein σ1 is responsible for σ1 oligomer stability and possesses intrinsic oligomerization function

1991 • 38 citations

The incorporation of reovirus cell attachment protein σ1 into virions requires the N-terminal hydrophobic tail and the adjacent heptad repeat region

1991 • 36 citations

Site-directed mutagenesis of the C-terminal portion of reovirus protein σ1: Evidence for a conformation-dependent receptor binding domain

1992 • 34 citations

Purification and characterization of the reovirus cell attachment protein σ1

1987 • 30 citations

Reovirus protein σ1 translated in vitro, as well as truncated derivatives of it that lack up to two-thirds of its C-terminal portion, exists as two major tetrameric molecular species that differ in electrophoretic mobility

1990 • 30 citations

Biosynthesis of reovirus-specified polypeptides: Ribosome pausing during the translation of reovirus S1 mRNA

1992 • 28 citations

Trimerization of the reovirus cell attachment protein (σI) induces conformational changes in σI necessary for its cell-binding function

1991 • 20 citations

Suppression with a difference

1991 • 20 citations

Identification of the σ1S protein in reovirus serotype 2-infected cells with antibody prepared against a bacterial fusion protein

1989 • 11 citations