Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule

DETERMINATION OF BLOOD SUGAR

1945 • 1,816 citations

Structural-functional relationships in diabetic nephropathy.

1984 • 1,202 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

[72] Identification of regulatory elements of cloned genes with functional assays

1987 • 477 citations

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

1993 • 381 citations

Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis.

1988 • 311 citations

Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

1987 • 275 citations

Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule

1992 • 264 citations

The Extracellular Matrix in Diabetic Nephropathy

1993 • 256 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium

1991 • 243 citations

Renal interstitial expansion in insulin-dependent diabetes mellitus

1993 • 229 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Identification of Fructose 3-Phosphate in the Lens of Diabetic Rats

1990 • 208 citations

High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule

1990 • 196 citations

Structure and Function of the Kidney in Diabetic Glomerulosclerosis

1980 • 186 citations

The renal tubulointerstitium in diabetes mellitus

1991 • 169 citations

Immunohistochemical Localization of Aldose Reductase: II. Rat Eye and Kidney

1980 • 148 citations

Connective tissue in diabetes mellitus: biochemical alterations of the intercellular matrix with special reference to proteoglycans, collagens and basement membranes.

1985 • 127 citations

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland

1986 • 121 citations

The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation

1984 • 116 citations

Amadori glucose adducts modulate mesangial cell growth and collagen gene expression

1994 • 110 citations

Studies of Kidney and Muscle Biopsy Specimens from Identical Twins Discordant for Type I Diabetes Mellitus

1985 • 106 citations

Correlations between renal interstitium and level of serum creatinine

1977 • 106 citations

Diabetes-induced glomerular dysfunction: Links to a more reduced cytosolic ratio of NADH/NAD+

1992 • 105 citations

Renal tubular basement membrane and collagen type IV in diabetes mellitus

1993 • 98 citations

Reduction of Glomerular Hyperfiltration in Normoalbuminuric IDDM Patients by 6 mo of Aldose Reductase Inhibition

1991 • 79 citations

Intracellular signaling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells.

1991 • 77 citations

Effects of Polyol-Pathway Inhibition and Dietary myo-Inositol on Glomerular Hemodynamic Function in Experimental Diabetes Mellitus in Rats

1991 • 76 citations

Basal phosphatidylinositol turnover controls aortic Na+/K+ ATPase activity.

1986 • 74 citations

The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture

1991 • 72 citations

Increased steady-state levels of laminin B1 mRNA in kidneys of long-term streptozotocin-diabetic rats. No effect of an aldose reductase inhibitor.

1988 • 69 citations

Early increased renal procollagen α1(IV) mRNA levels in streptozotocin induced diabetes

1992 • 69 citations

Effects of Sorbinil on Glomerular Structure and Function in Long-Term–Diabetic Rats

1989 • 68 citations

Detection of specific mRNAs in single nephron segments by use of the polymerase chain reaction

1990 • 67 citations

Localization of aldose and aldehyde reductase in the kidney

1989 • 66 citations

Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.

1988 • 65 citations

The effect of aldose reductase inhibitors on glomerular prostaglandin production and urinary albumin excretion in experimental diabetes mellitus

1991 • 61 citations

Effect of myo-inositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose.

1991 • 57 citations

Aldose Reductase Inhibition and Glomerular Abnormalities in Diabetic Rats

1989 • 56 citations

The distribution of polyol:NADP oxidoreductase in mammalian tissues

1969 • 53 citations

Renal changes in long-term Type 1 (insulin-dependent) diabetic patients with and without clinical nephropathy: a light microscopic, morphometric study of autopsy material

1984 • 52 citations

Aldose reductase and sorbitol dehydrogenase distribution in rat kidney.

1977 • 49 citations

Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat

1988 • 41 citations

Identification of sorbitol 3-phosphate and fructose 3-phosphate in normal and diabetic human erythrocytes.

1990 • 41 citations

Aldose reductase activities in microdissected rat renal tubule segments

1989 • 41 citations

Effects of osmotic stress and hyperglycemia on aldose reductase gene expression in human renal proximal tubule cells

1992 • 26 citations

Role of insulin and IGF1 receptors in proliferation of cultured renal proximal tubule cells

1992 • 24 citations

Glomerular basement membrane thickening in streptozotocin diabetic rats despite treatment with an aldose reductase inhibitor

1989 • 22 citations

Immunogold studies of monomeric elements from the globular domain (NC1) of type IV collagen in renal basement membranes during experimental diabetes in the rat

1990 • 16 citations

Polyol Metabolism in Monkey‐Kidney Epithelial‐Cell Cultures

1974 • 13 citations

Elicitation of Sorbitol Accumulation in Cultured Human Proximal Tubule Cells by Elevated Glucose Concentrations

1990 • 10 citations

Kidney levels of mRNA encoding S and B2 laminin and α1(IV) collagen in diabetic rats fed an aldose reductase inhibitor

1991 • 1 citations