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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

Data up to Jan 2025

Published2011
Citations897
References51

Total Citations Per Year

Abstract

References (51)

IDH1andIDH2Mutations in Gliomas

2009 • 5,312 citations

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

2009 • 3,695 citations

World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone

2002 • 2,836 citations

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

2010 • 2,561 citations

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

2010 • 1,866 citations

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

2009 • 1,065 citations

Characterization of a newly derived human sarcoma cell line (HT-1080)

1974 • 681 citations

Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas

2006 • 536 citations

Characterization of R132H Mutation‐specific IDH1 Antibody Binding in Brain Tumors

2009 • 507 citations

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

2010 • 380 citations

IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

2010 • 375 citations

IDH mutations in glioma and acute myeloid leukemia

2010 • 354 citations

Genetic Analysis of Transforming Events That Convert Chronic Myeloproliferative Neoplasms to Leukemias

2010 • 312 citations

Cancer-associated IDH mutations: biomarker and therapeutic opportunities

2010 • 291 citations

Cartilage tumours and bone development: molecular pathology and possible therapeutic targets

2010 • 263 citations

Activating Gsα Mutations: Analysis of 113 Patients with Signs of McCune-Albright Syndrome—A European Collaborative Study

2004 • 259 citations

A mutant PTH/PTHrP type I receptor in enchondromatosis

2002 • 255 citations

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

2011 • 244 citations

Assessment of Interobserver Variability and Histologic Parameters to Improve Reliability in Classification and Grading of Central Cartilaginous Tumors

2008 • 233 citations

Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene

2010 • 212 citations

Somatic gene mutation and human disease other than cancer: An update

2010 • 202 citations

IDH2 Mutations in Patients with <scp>d</scp> -2-Hydroxyglutaric Aciduria

2010 • 190 citations

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

2010 • 188 citations

Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity

2011 • 167 citations

Enchondromatosis: insights on the different subtypes.

2010 • 127 citations

Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer

2010 • 126 citations

PTHR1 mutations associated with Ollier disease result in receptor loss of function

2008 • 114 citations

Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway

2009 • 112 citations

Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study

2010 • 98 citations

Molecular analysis of the INK4A/INK4A‐ARF gene locus in conventional (central) chondrosarcomas and enchondromas: indication of an important gene for tumour progression

2004 • 86 citations

Enchondromatosis (Ollier disease, Maffucci syndrome) is not caused by the PTHR1 mutation p.R150C

2004 • 75 citations

Ollier's disease and maffucci's syndrome: distinct entities or a continuum

1988 • 60 citations

Tiling resolution array-CGH shows that somatic mosaic deletion of the EXT gene is causative in EXT gene mutation negative multiple osteochondromas patients

2010 • 56 citations

cDNA expression profiling of chondrosarcomas: Ollier disease resembles solitary tumours and alteration in genes coding for components of energy metabolism occurs with increasing grade

2005 • 54 citations

Increased levels of hypoxia‐inducible factor‐1α are associated with Bcl‐xL expression, tumor apoptosis, and clinical outcome in chondrosarcoma

2010 • 46 citations

DO INTRACRANIAL NEOPLASMS DIFFER IN OLLIER DISEASE AND MAFFUCCI SYNDROME? AN IN-DEPTH ANALYSIS OF THE LITERATURE

2009 • 42 citations

Genome-wide analysis of Ollier disease: Is it all in the genes?

2011 • 39 citations

Identical Twins with Ollierʼs Disease and Intracranial Gliomas

1994 • 37 citations

A Case of Ollierʼs Disease Associated with Two Intracranial Gliomas

1987 • 36 citations

Diffuse brain stem tumor in an adolescent with multiple enchondromatosis (Ollier's disease)

1999 • 36 citations

A case of Ollier’s disease associated with two intracerebral low-grade gliomas

1999 • 32 citations

Simultaneous occurrence of a supra- and an infratentorial glioma in a patient with Ollier's disease: more evidence for non-mesodermal tumor predisposition in multiple enchondromatosis

1998 • 29 citations

Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease

2008 • 29 citations

D-2-hydroxyglutaric aciduria in association with spondyloenchondromatosis

2000 • 28 citations

Multiple enchondromatosis Ollier's disease with two primary brain tumors.

2004 • 27 citations

Multiple enchondromatosis (Ollier's disease) complicated by malignant astrocytoma

1991 • 25 citations

Spondyloenchondromatosis with D-2-hydroxyglutaric aciduria: a report of a second patient with this unusual combination

2003 • 25 citations

Case report 602

1990 • 19 citations

Acute myelogenous leukemia associated with Ollier disease

2006 • 19 citations

Acute lymphoid leukemia associated with Maffucci's syndrome.

1993 • 17 citations

Maffucci's syndrome with frontal lobe astrocytoma.

1990 • 14 citations

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and… (2011) – The Journal of Pathology | Metascience Observatory Explorer