IDH mutations in glioma and acute myeloid leukemia

The Hallmarks of Cancer

2000 • 27,569 citations

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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The 2007 WHO Classification of Tumours of the Central Nervous System

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An Integrated Genomic Analysis of Human Glioblastoma Multiforme

2008 • 5,528 citations

IDH1andIDH2Mutations in Gliomas

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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The Consensus Coding Sequences of Human Breast and Colorectal Cancers

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Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1996 • 2,327 citations

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

2009 • 2,156 citations

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

2010 • 1,866 citations

Genetic Pathways to Primary and Secondary Glioblastoma

2007 • 1,446 citations

Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey

2006 • 1,425 citations

Genetic Pathways to Glioblastoma

2004 • 1,230 citations

Epidemiology and etiology of gliomas

2005 • 1,200 citations

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

2009 • 1,104 citations

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

2009 • 1,065 citations

Analysis of the IDH1 codon 132 mutation in brain tumors

2008 • 996 citations

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

2009 • 976 citations

Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes

2004 • 883 citations

IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication

2010 • 764 citations

IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

2010 • 740 citations

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

2010 • 708 citations

Cancer as a metabolic disease

2010 • 607 citations

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

2009 • 586 citations

Characterization of R132H Mutation‐specific IDH1 Antibody Binding in Brain Tumors

2009 • 507 citations

Genetic alterations and signaling pathways in the evolution of gliomas

2009 • 426 citations

Epidemiology of Brain Tumors

2008 • 403 citations

Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity

2004 • 381 citations

IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

2010 • 375 citations

Structural Insights into Histone Demethylation by JMJD2 Family Members

2006 • 374 citations

IDH1mutations at residue p.R132 (IDH1^R132) occur frequently in high-grade gliomas but not in other solid tumors

2009 • 355 citations

Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas

2004 • 316 citations

Genetic Analysis of Transforming Events That Convert Chronic Myeloproliferative Neoplasms to Leukemias

2010 • 312 citations

IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis

2010 • 307 citations

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

2009 • 297 citations

The prognostic IDH1 R132 mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

2010 • 284 citations

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma

2009 • 271 citations

Impact of IDH1 R132 Mutations and an IDH1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: SNP rs11554137 Is an Adverse Prognostic Factor

2010 • 239 citations

Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation

2010 • 207 citations

Lessons learned in the development of targeted therapy for malignant gliomas

2007 • 196 citations

IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide

2009 • 188 citations

Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

2010 • 188 citations

p53-Mediated Inhibition of Angiogenesis Through Up-Regulation of a Collagen Prolyl Hydroxylase

2006 • 186 citations

IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms

2010 • 182 citations

Mutations in the d-2-Hydroxyglutarate Dehydrogenase Gene Cause d-2-Hydroxyglutaric Aciduria

2005 • 164 citations

Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system

2009 • 163 citations

Mutant Metabolic Enzymes Are at the Origin of Gliomas

2009 • 152 citations

Mitochondrial Metabolism and Cancer

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Peroxisomal NADP-Dependent Isocitrate Dehydrogenase. Characterization and Activity Regulation during Natural Senescence

1999 • 129 citations

NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in <scp>d</scp>‐2‐hydroxyglutaric aciduria

2002 • 127 citations

Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer

2010 • 126 citations

Acquisition of the Glioblastoma Phenotype during Astrocytoma Progression Is Associated with Loss of Heterozygosity on 10q25-qter

1999 • 126 citations

Isocitrate Dehydrogenase Mutations Are Rare in Pheochromocytomas and Paragangliomas

2009 • 125 citations

D‐2‐hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats

2003 • 112 citations

L-2-hydroxyglutaric aciduria and brain malignant tumors

2004 • 110 citations

Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation

2006 • 104 citations

Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study

2010 • 98 citations

Segregation of non-p.R132H mutations inIDH1in distinct molecular subtypes of glioma

2010 • 96 citations

Gossypol Prototype of Inhibitors Targeted to Dinucleotide Folds

2000 • 93 citations

Reversibility of the mitochondrial isocitrate dehydrogenase reaction in the perfused rat liver. Evidence from isotopomer analysis of citric acid cycle intermediates.

1994 • 90 citations

Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome

2009 • 86 citations

<scp>D</scp>‐2‐Hydroxyglutaric aciduria: Unravelling the biochemical pathway and the genetic defect

2006 • 85 citations

Molecular signatures classify astrocytic gliomas by IDH1 mutation status

2010 • 80 citations

VX-497: A novel, selective IMPDH inhibitor and immunosuppressive agent

2001 • 62 citations

HIF and fumarate hydratase in renal cancer

2007 • 57 citations

Cloning and Characterization of a Sulfonate/α-Ketoglutarate Dioxygenase from Saccharomyces cerevisiae

1999 • 57 citations

The pentose phosphate cycle is regulated by NADPHNADP ratio in rat liver

1985 • 52 citations

Identification and Functional Characterization of a Novel, Tissue-specific NAD+-dependent Isocitrate Dehydrogenase β Subunit Isoform

1999 • 50 citations

Systems-Based Design of Bi-Ligand Inhibitors of Oxidoreductases

2004 • 40 citations

Critical Role of Lys212 and Tyr140 in Porcine NADP-dependent Isocitrate Dehydrogenase

2003 • 37 citations

L-2 Hydroxyglutaric Aciduria: Proton Magnetic Resonance Spectroscopy and Diffusion Magnetic Resonance Imaging Findings

2003 • 35 citations

Identification of the d-enantiomer of 2-hydroxyglutaric acid in glutaric aciduria type II

1995 • 21 citations

Detection of isocitrate dehydrogenase 1 mutation R132H in myelodysplastic syndrome by mutation-specific antibody and direct sequencing

2010 • 19 citations

A Phase I Dose‐Ranging Study of the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of AVN944, an IMPDH Inhibitor, in Healthy Male Volunteers

2008 • 15 citations

Systems-Based Design of Bi-Ligand Inhibitors of OxidoreductasesFilling the Chemical Proteomic Toolbox

2004 • 12 citations

In vitro effects of gossypol on testicular lactic dehydrogenase-X and other dehydrogenases

1987 • 5 citations

Deleted Work

1955 • 0 citations