Immunology of inflammatory bowel disease

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Differential Cytokine Modulation and T Cell Activation by Two Distinct Classes of Thalidomide Analogues That Are Potent Inhibitors of TNF-α

1999 • 618 citations

IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells

1999 • 576 citations

Tumor necrosis factor α antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis

1999 • 473 citations

Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease

1999 • 399 citations

Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease

1998 • 381 citations

Resistance of Crohn’s Disease T Cells to Multiple Apoptotic Signals Is Associated with a Bcl-2/Bax Mucosal Imbalance

1999 • 347 citations

Thalidomide therapy for patients with refractory Crohn's disease: An open-label trial

1999 • 335 citations

Matrix metalloproteinase levels are elevated in inflammatory bowel disease

1999 • 321 citations

The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls

1999 • 313 citations

An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease

1999 • 290 citations

Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis

1999 • 269 citations

T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

1999 • 261 citations

Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

1999 • 255 citations

Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation

1997 • 252 citations

Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease

1998 • 216 citations

Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease

1999 • 206 citations

Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease

1997 • 202 citations

Hyperexpression of CD40 Ligand (CD154) in Inflammatory Bowel Disease and Its Contribution to Pathogenic Cytokine Production

1999 • 147 citations

Role of Bacterial Intimin in Colonic Hyperplasia and Inflammation

1999 • 145 citations

Serologic testing for inflammatory bowel disease

1999 • 115 citations

Increased Interleukin-8 (II-8) in Rectal Dialysate From Patients With Ulcerative Colitis: Evidence for A Biological Role for IL-8 in Inflammation of The Colon

1999 • 106 citations

Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury

1999 • 103 citations

Elevated serum vascular endothelial growth factor in children and young adults with Crohn's disease.

1999 • 87 citations

Anti-cardiolipin antibodies in patients with inflammatory bowel disease.

1999 • 80 citations

Microbial factors in chronic intestinal inflammation

1996 • 77 citations

Increased mucosal production of granulocyte colony‐stimulating factor is related to a delay in neutrophil apoptosis in Inflammatory Bowel disease

1999 • 72 citations

Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa

1999 • 69 citations

Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa

1999 • 62 citations

Clinical value of the detection of antibodies in the serum for diagnosis and treatment of inflammatory bowel disease

1998 • 53 citations

Growth factors in inflammatory bowel disease

2007 • 52 citations

Regulation of ICAM-1–mediated fibroblast–T cell reciprocal interaction: Implications for modulation of gut inflammation

1999 • 45 citations

Characterization of antigens from the human exocrine pancreatic tissue (Pag) relevant as target antigens for autoantibodies in Crohn's disease

1999 • 41 citations

Local and systemic liberation of proinflammatory cytokines in ulcerative colitis.

1999 • 40 citations

Antineutrophil Cytoplasmic Antibodies in Japanese Patients With Inflammatory Bowel Disease: Prevalence and Recognition of Putative Antigens

1999 • 35 citations

Vascular endothelial growth factor (VEGF) in Crohn's disease: increased production by peripheral blood mononuclear cells and decreased VEGF165 labeling of peripheral CD14+ monocytes.

1999 • 32 citations

Circulating antibodies to Saccharomyces cerevisiae (bakers'/brewers' yeast) in gastrointestinal disease

1999 • 24 citations

Autoantibodies to molecular targets in neutrophils in patients with ulcerative colitis.

1999 • 19 citations

Activation of Microvascular Endothelial Cells in Active Ulcerative Colitis and Detection of Inducible Nitric Oxide Synthase

1998 • 18 citations

Activation of nuclear factor κB as a target for anti- inflammatory therapy

1999 • 11 citations

Section editor's commentary. The role of panca and asca in differentiating ulcerative colitis, Crohn's disease, and indeterminate colitis

2007 • 9 citations

Anti-<i>Anisakis</i> Antibodies in the Clinical Course of Crohn’s Disease

1999 • 8 citations