Taurine modulates induction of cytochrome P450 3A4 mRNA by rifampicin in the HepG2 cell line

Physiological actions of taurine

1992 • 2,555 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 • 929 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR

1999 • 736 citations

TAURINE: BIOLOGICAL UPDATE

1986 • 571 citations

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

2000 • 565 citations

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes.

1992 • 536 citations

Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor-α Expression in Human Hepatocytes: Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators

2000 • 367 citations

Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors

2001 • 357 citations

Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture

1995 • 238 citations

Taurine: A role in osmotic regulation of mammalian brain and possible clinical significance

1980 • 205 citations

Taurine: its biological role and clinical implications.

1985 • 205 citations

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes

1993 • 182 citations

Taurine: Its Biological Role and Clinical Implications

1985 • 153 citations

Taurine as a neuromodulator.

1980 • 141 citations

Taurine protection of lymphoblastoid cells from iron-ascorbate induced damage

1985 • 140 citations

Hepatic Taurine Concentration and Dietary Taurine as Regulators of Bile Acid Conjugation with Taurine

1978 • 140 citations

REVERSAL OF ETHANOL-INDUCED HEPATIC STEATOSIS AND LIPID PEROXIDATION BY TAURINE: A STUDY IN RATS

1999 • 80 citations

Relationship between mRNA Levels Quantified by Reverse Transcription-Competitive PCR and Metabolic Activity of CYP3A4 and CYP2E1 in Human Liver

1999 • 79 citations

The Protective Effect of Taurine on the Biomembrane against Damage Produced by Oxygen Radicals.

1993 • 74 citations

Deficiencies of essential and conditionally essential nutrients

1982 • 66 citations

Nutritional Taurine and Central Nervous System Developmenta

1986 • 65 citations

Influence of hepatic taurine concentration on bile acid conjugation with taurine.

1977 • 59 citations

Quantitative Analysis of Constitutive and Inducible CYPs mRNA Expression in the HepG2 Cell Line Using Reverse Transcription-Competitive PCR

2000 • 59 citations

In vitro inhibition of midazolam and quinidine metabolism by flavonoids

1995 • 51 citations

Taurine Down‐Regulates Basal and Osmolarity‐Induced Gene Expression of Its Transporter, but Not the Gene Expression of Its Biosynthetic Enzymes, in Astrocyte Primary Cultures

2000 • 37 citations

On the role of taurine in the cerebellar cortex: a reappraisal.

1985 • 16 citations

Dietary taurine potentiates polychlorinated biphenyl-induced hypercholesterolemia in rats☆

2001 • 15 citations

Taurine modulates expression of transporters in rat brain and heart

1999 • 10 citations

Evidence that taurine modulates osmoregulation by modification of osmolarity sensor protein ENVZ ? expression

1999 • 10 citations

Taurine for treatment of congestive heart failure in humans.

1983 • 8 citations

Effects of taurine and ursodeoxycholic acid on liver function tests in patients with cystic fibrosis.

1990 • 7 citations

[Therapeutic effects of taurine in epilepsy: a clinical and polyphysiographic study (author's transl)].

1975 • 6 citations