Quantitative Analysis of Constitutive and Inducible CYPs mRNA Expression in the HepG2 Cell Line Using Reverse Transcription-Competitive PCR

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

1997 • 755 citations

Enzyme induction in the cytochrome P-450 system

1990 • 631 citations

Clinical Pharmacokinetics of Rifampicin

1978 • 397 citations

Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.

1984 • 246 citations

[42] Use of human hepatocytes to study P450 gene induction

1996 • 171 citations

Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction

1997 • 146 citations

Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor

1992 • 128 citations

Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.

1995 • 93 citations

Relationship between mRNA Levels Quantified by Reverse Transcription-Competitive PCR and Metabolic Activity of CYP3A4 and CYP2E1 in Human Liver

1999 • 79 citations

Use of single sample clearance estimates of cytochrome P450 substrates to characterize human hepatic CYP statusin vivo

1993 • 50 citations

Quantification of Multiple Human Cytochrome P450 mRNA Molecules Using Competitive Reverse Transcriptase-PCR

1998 • 45 citations

Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.

1991 • 43 citations

3-Methylcholanthrene-Mediated Induction of Cytochrome P4501A2 in Human Hepatoma HepG2 Cells as Quantified by the Reverse Transcription-Polymerase Chain Reaction

1994 • 34 citations

Interactions and Drug-Metabolizing Enzymes

1995 • 23 citations

3-Methylcholanthrene and pyridine effects on CYP1A1 and CYP1A2 expression in rat renal tissue.

1995 • 19 citations

Evaluation of Induction of CYP3A mRNA Using the HepG2 Cell Line and Reverse Transcription-PCR.

1999 • 15 citations

Tissue Distribution of ¹⁴C‐Rifampicin II. Accumulation in Melanin‐containing Structures

1975 • 7 citations