EVIDENCE PERTAINING TO AN ENDOGENOUS MECHANISM OF PAIN INHIBITION IN THE CENTRAL NERVOUS SYSTEM

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain

1974 • 1,097 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

The Metabolism of Fatty Acids in the Rat VI. Arachidonic Acid

1965 • 866 citations

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

1973 • 811 citations

Analgesia from Electrical Stimulation in the Brainstem of the Rat

1971 • 751 citations

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

1974 • 707 citations

SOME NEUROLOGICAL SPECIES DIFFERENCES ‐ A POSTERIORI*

1969 • 484 citations

Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioral observations and inhibitory effects on spinal cord interneurons

1973 • 425 citations

Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat

1974 • 417 citations

The Distribution of Adrenergic Nerve Fibres to the Blood Vessels in Skeletal Muscle

1965 • 412 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Morphine analgesia: Blockade by raphe magnus lesions

1975 • 353 citations

Monoaminergic mechanisms of stimulation-produced analgesia

1975 • 345 citations

Sites of morphine induced analgesia in the primate brain: relation to pain pathways

1974 • 332 citations

TERMINATION OF THE CENTRAL PAIN PATHWAY IN MAN: THE CONSCIOUS APPRECIATION OF PAIN

1957 • 315 citations

The adrenergic innervation of the rat thalamus as revealed by the glyoxylic acid fluorescence method

1974 • 312 citations

Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat

1975 • 307 citations

Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor

1968 • 301 citations

Facilitation de r�actions nociceptives par la naloxone chez la souris et chez le rat

1974 • 295 citations

Isolation

1975 • 286 citations

Morphine-like ligand for opiate receptors in human CSF

1975 • 281 citations

Paradoxical Effects after Microinjection of Morphine in the Periaqueductal Gray Matter in the Rat

1974 • 268 citations

Central pathways responsible for depolarization of primary afferent fibres

1962 • 254 citations

Stimulation-produced Analgesia: Development of Tolerance and Cross-Tolerance to Morphine

1975 • 250 citations

Mesencephalic central gray lesions and fear-motivated behavior in rats

1970 • 241 citations

Purification and properties of enkephalin — The possible endogenous ligand for the morphine receptor

1975 • 240 citations

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

1974 • 205 citations

Depressive effects of morphine upon lamina V cells activities in the dorsal horn of the spinal cat

1975 • 198 citations

Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat

1974 • 157 citations

Lamina-specific Suppression of Dorsal-horn Unit Activity by Morphine Sulfate

1974 • 150 citations

Inhibition of the jaw opening reflex by electrical stimulation of the periaqueductal gray matter in the awake, unrestrained cat

1974 • 130 citations

Effects on self-stimulation behavior of drugs influencing dopaminergic neurotransmission mechanisms

1973 • 118 citations

The analgesic effect of electrical stimulation of the diencephalon and mesencephalon

1973 • 112 citations

Somatosensory evoked responses in the mesencephalic central gray matter of the rat

1971 • 90 citations

Partial Purification of an Opiate Receptor from Mouse Brain

1974 • 89 citations

Neural Pathways Associated with Hypothalamically Elicited Attack Behavior in Cats

1971 • 88 citations

Ascending catecholamine systems and morphine analgesia

1975 • 83 citations

Alpha adrenergic blocking agents: anti-nociceptive activity and enhancement of morphine-induced analgesia.

1974 • 73 citations

Analgesia produced by brain stimulation: Evidence of a prolonged onset period

1974 • 72 citations

Role of midbrain central gray in pain-induced defensive boxing of rats

1974 • 69 citations

Self-stimulation loci in the midbrain central gray matter of the rat

1973 • 67 citations

Motivational effects of electrical stimulation in dorsal tegmentum of the rat

1971 • 64 citations

Influence of 6-hydroxydopamine on the effect of morphine on the tail-flick latency

1973 • 57 citations

An Inquiry into the Neurophysiological Basis for Pain

1969 • 57 citations

Substance grise centrale du mésencéphale et comportement d'agression interspécifique du rat

1972 • 56 citations

Regional sensitivity of the rat brain to the inhibitory effects of morphine on wet shake behavior.

1975 • 48 citations

Spinal interneurones involved in presynaptic controls of supraspinal origin†

1973 • 30 citations