Role of the Cytosolic Phospholipase A2-linked Cascade in Signaling by an Oncogenic, Constitutively Active Ha-Ras Isoform

ras GENES

1987 • 3,818 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Calcium-mediated Translocation of Cytosolic Phospholipase A2 to the Nuclear Envelope and Endoplasmic Reticulum

1995 • 469 citations

p38 Mitogen-activated Protein Kinase Phosphorylates Cytosolic Phospholipase A2 (cPLA2) in Thrombin-stimulated Platelets

1996 • 466 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Journey to the surface of the cell: Fos regulation and the SRE.

1995 • 376 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

Tumor Necrosis Factor-α Generates Reactive Oxygen Species via a Cytosolic Phospholipase A2-linked Cascade

2000 • 238 citations

Cytosolic Phospholipase A2 Is Required for Macrophage Arachidonic Acid Release by Agonists That Do and Do Not Mobilize Calcium

2000 • 224 citations

Mitogen-activated Protein (MAP) Kinase Regulates Production of Tumor Necrosis Factor-α and Release of Arachidonic Acid in Mast Cells

1997 • 215 citations

Rac mediates growth factor-induced arachidonic acid release

1995 • 207 citations

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

1997 • 199 citations

Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer

1997 • 170 citations

Phosphorylation and Activation of Cytosolic Phospholipase A₂ by 38‐kDa Mitogen‐Activated Protein Kinase in Collagen‐Stimulated Human Platelets

1997 • 146 citations

Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor.

1994 • 142 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

ras-induced c-fos expression and proliferation in living rat fibroblasts involves C-kinase activation and the serum response element pathway.

1990 • 88 citations

Phosphorylation of Cytosolic Phospholipase A2 and the Release of Arachidonic Acid in Human Neutrophils

1999 • 80 citations

Differential effects of annexins I, II, III, and V on cytosolic phospholipase A2 activity: specific interaction model

2001 • 57 citations

Involvement of cytosolic phospholipase A2, and the subsequent release of arachidonic acid, in signalling by Rac for the generation of intracellular reactive oxygen species in Rat-2 fibroblasts

2000 • 54 citations

Elk-1 Can Recruit SRF to Form a Ternary Complex Upon the Serum Response Element

1996 • 53 citations

Suppression of Ras transformation by serum response factor.

1994 • 44 citations

Nuclear signalling by Rac GTPase: essential role of phospholipase A2

1997 • 34 citations

RAS is required for epidermal growth factor-stimulated arachidonic acid release in rat-1 fibroblasts.

1993 • 28 citations

Annexin‐I inhibits PMA‐induced c‐fos SRE activation by suppressing cytosolic phospholipase A2 signal

2000 • 24 citations

Exogenous C2-ceramide activates c-fos serum response element via Rac-dependent signalling pathway

1998 • 23 citations

Role of Rac GTPase in the nuclear signaling by EGF

1997 • 22 citations

Role of Cytosolic Phospholipase A2 as a Downstream Mediator of Rac in the Signaling Pathway to JNK Stimulation

2000 • 20 citations

Essential role of Rac GTPase in hydrogen peroxide‐induced activation of c‐fos serum response element

1997 • 20 citations

Regulation of smooth muscle alpha-actin promoter in ras-transformed cells: usefulness for setting up reporter gene-based assay system for drug screening.

1992 • 16 citations