A cosmid contig and high resolution restriction map of the 2 megabase region containing the Huntington's disease gene

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Genomic sequencing.

1984 • 8,343 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

1993 • 3,080 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Toward a physical map of the genome of the nematode Caenorhabditis elegans

1986 • 631 citations

Huntingtons Disease

1986 • 551 citations

Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.

1991 • 425 citations

Use of restriction enzymes to detect potential gene sequences in mammalian DNA

1987 • 387 citations

The highest gene concentrations in the human genome are in telomeric bands of metaphase chromosomes.

1992 • 342 citations

Removal of repeated sequences from hybridisation probes

1985 • 293 citations

Direct selection: a method for the isolation of cDNAs encoded by large genomic regions.

1991 • 271 citations

High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe

1993 • 235 citations

High efficiency vectors for cosmid microcloning and genomic analysis

1989 • 190 citations

A positive selection vector for cloning high molecular weight DNA by the bacteriophage P1 system: improved cloning efficacy.

1992 • 160 citations

Construction, arraying, and high-density screening of large insert libraries of human chromosomes X and 21: their potential use as reference libraries.

1991 • 160 citations

The Huntington's disease candidate region exhibits many different haplotypes

1992 • 157 citations

Localization of the huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere

1987 • 126 citations

A strategy for the selection of transcribed sequences in the Xq28 region

1992 • 121 citations

A DNA Segment Encoding Two Genes Very Tightly Linked to Huntington's Disease

1987 • 108 citations

Analysis of cosmids using linearization by phage lambda terminase

1985 • 105 citations

A novel G protein-coupled receptor kinase gene cloned from 4p16.3

1992 • 99 citations

Recombination events suggest potential sites for the Huntington's disease gene

1989 • 92 citations

Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus.

1988 • 92 citations

Magnetic bead capture of expressed sequences encoded within large genomic segments

1993 • 90 citations

Molecular definition of the smallest region of deletion overlap in the Wolf-Hirschhorn syndrome.

1992 • 86 citations

Physical maps of 4p16.3, the area expected to contain the Huntington disease mutation

1990 • 82 citations

Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

1989 • 78 citations

Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

1989 • 77 citations

Algorithms and software tools for ordering clone libraries: application to the mapping of the genome ofSchizosaccharomyces pombe

1993 • 75 citations

Complex patterns of linkage disequilibrium in the Huntington disease region.

1991 • 72 citations

Defined physical limits of the Huntington disease gene candidate region.

1991 • 71 citations

Use of high coverage reference libraries of Drosophila melanogaster for relational data analysis

1991 • 68 citations

Characterization of a yeast artificial chromosome contig spanning the Huntington's disease gene candidate region

1992 • 63 citations

A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene.

1990 • 62 citations

Huntington disease: No evidence for locus heterogeneity

1989 • 54 citations

Increased recombination adjacent to the Huntington disease-linked D4S10 marker

1991 • 51 citations

Mapping of cosmid clones in Huntington's disease region of chromosome 4

1991 • 46 citations

Cloning of the α–adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification

1992 • 38 citations

Chromosome jumping from D4S10 (G8) toward the Huntington disease gene.

1988 • 37 citations

Generation of a 50,000-member human DNA library with an average DNA insert size of 75-100 kbp in a bacteriophage P1 cloning vector.

1990 • 36 citations

The direct screening of cosmid libraries with YAC clones

1991 • 34 citations

The telomeric 60 kb of chromosome arm 4p is homologous to telomeric regions on 13p, 15p, 21p, and 22p

1992 • 34 citations

Nonrandom association between huntington disease and two loci separated by about 3 Mb on 4p16.3

1992 • 28 citations

A computer program package for restriction map analysis and manipulation

1986 • 26 citations

New DNA markers in the Huntington's disease gene candidate region

1991 • 26 citations

Linkage disequilibrium and modification of risk for Huntington disease.

1991 • 20 citations

A recombination event that redefines the Huntington disease region.

1992 • 19 citations

Identification of genes using oligonucleotides corresponding to splice site consensus sequences

1992 • 15 citations

Recombination of 4p16 DNA markers in an unusual family with Huntington disease.

1992 • 15 citations

Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.

1991 • 14 citations

Association of a mature B cell leukemia with a 4p+ chromosomal abnormality: derivation and characterization of a cell line.

1989 • 5 citations