Recombination of 4p16 DNA markers in an unusual family with Huntington disease.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Spontaneous mutation rates to new length alleles at tandem-repetitive hypervariable loci in human DNA

1988 • 773 citations

A Sequence in M13 Phage Detects Hypervariable Minisatellites in Human and Animal DNA

1987 • 575 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

A highly polymorphic locus very tightly linked to the Huntington's disease gene

1988 • 149 citations

Localization of the huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere

1987 • 126 citations

Segregation of the Huntington disease region of human chromosome 4 in a somatic cell hybrid

1989 • 100 citations

Analysis of somatic mutations at human minisatellite loci in tumors and cell lines

1989 • 98 citations

Characterization of eight VNTR loci by agarose gel electrophoresis

1989 • 93 citations

Recombination events suggest potential sites for the Huntington's disease gene

1989 • 92 citations

Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus.

1988 • 92 citations

Physical maps of 4p16.3, the area expected to contain the Huntington disease mutation

1990 • 82 citations

Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

1989 • 78 citations

Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

1989 • 77 citations

Complex patterns of linkage disequilibrium in the Huntington disease region.

1991 • 72 citations

Defined physical limits of the Huntington disease gene candidate region.

1991 • 71 citations

A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene.

1990 • 62 citations

A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates.

1991 • 60 citations

Huntington disease: No evidence for locus heterogeneity

1989 • 54 citations

X-linked severe combined immunodeficiency: localization within the region Xq13.1-q21.1 by linkage and deletion analysis.

1989 • 51 citations

Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90.

1989 • 46 citations

Mapping of cosmid clones in Huntington's disease region of chromosome 4

1991 • 46 citations

Mapping ofD4S98/S114/S113confines the Huntington's defect to a reduced physical region at the telomere of chromosome 4

1988 • 45 citations

Isolation and field-inversion gel electrophoresis analysis of DNA markers located close to the Huntington disease gene

1989 • 44 citations

The mutation rate to Huntington's chorea

1982 • 43 citations

A cloned DNA segment from the telomeric region of human chromosome 4p is not detectably rearranged in Huntington disease patients.

1990 • 24 citations

Characterization and rapid analysis of the highly polymorphic VNTR locus D4S125 (YNZ32), closely linked to the huntington disease gene

1991 • 23 citations

Dinucleotide repeat polymorphism located at D21S120

1990 • 23 citations

A DNA probe, D5 [D4S90] mapping to human chromosome 4p16.3

1988 • 22 citations

Linkage disequilibrium and modification of risk for Huntington disease.

1991 • 20 citations

Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.

1991 • 14 citations

Dinucleotide repeat polymorphism located at D4S169

1991 • 2 citations