Defined physical limits of the Huntington disease gene candidate region.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

Update on Key Emerging Challenges in Cystic Fibrosis

2014 • 3,606 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Separation of Large DNA Molecules by Contour-Clamped Homogeneous Electric Fields

1986 • 1,525 citations

Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors

1987 • 1,517 citations

Huntingtons Disease

1986 • 551 citations

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

1987 • 339 citations

Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

1990 • 187 citations

A highly polymorphic locus very tightly linked to the Huntington's disease gene

1988 • 149 citations

Localization of the huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere

1987 • 126 citations

A DNA Segment Encoding Two Genes Very Tightly Linked to Huntington's Disease

1987 • 108 citations

Recombination events suggest potential sites for the Huntington's disease gene

1989 • 92 citations

Isolation of DNA markers in the direction of the Huntington disease gene from the G8 locus.

1988 • 92 citations

Physical maps of 4p16.3, the area expected to contain the Huntington disease mutation

1990 • 82 citations

Linkage disequilibrium in Huntington's disease: an improved localisation for the gene.

1989 • 78 citations

Non-random association between alleles detected at D4S95 and D4S98 and the Huntington's disease gene.

1989 • 77 citations

Construction of aNotI linking library and isolation of new markers close to the Huntington's disease gene

1988 • 75 citations

A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene

1987 • 64 citations

A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene.

1990 • 62 citations

Huntington disease: No evidence for locus heterogeneity

1989 • 54 citations

Clustering of multiallele DNA markers near the Huntington's disease gene.

1989 • 53 citations

Increased recombination adjacent to the Huntington disease-linked D4S10 marker

1991 • 51 citations

Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90.

1989 • 46 citations

Mapping ofD4S98/S114/S113confines the Huntington's defect to a reduced physical region at the telomere of chromosome 4

1988 • 45 citations

Chromosome jumping from D4S10 (G8) toward the Huntington disease gene.

1988 • 37 citations

A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene

1989 • 32 citations

Isolation and mapping of a polymorphic DNA sequence (pYNZ32) on chromosome 4p [D4S125]

1988 • 30 citations

A cloned DNA segment from the telomeric region of human chromosome 4p is not detectably rearranged in Huntington disease patients.

1990 • 24 citations

Mapping of recombinants near the Huntington disease locus by using G8 (D4S10) and newly isolated markers in the D4S10 region.

1989 • 20 citations