Cytokines in autoimmunity

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis

1994 • 632 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Localization of Tumor Necrosis Factor α in Synovial Tissues and at the Cartilage–Pannus Junction in Patients With Rheumatoid Arthritis

1991 • 585 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.

1994 • 543 citations

Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

1994 • 531 citations

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.

1995 • 487 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

1995 • 407 citations

Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

1991 • 400 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

Decrease in cellularity and expression of adhesion molecules by anti–tumor necrosis factor α monoclonal antibody treatment in patients with rheumatoid arthritis

1996 • 377 citations

Anticytokine treatment of established type II collagen–induced arthritis in DBA/1 mice: A comparative study using anti‐TNFα, anti–IL‐1α/β, and IL‐1Ra

1996 • 370 citations

Involvement of endogenous tumor necrosis factor alpha and transforming growth factor beta during induction of collagen type II arthritis in mice.

1992 • 363 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 • 345 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

In vivo production of interleukin‐10 by non–t cells in rheumatoid arthritis, sjöugren's syndrome, and systemic lupus erythematosus.

1994 • 317 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10: Interferon-γ–secreting cells in the peripheral blood

1996 • 292 citations

Expression of granulocyte‐macrophage colony‐stimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor‐α

1991 • 290 citations

Soluble cytokine receptors: their role in immunoregulation

1991 • 289 citations

The role of IL-12 in the induction of organ-specific autoimmune diseases

1995 • 277 citations

Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis.

1995 • 269 citations

Interleukin‐10 inhibition of the progression of established collagen‐induced arthritis

1996 • 261 citations

Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis

1996 • 255 citations

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.

1994 • 253 citations

"The good, the bad, and the ugly." The role of chemokines in models of human disease.

1996 • 250 citations

Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat.

1996 • 244 citations

Elevated interleukin-10 levels in patients with rheumatoid arthritis

1995 • 243 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Deactivation of vascular endothelium by monoclonal anti–tumor necrosis factor α antibody in rheumatoid arthritis

1996 • 239 citations

IL-12: a key cytokine in immune regulation

1996 • 236 citations

THE THERAPEUTIC EFFECTS OF AN ENGINEERED HUMAN ANTI-TUMOUR NECROSIS FACTOR ALPHA ANTIBODY (CDP571) IN RHEUMATOID ARTHRITIS

1995 • 234 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals.

1991 • 226 citations

Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α

1992 • 216 citations

Synovial interleukin‐1 receptor antagonist and interleukin‐1 balance in rheumatoid arthritis

1994 • 214 citations

Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha.

1991 • 204 citations

Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice.

1995 • 198 citations

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia.

1991 • 198 citations

LOCALIZATION OF INTERLEUKIN-1α, TYPE 1 INTERLEUKIN-1 RECEPTOR AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE SYNOVIAL MEMBRANE AND CARTILAGE/PANNUS JUNCTION IN RHEUMATOID ARTHRITIS

1992 • 187 citations

Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans.

1993 • 183 citations

Monoclonal anti‐TNFα Antibody as a Probe of Pathogenesis and Therapy of Rheumatoid Disease

1995 • 182 citations

Aberrant Expression of HLA-DR Antigens by Insulin-Containing β-Cells in Recent-Onset Type I Diabetes MelIitus

1986 • 180 citations

Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor.

1995 • 178 citations

Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin‐10 and interleukin‐4

1996 • 174 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β

1991 • 167 citations

Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis.

1989 • 166 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice

1995 • 159 citations

The role of chemokines in inflammatory joint disease

1996 • 148 citations

IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium.

1992 • 124 citations

Transmembrane TNF is sufficient to induce localized tissue toxicity and chronic inflammatory arthritis in transgenic mice.

1996 • 121 citations

Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.

1996 • 121 citations

INTERLEUKIN-1β CONVERTING ENZYME INHIBITION BLOCKS PROGRESSION OF TYPE II COLLAGEN-INDUCED ARTHRITIS IN MICE

1996 • 112 citations

Staphylococcal enterotoxin B and tumor‐necrosis factor‐α‐induced relapses of experimental allergic encephalomyelitis: Protection by transforming growth factor‐β and interleukin‐10

1995 • 108 citations

Recombinant human interleukin‐1 receptor type I in the treatment of patients with active rheumatoid arthritis

1996 • 107 citations

Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.

1996 • 105 citations

Engagement of major histocompatibility complex class II molecules by superantigen induces inflammatory cytokine gene expression in human rheumatoid fibroblast-like synoviocytes.

1992 • 103 citations

Interferon effects on interleukin-10 secretion Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients

1995 • 103 citations

GMP‐140 (P‐selectin/CD62) binds to chronically stimulated but not resting CD4⁺ T lymphocytes and regulates their production of proinflammatory cytokines

1992 • 93 citations

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

1992 • 93 citations

Transforming growth factor-β1 in rheumatoid synovial membrane and cartilage pannus junction

1991 • 93 citations

Multiple sclerosis: TNF revisited, with promise

1995 • 88 citations

Cytokine Assays: Role in Evaluation of the Pathogenesis of Autoimmunity

1991 • 83 citations

Cytokines in sera from insulin-dependent diabetic patients at diagnosis

1991 • 78 citations

CIRCULATING SERUM LEVELS OF IL-1ra IN PATIENTS WITH RELAPSING REMITTING MULTIPLE SCLEROSIS ARE NORMAL DURING REMISSION PHASES BUT SIGNIFICANTLY INCREASED EITHER DURING EXACERBATIONS OR IN RESPONSE TO IFN-β TREATMENT

1996 • 76 citations

Curative and protective effects of IL-10 in experimental autoimmune thyroiditis (EAT). Evidence for IL-10-enhanced cell death in EAT.

1995 • 75 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis

1992 • 70 citations

Differential effects of interleukins 10 and 4 on the production of interleukin‐6 by blood and synovium monocytes in rheumatoid arthritis

1995 • 59 citations

Interleukin-12 gene expression is associated with rapid development of diabetes mellitus in non-obese diabetic mice

1996 • 58 citations

High doses of interleukin‐12 inhibit the development of joint disease in DBA/1 mice immunized with type II collagen in complete Freund's adjuvant

1996 • 56 citations

Lymphocyte homing to sites of inflammation

1992 • 55 citations

TNF Inhibitors are Produced Spontaneously by Rheumatoid and Osteoarthritic Synovial Joint Cell Cultures: Evidence of Feedback Control of TNF Action

1995 • 52 citations

Terminal differentiation of spontaneous rheumatoid factor–secreting B cells from rheumatoid arthritis patients depends on endogenous interleukin‐1 0

1995 • 43 citations

Interleukin 2 receptor targeted fusion toxin (DAB₄₈₆‐IL‐2) treatment blocks diabetogenic autoimmunity in non‐obese diabetic mice

1992 • 41 citations

Interleukin-1 enhances the development of type II collagen-induced arthritis only in susceptible and not in resistant mice

1992 • 33 citations

Flare-up of experimental arthritis in mice with murine recombinant IL-1

1992 • 32 citations

Inhibitors of interleukin 1 activity in synovial fluids and in cultured synovial fluid mononuclear cells.

1992 • 32 citations

Granulocyte–macrophage colony‐stimulating factor augments neutrophil‐mediated cartilage degradation and neutrophil adherence

1991 • 31 citations

Increased in vivo production of tumor necrosis factor after development of diabetes in nontreated, long-term diabetic BB rats

1992 • 30 citations

Role of tumor necrosis factor‐α in the regulation of activated synovial T cell growth: Downregulation of synovial T cells in rheumatoid arthritis patients

1995 • 10 citations