Drug hypersensitivity in HIV

Association between presence of HLA-B*5701, HLA-DR7 , and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

2002 • 1,355 citations

Adverse effects of antiretroviral therapy

2000 • 1,062 citations

Treatment for Adult HIV Infection

2006 • 1,052 citations

Pneumocystis carinii Pneumonia: A Comparison Between Patients with the Acquired Immunodeficiency Syndrome and Patients with Other Immunodeficiencies

1984 • 853 citations

Incidence of Serious Side Effects from First-Line Antituberculosis Drugs among Patients Treated for Active Tuberculosis

2003 • 816 citations

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

2002 • 804 citations

HIV Drug Resistance

2004 • 764 citations

Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

1984 • 702 citations

Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials

2007 • 486 citations

Cutaneous Disease and Drug Reactions in HIV Infection

1993 • 485 citations

Predisposition to abacavir hypersensitivity conferred byHLA-B*5701and a haplotypicHsp70-Homvariant

2004 • 446 citations

Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir

2001 • 408 citations

Differences in Metabolism of Sulfonamides Predisposing to Idiosyncratic Toxicity

1986 • 375 citations

Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts

2004 • 318 citations

Prospective Genetic Screening Decreases the Incidence of Abacavir Hypersensitivity Reactions in the Western Australian HIV Cohort Study

2006 • 298 citations

Efavirenz

1998 • 271 citations

Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations

2004 • 258 citations

A Comprehensive Hepatic Safety Analysis of Nevirapine in Different Populations of HIV Infected Patients*

2003 • 240 citations

Abacavir versus Zidovudine Combined with Lamivudine and Efavirenz, for the Treatment of Antiretroviral‐Naive HIV‐Infected Adults

2004 • 228 citations

Three- vs Four-Drug Antiretroviral Regimens for the Initial Treatment of HIV-1 Infection<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2006 • 220 citations

COMPLICATIONS OF CO-TRIMOXAZOLE IN TREATMENT OF AIDS-ASSOCIATED PNEUMOCYSTIS CARINII PNEUMONIA IN HOMOSEXUAL MEN

1983 • 216 citations

Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection

1998 • 206 citations

Clinical and immunogenetic correlates of abacavir hypersensitivity

2005 • 198 citations

Cutaneous hypersensitivity reactions due to thiacetazone in HIV-1 seropositive patients treated for tuberculosis

1991 • 193 citations

Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis carinii Pneumonia

1980 • 177 citations

N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.

1995 • 157 citations

HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients

2006 • 154 citations

Prospective Screening for Human Leukocyte Antigen-B*5701 Avoids Abacavir Hypersensitivity Reaction in the Ethnically Mixed French HIV Population

2007 • 148 citations

Altered patterns of drug metabolism in patients with acquired immunodeficiency syndrome

1993 • 136 citations

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

1999 • 131 citations

Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

2002 • 130 citations

Serious Adverse Cutaneous and Hepatic Toxicities Associated With Nevirapine Use by Non???HIV-Infected Individuals

2004 • 127 citations

The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes

2002 • 121 citations

Sulfamethoxazole and Its Metabolite Nitroso Sulfamethoxazole Stimulate Dendritic Cell Costimulatory Signaling

2007 • 121 citations

Trimethoprim‐Sulfamethoxazole (TMP‐SMZ) Dose Escalation versus Direct Rechallenge forPneumocystis CariniiPneumonia Prophylaxis in Human Immunodeficiency Virus–Infected Patients with Previous Adverse Reaction to TMP‐SMZ

2001 • 107 citations

Prevention of nevirapine-associated exanthema using slow dose escalation and/or corticosteroids

2000 • 81 citations

Incidence and risk factors for rash in Thai patients randomized to regimens with nevirapine, efavirenz or both drugs

2005 • 77 citations

HLA‐B*5701 typing by sequence‐specific amplification: validation and comparison with sequence‐based typing

2005 • 75 citations

Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patients

1997 • 73 citations

Fosamprenavir

2004 • 66 citations

Slow acetylator phenotype and genotype in HIV‐positive patients with sulphamethoxazole hypersensitivity

2003 • 62 citations

Plasma Cysteine Deficiency and Decreased Reduction of Nitrososulfamethoxazole with HIV Infection

2000 • 62 citations

Evidence of an Immune-Mediated Mechanism for an Idiosyncratic Nevirapine-Induced Reaction in the Female Brown Norway Rat

2005 • 62 citations

A Randomized Trial of N-Acetylcysteine for Prevention of Trimethoprim-Sulfamethoxazole Hypersensitivity Reactions in Pneumocystis carinii Pneumonia Prophylaxis (CTN 057)

1998 • 54 citations

Frequency of Cutaneous Reactions on Rechallenge with Nevirapine and Delavirdine

2000 • 51 citations

A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome

2006 • 48 citations

N-acetylcysteine treatment and the risk of toxic reactions to trimethoprim-sulphamethoxazole in primary Pneumocystis carinii prophylaxis in HIV-infected patients

1997 • 44 citations

Cutaneous injection site reactions to long-term therapy with enfuvirtide

2004 • 40 citations

Cross‐Reactivity in HIV‐infected Patients Switched from Trimethoprim‐Sulfamethoxazole to Dapsone

1998 • 40 citations

Incidence and risk factors of rash associated with efavirenz in HIV‐infected patients with preceding nevirapine‐associated rash

2006 • 35 citations

Increased Adverse Drug Reactions to Antimicrobials and Anticonvulsants in Patients with HIV Infection

2006 • 33 citations

Hypersensitivity of HIV-1-Infected Cells to Reactive Sulfonamide Metabolites Correlated to Expression of the HIV-1 Viral Protein Tat

2005 • 20 citations

Successful Desensitization to Enfuvirtide after a Hypersensitivity Reaction in an HIV-1-Infected Man

2004 • 16 citations

Drug-Specific T Cells in An HIV-Positive Patient with Nevirapine-Induced Hepatitis

2006 • 15 citations

Pharmacogenetics and clinical characteristics of patch test confirmed patients with Abacavir hypersensitivity

2006 • 6 citations