Adverse effects of antiretroviral therapy

Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial

1999 • 1,679 citations

Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: acohort study

1999 • 1,549 citations

Severe Adverse Cutaneous Reactions to Drugs

1994 • 1,523 citations

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

1998 • 1,109 citations

A Trial Comparing Nucleoside Monotherapy with Combination Therapy in HIV-Infected Adults with CD4 Cell Counts from 200 to 500 per Cubic Millimeter

1996 • 1,045 citations

Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study

1999 • 937 citations

Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy

1999 • 884 citations

Adverse effects of reverse transcriptase inhibitors

1998 • 853 citations

Highly Active Antiretroviral Therapy in a Large Urban Clinic: Risk Factors for Virologic Failure and Adverse Drug Reactions

1999 • 850 citations

Mitochondrial toxicity of antiviral drugs

1995 • 760 citations

Visceral abdominal-fat accumulation associated with use of indinavir

1998 • 717 citations

Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues

1999 • 674 citations

A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome

2000 • 652 citations

A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy

1999 • 607 citations

Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B

1995 • 605 citations

Lactic acidosis in critical illness

1992 • 594 citations

“Buffalo hump” in men with HIV-1 infection

1998 • 581 citations

A Short-Term Study of the Safety, Pharmacokinetics, and Efficacy of Ritonavir, an Inhibitor of HIV-1 Protease

1995 • 569 citations

The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response

1999 • 548 citations

Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients

1998 • 542 citations

Delta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals

1996 • 510 citations

Cutaneous Disease and Drug Reactions in HIV Infection

1993 • 485 citations

A Preliminary Study of Ritonavir, an Inhibitor of HIV-1 Protease, to Treat HIV-1 Infection

1995 • 484 citations

Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease

1998 • 366 citations

The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1

1999 • 345 citations

Reversion of metabolic abnormalities after switching from HIV-1 protease inhibitors to nevirapine

1999 • 336 citations

Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy

1999 • 315 citations

Indinavir-associated lipodystrophy

1998 • 287 citations

Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine

1989 • 270 citations

Corticosteroids Prevent Early Deterioration in Patients with Moderately Severe Pneumocystis carinii Pneumonia and the Acquired Immunodeficiency Syndrome (AIDS)

1990 • 246 citations

Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection

1998 • 206 citations

A pilot study of exercise training to reduce trunk fat in adults with HIV-associated fat redistribution

1999 • 173 citations

Vascular complications associated with use of HIV protease inhibitors

1998 • 168 citations

Peripheral Neuropathy with Nucleoside Antiretrovirals

1998 • 163 citations

Safety of the maternal–infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study

1998 • 163 citations

Fulminant Hepatic Failure Associated with 2′,3′-Dideoxyinosine (ddI)

1991 • 162 citations

Inhibition of Adipocyte Differentiation by HIV Protease Inhibitors

1999 • 161 citations

Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone

1999 • 158 citations

A Preliminary Evaluation of Nelfinavir Mesylate, an Inhibitor of Human Immunodeficiency Virus (HIV)‐1 Protease, to Treat HIV Infection

1998 • 148 citations

A placebo-controlled trial of didanosine plus stavudine, with and without hydroxyurea, for HIV infection

1998 • 142 citations

Insulin Resistance in HIV Protease Inhibitor–Associated Diabetes

1999 • 134 citations

Toxicity of Combined Ganciclovir and Zidovudine for Cytomegalovirus Disease Associated with AIDS

1990 • 127 citations

Clinical and Laboratory Markers of Hypersensitivity to Trimethoprim-Sulfamethoxazole in Patients with Pneumocystis carinii Pneumonia and AIDS

1993 • 126 citations

Zidovudine‐induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage

1994 • 114 citations

The steady-state plasma pharmacokinetics of indinavir alone and in combination with a low dose of ritonavir in twice daily dosing regimens in HIV-1-infected individuals

1999 • 110 citations

Development of Cervical Fat Pads Following Therapy with Human Immunodeficiency Virus Type 1 Protease Inhibitors

1998 • 105 citations

Protective actions of l-carnitine and acetyl-l-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors

1995 • 103 citations

Anti‐Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9‐[2‐(bis‐pivaloyloxymethyl)‐phosphonylmethoxyethyl]adenine) in HIV‐Infected Patients

1997 • 98 citations

Can HIV epidemics among injection drug users be prevented?

1998 • 87 citations

Changes in renal function associated with indinavir

1998 • 84 citations

The Case for More Cautious, Patient-Focused Antiretroviral Therapy

2000 • 71 citations

Phase I study of 2′-3′-dideoxyinosine administered orally twice daily to patients with AIDS or AIDS-related complex and hematologic intolerance to zidovudine

1991 • 65 citations

Stimulation of vitamin A1 acid signaling by the HIV protease inhibitor indinavir

2000 • 65 citations

The treatment of mitochondrial myopathies and encephalomyopathies

1995 • 63 citations

3′-Azidothymidine (Zidovudine) Inhibits Glycosylation and Dramatically Alters Glycosphingolipid Synthesis in Whole Cells at Clinically Relevant Concentrations

1995 • 57 citations

Variation in incidence of indinavir-associated nephrolithiasis among HIV-positive patients

1998 • 56 citations

Ritonavir, Triglycerides, and Pancreatitis

1999 • 54 citations

Hydroxyurea and HIV: 5 years later-from antiviral to immune-modulating effects

1999 • 54 citations

Fasting hyperinsulinemia and increased waist-to-hip ratios in non-wasting individuals with AIDS

1999 • 47 citations

Drug points: Severe ergotism associated with interaction between ritonavir and ergotamine

1999 • 46 citations

Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection

1994 • 43 citations

Rates and Risk Factors for Adverse Events Associated with Didanosine in the Expanded Access Program

1994 • 43 citations

Effects of Hydroxyurea Administration on the Body Weight, Body Composition and Exercise Performance of Patients with Sickle-Cell Anaemia

1997 • 43 citations

Zidovudine toxicity in uninfected healthcare workers

1997 • 35 citations

Pharmacoepidemiology of adverse drug reactions in hospitalized patients with human immunodeficiency virus disease.

1993 • 33 citations

Influence of Environmental Temperature on Incidence of Indinavir‐Related Nephrolithiasis

1999 • 30 citations

Pathogenesis and management of HIV-associated drug hypersensitivity.

1995 • 25 citations

Metabolic, hepatic and muscular changes during zidovudine therapy

1994 • 25 citations

Increased bleeding in HIV‐positive Haemophiliacs treated with antiretroviral protease inhibitors

1998 • 22 citations

A soluble factor produced by macrophages mediates the neurotoxic effects of HIV-1 Tat in vitro

1999 • 22 citations

Gap between biology and reality in AIDS

1998 • 20 citations

Platelet Dysfunction as the Cause of Spontaneous Bleeding in Two Haemophilic Patients Taking HIV Protease Inhibitors

1998 • 13 citations

AIDS clinical review 1995/1996.

1996 • 9 citations

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