In silico biology through “omics”

Metabolite profiling for plant functional genomics

2000 • 2,062 citations

Genome-Wide Location and Function of DNA Binding Proteins

2000 • 1,720 citations

In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data

2001 • 956 citations

The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities

2000 • 872 citations

Reverse engineering gene networks using singular value decomposition and robust regression

2002 • 694 citations

Identifying regulatory networks by combinatorial analysis of promoter elements

2001 • 652 citations

Regulation of Gene Expression in Flux Balance Models of Metabolism

2001 • 423 citations

Systems Properties of the Haemophilus influenzaeRd Metabolic Genotype

1999 • 405 citations

Transcriptional Regulation in Constraints-based Metabolic Models of Escherichia coli

2002 • 339 citations

Flux analysis of underdetermined metabolic networks: the quest for the missing constraints

1997 • 338 citations

Stoichiometric model ofEscherichia coli metabolism: Incorporation of growth-rate dependent biomass composition and mechanistic energy requirements

1997 • 322 citations

Metabolic modeling of microbial strains in silico

2001 • 313 citations

The challenges of in silico biology

2000 • 301 citations

Simple constrained‐optimization view of acetate overflow in E. coli

1990 • 296 citations

Evolutionary Engineering of Industrially Important Microbial Phenotypes

2001 • 283 citations

Metabolic Capabilities of Escherichia coli: I. Synthesis of Biosynthetic Precursors and Cofactors

1993 • 279 citations

RegulonDB (version 3.2): transcriptional regulation and operon organization in Escherichia coli K-12

2001 • 262 citations

Deciphering gene expression regulatory networks

2002 • 187 citations

MPW: the Metabolic Pathways Database

1998 • 123 citations