Combinatorial Synthesis of Small Organic Molecules

Genetic algorithms in search, optimization, and machine learning

1989 • 49,726 citations

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

1991 • 2,692 citations

A new type of synthetic peptide library for identifying ligand-binding activity

1991 • 1,769 citations

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Synthesis and Applications of Small Molecule Libraries

1996 • 1,451 citations

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1991 • 1,319 citations

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis

1992 • 1,190 citations

Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

1994 • 1,130 citations

Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

1994 • 1,126 citations

General method for rapid synthesis of multicomponent peptide mixtures

1991 • 1,122 citations

Multiple-Component Condensation Strategies for Combinatorial Library Synthesis

1996 • 1,083 citations

Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support

1992 • 1,052 citations

A Combinatorial Approach to Materials Discovery

1995 • 1,006 citations

Peptoids: a modular approach to drug discovery.

1992 • 918 citations

Encoded combinatorial chemistry.

1992 • 893 citations

Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.

1987 • 849 citations

p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide Fragments

1973 • 775 citations

New Aspects of the Maillard Reaction in Foods and in the Human Body

1990 • 727 citations

The logic of chemical synthesis

1996 • 682 citations

Combinatorial synthesis — the design of compound libraries and their application to drug discovery

1995 • 655 citations

Organic Chemistry on Solid Supports

1996 • 646 citations

Multicomponent one-pot annulations forming 3 to 6 bonds

1986 • 564 citations

Multicomponent reactions in organic chemistry

1994 • 559 citations

A Class of Cobalt Oxide Magnetoresistance Materials Discovered with Combinatorial Synthesis

1995 • 529 citations

A priori delineation of a peptide which mimics a discontinuous antigenic determinant

1986 • 499 citations

Neighborhood Behavior: A Useful Concept for Validation of “Molecular Diversity” Descriptors

1996 • 485 citations

Solid-phase organic reactions: A review of the recent literature

1996 • 479 citations

Complex synthetic chemical libraries indexed with molecular tags.

1993 • 444 citations

Bromination and lithiation: two important steps in the functionalization of polystyrene resins

1976 • 350 citations

Towards the Chemical Synthesis of Proteins

1991 • 338 citations

"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.

1993 • 337 citations

Generation and screening of an oligonucleotide-encoded synthetic peptide library.

1993 • 331 citations

Discovery of Sequence-Selective Peptide Binding by Synthetic Receptors Using Encoded Combinatorial Libraries

1996 • 305 citations

Measuring Diversity: Experimental Design of Combinatorial Libraries for Drug Discovery

1995 • 299 citations

Combinatorially selected guanosine-quartet structureis a potent inhibitor of human immunodeficiency virus envelope-mediated cellfusion.

1994 • 297 citations

Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.

1985 • 289 citations

Design, Synthesis, and Evaluation of Small-Molecule Libraries

1996 • 286 citations

Multiple Peptide Synthesis Methods and Their Applications. New Synthetic Methods (87)

1992 • 286 citations

Postcondensation Modifications of Ugi Four-Component Condensation Products: 1-Isocyanocyclohexene as a Convertible Isocyanide. Mechanism of Conversion, Synthesis of Diverse Structures, and Demonstration of Resin Capture

1996 • 285 citations

Liquid Phase Synthesis of Peptides

1972 • 282 citations

Radiofrequency Encoded Combinatorial Chemistry

1995 • 275 citations

Discovery of Chiral Catalysts through Ligand Diversity: Ti‐Catalyzed Enantioselective Addition of TMSCN to meso Epoxides

1996 • 271 citations

Strategy and Tactics in Combinatorial Organic Synthesis. Applications to Drug Discovery

1996 • 266 citations

The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.

1994 • 265 citations

Radio Frequency Tag Encoded Combinatorial Library Method for the Discovery of Tripeptide-Substituted Cinnamic Acid Inhibitors of the Protein Tyrosine Phosphatase PTP1B

1995 • 264 citations

Approaches to Combinatorial Synthesis of Heterocycles: A Solid-Phase Synthesis of 1,4-Dihydropyridines

1996 • 251 citations

Activation Method to Prepare a Highly Reactive Acylsulfonamide “Safety-Catch” Linker for Solid-Phase Synthesis¹

1996 • 248 citations

The use of insoluble polymer supports in general organic synthesis

1978 • 246 citations

The safety catch principle in solid phase peptide synthesis

1971 • 245 citations

Tetrahedron report number 103

1981 • 239 citations

Synthetic methods for the implementation of encoded combinatorial chemistry

1993 • 234 citations

A two-step, three-component synthesis of PGE1: utilization of .alpha.-iodo enones in Pd(0)-catalyzed cross-couplings of organoboranes

1993 • 230 citations

Combinatorial Peptide and Nonpeptide Libraries

1996 • 230 citations

A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry

1995 • 229 citations

The Structural Basis of Sequence-Independent Peptide Binding by OppA Protein

1994 • 226 citations

A General Method for Molecular Tagging of Encoded Combinatorial Chemistry Libraries

1994 • 225 citations

Isonitrile, II. Reaktion von Isonitrilen mit Carbonylverbindungen, Aminen und Stickstoffwasserstoffsäure

1961 • 224 citations

Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization / cleavage step

1996 • 213 citations

High-Resolution 1H NMR in Solid-Phase Organic Synthesis

1994 • 213 citations

Reagents for Combinatorial Organic Synthesis: Development of a New o-Nitrobenzyl Photolabile Linker for Solid Phase Synthesis

1995 • 210 citations

Carbon-Carbon Bond-Forming Methods on Solid Support. Utilization of Kenner's "Safety-Catch" Linker

1994 • 207 citations

A Silicon-Based Linker for Traceless Solid-Phase Synthesis

1995 • 205 citations

New Catalysts and Conditions for a CH Insertion Reaction Identified by High Throughput Catalyst Screening

1996 • 202 citations

Optimization of the Biological Activity of Combinatorial Compound Libraries by a Genetic Algorithm

1995 • 197 citations

The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands

1993 • 196 citations

Straightforward and general method for coupling alcohols to solid supports

1994 • 191 citations

Classics in total synthesis : targets, strategies, methods

1996 • 185 citations

A fast procedure for the reduction of azides and nitro compounds based on the reducing ability of Sn(SR)3-species

1990 • 185 citations

Using a Genetic Algorithm To Suggest Combinatorial Libraries

1995 • 178 citations

Peptide synthesis by a combination of solid-phase and solution methods I: A new very acid-labile anchor group for the solid phase synthesis of fully protected fragments

1988 • 177 citations

Biaryl synthesis via suzuki coupling on a solid support

1994 • 175 citations

A Comparison of NMR Spectra Obtained for Solid-Phase-Synthesis Resins Using Conventional High-Resolution, Magic-Angle-Spinning, and High-Resolution Magic-Angle-Spinning Probes

1996 • 174 citations

Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents

1992 • 171 citations

Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings

1994 • 169 citations

Imidazole libraries on solid support

1996 • 168 citations

Encoded combinatorial peptide libraries containing non-natural amino acids

1993 • 165 citations

Solid-Phase Synthesis of Structurally Diverse 1,4-Benzodiazepine Derivatives Using the Stille Coupling Reaction

1995 • 162 citations

Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library

1995 • 161 citations

Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines: Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library

1995 • 161 citations

Solid-Supported Combinatorial Synthesis of Structurally Diverse β-Lactams

1996 • 158 citations

Die Maillard‐Reaktion in Lebensmitteln und im menschlichen Körper – neue Ergebnisse zu Chemie, Biochemie und Medizin

1990 • 158 citations

Liquid-phase combinatorial synthesis.

1995 • 156 citations

CLEAR: A Novel Family of Highly Cross-Linked Polymeric Supports for Solid-Phase Peptide Synthesis^1,2

1996 • 155 citations

Synthesis of Tetrasubstituted Ethylenes on Solid Support via Resin Capture

1996 • 154 citations

Trimethylorthoformate: A mild and effective dehydrating reagent for solution and solid phase imine formation

1995 • 153 citations

Novel Solution Phase Strategy for the Synthesis of Chemical Libraries Containing Small Organic Molecules

1996 • 152 citations

Affinity Capillary Electrophoresis−Mass Spectrometry for Screening Combinatorial Libraries

1996 • 151 citations

Molecular Diversity via a Convertible Isocyanide in the Ugi Four-Component Condensation

1995 • 151 citations

A Mass Spectrometric Solution to the Address Problem of Combinatorial Libraries

1994 • 150 citations

Organische Chemie an fester Phase

1996 • 150 citations

A General Solid-Phase Synthesis Strategy for the Preparation of 2-Pyrrolidinemethanol Ligands

1995 • 149 citations

Synthesis of tetrasubstituted imidazoles via α-(N-acyl-N-alkylamino)-β-ketoamides on Wang resin

1996 • 145 citations

"Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis

1994 • 143 citations

An expedient and high-yielding method for the solid-phase synthesis of diverse 1,4-benzodiazepine-2,5-diones

1995 • 142 citations

Influence of Resin Structure, Tether Length, and Solvent upon the High-Resolution ¹H NMR Spectra of Solid-Phase-Synthesis Resins

1996 • 141 citations

Combinatorial Organic Synthesis Using Parke-Davis's DIVERSOMER Method

1996 • 139 citations

Methods for Combinatorial Organic Synthesis: The Use of Fast 13C NMR Analysis for Gel Phase Reaction Monitoring

1994 • 137 citations

The combinatorial synthesis of chiral phosphine ligands

1996 • 135 citations

Three-dimensional orthogonal protection scheme for solid-phase peptide synthesis under mild conditions

1985 • 134 citations

Screening Derivatized Peptide Libraries for Tight Binding Inhibitors to Carbonic Anhydrase II by Electrospray Ionization-Mass Spectrometry

1996 • 134 citations

Simultaneous Solid-Phase Synthesis of .beta.-Turn Mimetics Incorporating Side-Chain Functionality

1994 • 133 citations

Expedient Method for the Solid-Phase Synthesis of Aspartic Acid Protease Inhibitors Directed toward the Generation of Libraries

1995 • 131 citations

Electrospray Mass Spectrometry and Tandem Mass Spectrometry of Synthetic Multicomponent Peptide Mixtures: Determination of Composition and Purity

1994 • 130 citations

Molecular diversity and combinatorial chemistry : libraries and drug discovery

1996 • 129 citations

Analytical Techniques in Combinatorial Chemistry: MAS CH Correlation in Solvent-Swollen Resin

1995 • 128 citations

Strategies for Combinatorial Organic Synthesis: Solution and Polymer-Supported Synthesis of 4-Thiazolidinones and 4-Metathiazanones Derived from Amino Acids

1995 • 127 citations

The Passerini and Ugi Reactions

1991 • 126 citations

A Structure-Based Library Approach to Kinase Inhibitors

1996 • 125 citations

New promise in combinatorial chemistry: synthesis, characterization, and screening of small-molecule libraries in solution

1995 • 125 citations

An NMR Method To Identify Nondestructively Chemical Compounds Bound to a Single Solid-Phase-Synthesis Bead for Combinatorial Chemistry Applications

1996 • 121 citations

Infrared spectrum of a single resin bead for real-time monitoring of solid-phase reactions

1995 • 119 citations

POEPOP and POEPS: Inert polyethylene glycol crosslinked polymeric supports for solid synthesis

1996 • 117 citations

Protodetachable Arylsilane Polymer Linkages for Use in Solid Phase Organic Synthesis

1995 • 117 citations

A solid phase CBZ chloride equivalent — a new matrix specific linker

1995 • 115 citations

Genetic algorithms in molecular recognition and design

1995 • 112 citations

Solid Phase Chemistry: Direct Monitoring by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry. A Tool for Combinatorial Chemistry

1995 • 110 citations

Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis

1992 • 110 citations

Synthesis of a Small Molecule Combinatorial Library Encoded with Molecular Tags

1995 • 109 citations

Application of Genetic Algorithms to Combinatorial Synthesis: A Computational Approach to Lead Identification and Lead Optimization^,

1996 • 107 citations

Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine Tags

1996 • 107 citations

Generalized Dipeptidomimetic Template: Solution Phase Parallel Synthesis of Combinatorial Libraries

1996 • 106 citations

Tagged versus untagged libraries: methods for the generation and screening of combinatorial chemical libraries.

1994 • 106 citations

Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines

1996 • 104 citations

Solid phase synthesis of aryl ethers via the mitsunobu reaction

1995 • 102 citations

Use of a convertible isocyanide for generation of Ugi reaction derivatives on solid support: Synthesis of α-acylaminoesters and pyrroles

1996 • 101 citations

A novel linker strategy for solid-phase synthesis

1996 • 100 citations

Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.

1993 • 100 citations

Solid-Phase Synthesis of Biaryls via the Stille Reaction

1995 • 100 citations

The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries

1996 • 99 citations

A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries

1996 • 98 citations

From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold

1994 • 98 citations

Preparation and Screening against Acetylcholinesterase of a Non-Peptide "Indexed" Combinatorial Library

1995 • 97 citations

Solid-Phase Suzuki Coupling for C−C Bond Formation

1996 • 95 citations

Multiple simultaneous synthesis of phenolic libraries

1995 • 95 citations

Auf dem Weg zur chemischen Synthese von Proteinen

1991 • 95 citations

Ruthenium‐Catalyzed Metathesis of Polymer‐Bound Olefins

1996 • 94 citations

A single-bead decode strategy using electrospray ionization mass spectrometry and a new photolabile linker: 3-Amino-3-(2-nitrophenyl)propionic acid

1995 • 94 citations

Orthogonal Combinatorial Chemical Libraries

1995 • 94 citations

A general method for the solid phase synthesis of ureas

1994 • 92 citations

Entwicklung von chiralen Katalysatoren durch kombinatorische Ligandenvariation – Ti-katalysierte enantioselektive Addition von TMSCN anmeso-Epoxide

1996 • 92 citations

A paradigm for drug discovery employing encoded combinatorial libraries.

1995 • 92 citations

Methoden der multiplen Peptidsynthese und ihre Anwendungen

1992 • 92 citations

Recursive deconvolution of combinatorial chemical libraries.

1994 • 91 citations

Solid-phase synthesis of defined 1,4-benzodiazepine-2,5-dione mixtures

1995 • 91 citations

Formation of carbon-carbon bond on solid support: Application of the stille reaction

1994 • 90 citations

Heck reactions in solid phase synthesis

1994 • 89 citations

Three-component coupling synthesis of prostaglandins. A simplified, general procedure

1990 • 88 citations

Fischer indole synthesis on a solid support

1996 • 88 citations

Solid-phase synthesis of proline analogs via a three component 1,3-dipolar cycloaddition

1996 • 87 citations

Evaluation of Mass Spectrometric Methods Applicable to the Direct Analysis of Non-Peptide Bead-Bound Combinatorial Libraries

1996 • 87 citations

Formation of CC bond in solid phase synthesis using the heck reaction

1995 • 87 citations

Polymer-supported synthesis of 2,5-disubstituted tetrahydrofurans

1992 • 86 citations

Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy

1994 • 86 citations

Solution and solid phase synthesis of 5-alkoxyhydantoin libraries with a three-fold functional diversity

1996 • 86 citations

Polymer-supported Mitsunobu ether formation and its use in combinatorial chemistry

1995 • 85 citations

Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library

1996 • 84 citations

Chemical synthesis of peptide libraries

1993 • 83 citations

Solid phase synthesis of pyrroles derived from a four component condensation

1996 • 83 citations

Solid phase synthesis of alkenes using the horner-wadsworth-emmons reaction and monitoring by gel phase 31P NMR

1995 • 83 citations

A study and mechanistic interpretation of the electronic and steric effects that determine the stereochemical outcome of the reaction of Schiff bases with homophthalic anhydride and 3-phenylsuccinic anhydride

1987 • 82 citations

Durch Screening ermittelte Katalysatoren und Reaktionsbedingungen für eine C‐H‐Insertionsreaktion

1996 • 79 citations

Solid-Phase Synthesis of Highly Substituted Peptoid 1(2H)-Isoquinolinones

1995 • 79 citations

Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores

1995 • 78 citations

Solid phase synthesis of benzimidazoles

1996 • 78 citations

Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination

1995 • 78 citations

Deconvolution of Combinatorial Libraries for Drug Discovery: A Model System

1995 • 77 citations

Solid-phase synthesis of “small” organic molecules based on thiazolidine scaffold

1995 • 77 citations

Applications of small-molecule combinatorial chemistry to drug discovery

1996 • 75 citations

Solid‐Phase, Parallel Syntheses by Ugi Multicomponent Condensation

1996 • 75 citations

Site-specific isotopic labeling of proteins for NMR studies

1992 • 74 citations

A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: A universal and dipeptide mimetic template

1996 • 73 citations

Deconvolution of Combinatorial Libraries for Drug Discovery: Experimental Comparison of Pooling Strategies

1996 • 72 citations

Assessing Similarity and Diversity of Combinatorial Libraries by Spatial Autocorrelation Functions and Neural Networks

1996 • 72 citations

Direct characterization of solid phase resin-bound molecules by mass spectrometry

1996 • 72 citations

Reversible Covalent Attachment of C60 to a Polymer Support

1994 • 70 citations

Synthesis and biological evaluation of a library containing potentially 1600 amides / esters. A strategy for rapid compound generation and screening.

1994 • 69 citations

An efficient solid phase synthetic route to 1,3-disubstituted 2,4(1H,3H)-Quinazolinediones suitable for combinatorial synthesis

1996 • 67 citations

Palladium-Mediated Macrocyclization on Solid Support and Its Applications to Combinatorial Synthesis

1995 • 67 citations

19F NMR monitoring of a SNAr reaction on solid support

1996 • 67 citations

Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage‐cleavage chemistry

1993 • 67 citations

A polymer-supported C2-symmetric chiral auxiliary: Preparation of non-racemic 3,5-disubstituted-γ-butyrolactones

1994 • 67 citations

Synthesis of ketones and aldehydes via reactions of Weinreb-type amides on solid support

1996 • 67 citations

Parallel-compound synthesis: Methodology for accelerating drug discovery

1996 • 66 citations

Solid-phase photochemical C-S bond cleavage of thioethers-a new approach to the solid-phase production of non-peptide molecules

1994 • 66 citations

A strategy for urea linked diamine libraries

1995 • 66 citations

One-pot palladium-catalyzed synthesis of 2,3-disubstituted bicyclo[2.2.1]heptanes and bicyclo[2.2.1]hept-5-enes

1982 • 66 citations

Solid phase synthesis of 1,2,3,4-tetrahydro-β-carbolines; implications for combinatorial chemistry

1995 • 66 citations

Probing solid-phase reactions by monitoring the IR bands of compounds on a single “flattened” resin bead

1996 • 66 citations

Characterization of the Complexity of Small-Molecule Libraries by Electrospray Ionization Mass Spectrometry

1995 • 65 citations

Aldol reactions on solid phase. Sc(OTf)3-Catalyzed aldol reactions of polymer-supported silyl enol ethers with aldehydes providing convenient methods for the preparation of 1,3-diol, β-hydroxy carboxylic acid, and β-hydroxy aldehyde libraries

1996 • 65 citations

Pictet-Spengler reaction on solid support: Synthesis of 1,2,3,4-tetrahydro-β-carboline libraries

1996 • 64 citations

Solid support synthesis of highly functionalized pyrazoles and isoxazoles; Scaffolds for molecular diversity

1996 • 64 citations

Combinatorial Technologies Involving Reiterative Division/Coupling/Recombination: Statistical Considerations

1994 • 64 citations

Acylation of ester enolates by N-methoxy-N-methylamides: an effective synthesis of .beta.-keto esters

1989 • 64 citations

Palladium-Mediated Three-Component Coupling Strategy for the Solid-Phase Synthesis of Tropane Derivatives¹

1996 • 64 citations

Free Solution Identification of Candidate Peptides from Combinatorial Libraries by Affinity Capillary Electrophoresis/Mass Spectrometry

1995 • 63 citations

Magic angle spinning NMR: A valuable tool for monitoring the progress of reactions in solid phase synthesis

1996 • 62 citations

A surprising observation about Mitsunobu reactions in solid phase synthesis

1994 • 62 citations

Aryl-aryl cross coupling on a solid support using zinc organic reagents and palladium catalysis

1996 • 61 citations

Combinatorial Peptide Libraries: Robotic Synthesis and Analysis by Nuclear Magnetic Resonance, Mass Spectrometry, Tandem Mass Spectrometry, and High-Performance Capillary Electrophoresis Techniques

1996 • 61 citations

Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones

1996 • 61 citations

The use of anion exchange resins for the synthesis of combinatorial libraries containing aryl and heteroaryl ethers

1996 • 60 citations

Application of the Pictet-Spengler reaction in combinatorial chemistry

1996 • 60 citations

Polymer-Supported Synthesis of Cyclic Ethers: Electrophilic Cyclization of Isoxazolines

1995 • 60 citations

Grafted supports used with the multipin method of peptide synthesis

1994 • 59 citations

Radiofrequenz‐verschlüsselte kombinatorische Chemie

1995 • 59 citations

Matrix‐assisted laser desorption ionization for rapid determination of the sequences of biologically active peptides isolated from support‐bound combinatorial peptide libraries

1994 • 59 citations

Pictet-Spengler reaction on solid support

1996 • 58 citations

Solid-phase synthesis of 5,6-dihydropyrimidine-2,4-diones

1996 • 58 citations

Microchemical structural determination of a peptoid covalently bound to a polymeric bead by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

1994 • 58 citations

Ion‐Spray Mass Spectrometry and High‐Performance Liquid Chromatography—Mass Spectrometry of Synthetic Peptide Libraries

1993 • 57 citations

Regioselectivity in cycloaddition reactions on solid phases

1980 • 57 citations

Peptide synthesis on the new polyoxyethylene‐polystyrene graft copolymer, synthesis of insulin B 21–30

1985 • 57 citations

Pauson-Khand cycloadditions of polymer-linked substrates

1990 • 57 citations

Stereoselective Solid‐Phase Synthesis of Cyclopentane and Cyclohexane Derivatives by Two‐Component Domino Reactions: Generation of Combinatorial Libraries

1996 • 57 citations

Combinatorial Libraries

1996 • 57 citations

A General and Expedient Method for the Solid-Phase Synthesis of Structurally Diverse 1-Phenylpyrazolone Derivatives

1996 • 55 citations

Solid Phase Synthesis of Lavendustin A and Analogs

1995 • 55 citations

History of combinatorial chemistry

1995 • 54 citations

New perspectives in lead generation II: Evaluating molecular diversity

1996 • 54 citations

Use of Spin Echo Magic Angle Spinning ¹H NMR in Reaction Monitoring in Combinatorial Organic Synthesis

1996 • 53 citations

Assessing the ability of chemical similarity measures to discriminate between active and inactive compounds

1996 • 51 citations

Optimierung der biologischen Aktivität von kombinatorischen Verbindungsbibliotheken durch einen genetischen Algorithmus

1995 • 50 citations

Solid phase organic synthesis (SPOS): A novel route to diketopiperazines and diketomorpholines

1996 • 50 citations

Synthesis and Photolysis Properties of a Photolabile Linker Based on 3‘-Methoxybenzoin

1996 • 50 citations

Interaction of a Peptidomimetic Aminimide Inhibitor with Elastase

1995 • 49 citations

Linkers for combinatorial chemistry and reaction analysis using solid phase in situ mass spectrometry

1995 • 49 citations

The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317

1995 • 45 citations

The design and synthesis of substituted biphenyl libraries

1996 • 45 citations

Solid-phase synthesis of peptide aminoalkylamides using an allyl linker

1996 • 44 citations

The solid phase synthesis of dihydro- and tetrahydroisoquinolines

1995 • 44 citations

A Direct Method for Reductive Deamination of Aliphatic Amines

1964 • 44 citations

All-cis cyclopentane scaffolding for combinatorial solid phase synthesis of small non-peptide compounds

1994 • 44 citations

Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids

1996 • 44 citations

Synthesis of Nh-acyl-α-aminoamides on rink resin: Inhibitors of the hematopoietic protein tyrosine phosphatase (HePTP)

1995 • 43 citations

Lessons from the Immune System: From Catalysis to Materials Science

1996 • 43 citations

Multipin solid phase synthesis of ethers using modified Mitsunobu chemistry

1996 • 43 citations

Solid phase reductive alkylation of secondary amines

1996 • 43 citations

Molecular Diversity and Libraries of Structures: Synthesis and Screening

1996 • 42 citations

Use of FT-IR Internal Reflection Spectroscopy in Combinatorial Chemistry

1996 • 42 citations

Discovery of a novel tetrahydroacridine acetylcholinesterase inhibitor through an indexed combinatorial library

1995 • 41 citations

Diastereoselective Diels-Alder reactions of nonracemic 3- and 4-amino furans bound to polystyrene. A comparison of these reactions to their solution state analogues

1996 • 41 citations

A combinatorial method for the solid phase synthesis of α-amino phosphonates and phosphonic acids

1996 • 41 citations

Solution-phase synthesis in combinatorial chemistry: Applications in drug discovery

1996 • 40 citations

Solid Phase Synthesis of Aryl and Benzylpiperazines and their Application in Combinatorial Chemistry

1995 • 40 citations

Library generation through successive substitution of trichlorotriazine

1996 • 40 citations

Analytical Techniques for Combinatorial Chemistry: Quantitative Infrared Spectroscopic Measurements of Deuterium-Labeled Protecting Groups

1996 • 40 citations

Symmetrical structure allowing the selective multiple release of a defined quantity of peptide from a single bead of polymeric support

1993 • 40 citations

Palladium- or nickel-catalyzed sequential reaction of organic bromides, bicyclo[2.2.1]hept-2-ene or bicyclo[2.2.1]hepta-2,5-diene and alkynes

1984 • 39 citations

A linker that allows efficient formation of aliphatic CH bonds on polymeric supports

1996 • 38 citations

Asymmetric multipoint control by palladium-catalyzed diastereoselective tandem carbon-carbon bond formation

1992 • 38 citations

Polymer-Supported Synthesis of Cyclic Ethers: Electrophilic Cyclization of Tetrahydrofuroisoxazolines

1995 • 37 citations

Selective cleavage of aryl esters by anhydrous alkali carbonates

1976 • 36 citations

Solid phase synthesis of tetrahydroisoquinolines & tetrahydroimidazopyridines

1996 • 36 citations

Structurally homogeneous and heterogeneous synthetic combinatorial libraries

1996 • 35 citations

Solid phase polyamine linkers-their utility in synthesis and the preparation of directed libraries against trypanothione reductase

1996 • 35 citations

Structurally diverse 2,6-disubstituted quinoline derivatives by solid-phase synthesis

1996 • 34 citations

The synthesis of 2-oxopiperazines by intramolecular Michael addition on solid support

1996 • 34 citations

A solid phase synthesis of miconazole analogs via an iodoetherification reaction

1996 • 32 citations

Combinatorial method for the synthesis of α-hydroxy phosphonates on Wang resin

1996 • 32 citations

Rutheniumkatalysierte Metathese polymergebundener Olefine

1996 • 32 citations

Solid-phase combinatorial chemistry and novel tagging methods for identifying leads

1995 • 32 citations

Discovery of a herbicidal lead using polymer-bound activated esters in generating a combinatorial library of amides and esters

1996 • 32 citations

Libraries of non-polymeric organic molecules

1995 • 32 citations

Beyond peptide and nucleic acid combinatorial libraries-applying unions of multicomponent reactions towards the generation of carbohydrate combinatorial libraries

1995 • 31 citations

Neuartiges Verfahren zur Herstellung von Bibliotheken kleiner organischer Moleküle

1994 • 30 citations

Solid-phase synthesis of substituted 3-aminothiophenes and 2-methylene-2,3-dihydrothiazoles

1996 • 30 citations

A simple multiple release system for combinatorial library and peptide analysis

1996 • 28 citations

DIVERSOMER^TM technology: Solid phase synthesis, automation, and integration for the generation of chemical diversity

1994 • 28 citations

A new linker for primary amines applicable to combinatorial approaches

1996 • 28 citations

Deconvolution of Combinatorial Libraries for Drug Discovery: Theoretical Comparison of Pooling Strategies

1996 • 28 citations

The Challenge of Preparing and Testing Combinatorial Compound Libraries in the Fast Lane, at the Front End of Drug Development

1994 • 27 citations

Automated synthesis and combinatorial chemistry

1995 • 27 citations

Solution-phase generation of tetraurea libraries

1996 • 27 citations

A universal allyl linker for solid-phase synthesis

1996 • 26 citations

Synthese und Halbleitereigenschaften arylsubstituierter Imidazole

1967 • 26 citations

Combinatorial peptide synthesis: statistical evaluation of peptide distribution

1996 • 26 citations

Binary Encoding of Compound Libraries

1994 • 25 citations

Facile synthesis of a o-nitrobenzyl photolabile linker for combinatorial chemistry

1996 • 25 citations

Combinatorial chemistry: Direct analysis of bead surface associated materials

1995 • 23 citations

Ionenspray‐Massenspektrometrie und Hochleistungsflüssigkeitschromatographie ‐ Massenspektrometrie von synthetischen Peptidbibliotheken

1993 • 23 citations

Synthesis and hypocholesterolemic activity of 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-diones, novel inhibitors of acylCoA: cholesterol O-acyltransferase

1991 • 21 citations

The impact of polystyrene resins in solid-phase organic synthesis

1996 • 20 citations

Automating combinatorial chemistry: A primer on benchtop robotic systems

1996 • 20 citations

Stereoselektive Festphasensynthese von Cyclopentanen und Cyclohexanen durch Mehrkomponenten‐Domino‐Reaktion – Aufbau einer Substanzbibliothek durch kombinatorische Chemie

1996 • 20 citations

Sample size determination in combinatorial chemistry.

1995 • 20 citations

Combinatorial synthesis of small-molecule libraries using 3-amino-5-hydroxybenzoic acid

1996 • 19 citations

Computer-based screening of compound databases for the identification of novel leads

1996 • 19 citations

Solid phase synthesis of peptide aminoalkylamides development and application of new linking agents

1987 • 18 citations

Binäre Codierung von Verbindungsbibliotheken

1994 • 16 citations

Bifunctional scaffolds as templates for synthetic combinatorial libraries

1996 • 16 citations

Parallele Festphasensynthesen durch Ugi‐Mehrkomponentenkondensation

1996 • 16 citations

Microchip Encoded Combinatorial Libraries: Generation of a Spatially Encoded Library from a Pool Synthesis The Solid-Phase Synthesis of Complex Small Molecules

1996 • 15 citations

Organopalladium approaches to prostaglandins. 9. Synthesis of a prostaglandin endoperoxide analogue by allylpalladation-ozonolysis of norbornene

1988 • 14 citations

Organopalladium approaches to prostaglandins. 4. Synthesis of the first interphenylene PGH2 analogs via benzylpalladation

1985 • 14 citations

A new combination of protecting groups and links for encoded synthetic libraries suited for consecutive tests on the solid phase and in solution

1996 • 13 citations

Screeningverfahren in Lösung zur Isolierung biologisch aktiver Verbindungen aus einer Molekülbibliothek

1994 • 13 citations

Combinatorial chemistry: A conservative perspective

1995 • 12 citations

Bewertung der Ähnlichkeit und Vielfalt von Verbindungsbibliotheken mit räumlichen Autokorrelationsfunktionen und neuronalen Netzen

1995 • 11 citations

Microautoradiographic identification of receptor-ligand interactions in bead-supported combinatorial libraries

1996 • 11 citations

Methods for building libraries of peptide structures and determination of consensus sequences

1993 • 9 citations

Modification of Substrate Reactivity Using Soluble Polymeric Supports

1995 • 9 citations

MEDIA technique calculates electron densities

1995 • 7 citations

Consideration of Solid-Phase Synthesis with Reference to Quinolone Antibiotics

1996 • 7 citations

The Solid-Phase Part of Supported Small-Molecule Synthesis

1996 • 6 citations

HeartWell ‐ healthy alliances in action

1996 • 4 citations

Oxford Molecular buys chemical software firm

1995 • 3 citations