History of combinatorial chemistry

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

1991 • 2,692 citations

Searching for Peptide Ligands with an Epitope Library

1990 • 2,080 citations

A new type of synthetic peptide library for identifying ligand-binding activity

1991 • 1,769 citations

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1991 • 1,319 citations

General method for rapid synthesis of multicomponent peptide mixtures

1991 • 1,122 citations

Electrophoretic Mobilities of Peptides on Paper and their Use in the Determination of Amide Groups

1966 • 1,006 citations

Peptides on phage: a vast library of peptides for identifying ligands.

1990 • 928 citations

Random Peptide Libraries: a Source of Specific Protein Binding Molecules

1990 • 910 citations

Encoded combinatorial chemistry.

1992 • 893 citations

A priori delineation of a peptide which mimics a discontinuous antigenic determinant

1986 • 499 citations

Complex synthetic chemical libraries indexed with molecular tags.

1993 • 444 citations

Generation and screening of an oligonucleotide-encoded synthetic peptide library.

1993 • 331 citations

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.

1992 • 326 citations

Synthetic methods for the implementation of encoded combinatorial chemistry

1993 • 234 citations

Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports

1988 • 218 citations

Encoded combinatorial peptide libraries containing non-natural amino acids

1993 • 165 citations

Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library

1995 • 161 citations

"Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis

1994 • 143 citations

A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules

1994 • 125 citations

New promise in combinatorial chemistry: synthesis, characterization, and screening of small-molecule libraries in solution

1995 • 125 citations

Synthetic receptor binding elucidated with an encoded combinatorial library

1994 • 116 citations

Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis

1992 • 110 citations

Tagged versus untagged libraries: methods for the generation and screening of combinatorial chemical libraries.

1994 • 106 citations

Combinatorial chemistry — applications of light-directed chemical synthesis

1994 • 86 citations

Chemical synthesis of peptide libraries

1993 • 83 citations

A Solution‐Phase Screening Procedure for the Isolation of Active Compounds from a Library of Molecules

1994 • 78 citations

Creation and functional screening of a multi-usepeptide library.

1994 • 73 citations

Combinatorial Technologies Involving Reiterative Division/Coupling/Recombination: Statistical Considerations

1994 • 64 citations

A novel method for delineating antigenic determinants: Peptide synthesis and radioimmunoassay using the same solid support

1977 • 44 citations

Multiple peptide synthesis using a single support (MPS3)

1990 • 40 citations

The use of light‐directed combinatorial peptide synthesis in epitope mapping

1995 • 34 citations

Chapter 28. The Search for Molecular Diversity (II): Recombinant and Synthetic Randomized Peptide Libraries

1991 • 18 citations

Using Peptoid Libraries [Oligo N-Substituted Glycines] for Drug Discovery

1994 • 16 citations

Synthesis of support‐bound peptides carrying color labels

1994 • 13 citations

Sub‐library composition of peptide libraries: Potential application in screening

1994 • 12 citations

Binary synthesis of multicomponent peptide mixtures by the portioning–mixing technique

1995 • 9 citations

Correction: A new type of synthetic peptide library for identifying ligand-binding activity

1992 • 9 citations

Efficiency and limitations of the ‘portioning-mixing’ peptide synthesis

1993 • 8 citations

The Use of sub-library kits in a new screening strategy

1994 • 4 citations

Computer program facilitating separation of peptides from mixtures prepared by the ‘portioning-mixing’ method

1993 • 3 citations

Portioning-mixing: A multi-purpose technique in peptide synthesis

1993 • 3 citations