Solid-phase organic reactions: A review of the recent literature

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis

1992 • 1,190 citations

Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

1994 • 1,130 citations

Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

1994 • 1,126 citations

Combinatorial synthesis — the design of compound libraries and their application to drug discovery

1995 • 655 citations

Organic Chemistry on Solid Supports

1996 • 646 citations

Solid‐Phase Peptide Synthesis

1969 • 624 citations

A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives

1992 • 441 citations

Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library

1994 • 356 citations

Bromination and lithiation: two important steps in the functionalization of polystyrene resins

1976 • 350 citations

A Strategy for the Solid-Phase Synthesis of Oligosaccharides

1993 • 316 citations

Solid-phase synthesis of oligosaccharides. I. Preparation of the solid support. Poly[p-(1-propen-3-ol-1-yl)styrene]

1971 • 282 citations

The use of insoluble polymer supports in general organic synthesis

1978 • 246 citations

Tetrahedron report number 103

1981 • 239 citations

Solid-Phase Chemical-Enzymic Synthesis of Glycopeptides and Oligosaccharides

1994 • 239 citations

A solid phase protocol of the biginelli dihydropyrimidine synthesis suitable for combinatorial chemistry

1995 • 229 citations

Solid-phase organic synthesis: novelty or fundamental concept?

1976 • 211 citations

Carbon-Carbon Bond-Forming Methods on Solid Support. Utilization of Kenner's "Safety-Catch" Linker

1994 • 207 citations

A Silicon-Based Linker for Traceless Solid-Phase Synthesis

1995 • 205 citations

Straightforward and general method for coupling alcohols to solid supports

1994 • 191 citations

Biaryl synthesis via suzuki coupling on a solid support

1994 • 175 citations

Peptidosteroidal Receptors for Opioid Peptides. Sequence-Selective Binding Using a Synthetic Receptor Library

1994 • 171 citations

Solid-Phase Synthesis of Structurally Diverse 1,4-Benzodiazepine Derivatives Using the Stille Coupling Reaction

1995 • 162 citations

Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library

1995 • 161 citations

Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines: Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library

1995 • 161 citations

Trimethylorthoformate: A mild and effective dehydrating reagent for solution and solid phase imine formation

1995 • 153 citations

"Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis

1994 • 143 citations

An expedient and high-yielding method for the solid-phase synthesis of diverse 1,4-benzodiazepine-2,5-diones

1995 • 142 citations

Methods for Combinatorial Organic Synthesis: The Use of Fast 13C NMR Analysis for Gel Phase Reaction Monitoring

1994 • 137 citations

Simultaneous Solid-Phase Synthesis of .beta.-Turn Mimetics Incorporating Side-Chain Functionality

1994 • 133 citations

Expedient Method for the Solid-Phase Synthesis of Aspartic Acid Protease Inhibitors Directed toward the Generation of Libraries

1995 • 131 citations

Polymer-Supported Solution Synthesis of Oligosaccharides Using a Novel Versatile Linker for the Synthesis of D-Mannopentaose, a Structural Unit of D-Mannans of Pathogenic Yeasts

1995 • 130 citations

Analytical Techniques in Combinatorial Chemistry: MAS CH Correlation in Solvent-Swollen Resin

1995 • 128 citations

New promise in combinatorial chemistry: synthesis, characterization, and screening of small-molecule libraries in solution

1995 • 125 citations

A Novel Procedure for the Synthesis of Libraries Containing Small Organic Molecules

1994 • 125 citations

Combinatorial chemistry

1995 • 124 citations

Synthetic receptor binding elucidated with an encoded combinatorial library

1994 • 116 citations

A solid phase CBZ chloride equivalent — a new matrix specific linker

1995 • 115 citations

A PEGA resin for use in the solid-phase chemical–enzymatic synthesis of glycopeptides

1994 • 115 citations

Solid Phase Chemistry: Direct Monitoring by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry. A Tool for Combinatorial Chemistry

1995 • 110 citations

Automated synthesis of peptide C-terminal aldehydes

1992 • 110 citations

Solid phase synthesis of aryl ethers via the mitsunobu reaction

1995 • 102 citations

Solid-Phase Synthesis of Biaryls via the Stille Reaction

1995 • 100 citations

Phosphatase Catalysis Developed via Combinatorial Organic Chemistry

1995 • 99 citations

Preparation and Screening against Acetylcholinesterase of a Non-Peptide "Indexed" Combinatorial Library

1995 • 97 citations

Multiple simultaneous synthesis of phenolic libraries

1995 • 95 citations

Solution- and Solid-Phase Synthesis of Inhibitors of H. pylori Attachment and E-Selectin-Mediated Leukocyte Adhesion

1994 • 93 citations

A general method for the solid phase synthesis of ureas

1994 • 92 citations

Synthesis of Sequence Specific Phenylacetylene Oligomers on an Insoluble Solid Support

1994 • 92 citations

Solid-phase synthesis of defined 1,4-benzodiazepine-2,5-dione mixtures

1995 • 91 citations

Formation of carbon-carbon bond on solid support: Application of the stille reaction

1994 • 90 citations

Heck reactions in solid phase synthesis

1994 • 89 citations

Formation of CC bond in solid phase synthesis using the heck reaction

1995 • 87 citations

Polymer-supported synthesis of 2,5-disubstituted tetrahydrofurans

1992 • 86 citations

Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy

1994 • 86 citations

Polymer-supported Mitsunobu ether formation and its use in combinatorial chemistry

1995 • 85 citations

A Combinatorial Library Approach to Artificial Receptor Design

1995 • 80 citations

Improved solid phase synthesis of C-terminal peptide aldehydes

1995 • 79 citations

Solid-Phase Synthesis of Highly Substituted Peptoid 1(2H)-Isoquinolinones

1995 • 79 citations

A Solution‐Phase Screening Procedure for the Isolation of Active Compounds from a Library of Molecules

1994 • 78 citations

Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores

1995 • 78 citations

Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination

1995 • 78 citations

Solid-phase synthesis of “small” organic molecules based on thiazolidine scaffold

1995 • 77 citations

Synthesis and biological evaluation of a library containing potentially 1600 amides / esters. A strategy for rapid compound generation and screening.

1994 • 69 citations

A Transition State Analog Inhibitor Combinatorial Library

1995 • 67 citations

A polymer-supported C2-symmetric chiral auxiliary: Preparation of non-racemic 3,5-disubstituted-γ-butyrolactones

1994 • 67 citations

Solid-phase photochemical C-S bond cleavage of thioethers-a new approach to the solid-phase production of non-peptide molecules

1994 • 66 citations

A strategy for urea linked diamine libraries

1995 • 66 citations

A polymer-supported chiral auxiliary applied to the iodolactonization reaction: preparation of .gamma.-butyrolactones

1992 • 64 citations

A surprising observation about Mitsunobu reactions in solid phase synthesis

1994 • 62 citations

Synthetic Ionophores. Encoded Combinatorial Libraries of Cyclen-based Receptors for Cu2+ and Co2+

1995 • 61 citations

Structure determination in combinatorial chemistry: Utilization of Magic Angle Spinning HMQC and TOCSY NMR spectra in the structure determination of Wang-bound lysine

1995 • 60 citations

Polymer-Supported Synthesis of Cyclic Ethers: Electrophilic Cyclization of Isoxazolines

1995 • 60 citations

Regioselectivity in cycloaddition reactions on solid phases

1980 • 57 citations

Post-modification of peptoid side chains: [3+2] cycloaddition of nitrile oxides with alkenes and alkynes on the solid-phase

1994 • 57 citations

Solid Phase Synthesis of Lavendustin A and Analogs

1995 • 55 citations

Solid‐Phase Synthesis of Vinylogous Sulfonyl Peptides

1995 • 54 citations

A novel oxidation‐labile linker for solid‐phase peptide synthesis

1995 • 48 citations

Solid phase synthesis of aryl and benzylpiperazines and their application in combinatorial chemistry

1995 • 46 citations

The solid phase synthesis of dihydro- and tetrahydroisoquinolines

1995 • 44 citations

Rapid optimization of organic reactions on solid phase using the multipin approach: Synthesis of 4-aminoproline analogues by reductive amination

1995 • 42 citations

Solid Phase Synthesis of Aryl and Benzylpiperazines and their Application in Combinatorial Chemistry

1995 • 40 citations

Screening and characterization of estrogenic activity from a hydroxystilbene library

1995 • 38 citations

Catalytic asymmetric synthesis of peptides on polymer support

1994 • 36 citations

The solid phase synthesis of tertiary hydroxyesters from symmetrical diacid chlorides using organomanganese reagents

1980 • 35 citations

NPIT: A new reagent for quantitatively monitoring reactions of amines in combinatorial synthesis

1995 • 34 citations

Preparation of high capacity aminomethyl-polystyrene resin

1995 • 33 citations

Solid-phase synthesis and C-terminal amidation of peptides using a photolabile o-nitrobenzhydrylaminopolystyrene support

1995 • 30 citations

Polymer-supported enzymic synthesis on a preparative scale

1994 • 28 citations

Asymmetrische Synthese von 2‐Alkylcyclohexanonen an festen Trägern

1979 • 27 citations

The Challenge of Preparing and Testing Combinatorial Compound Libraries in the Fast Lane, at the Front End of Drug Development

1994 • 27 citations

Rapid Optimization of Organic Reactions on Solid Phase using the Multipin Approach: Synthesis of 4-Aminoproline Analogues by Reductive Amination

1995 • 25 citations

Diels-Alder Reactions in Polymer Chemistry: Synthesis of Pyridoxine on a Polymeric Backbone

1994 • 21 citations

An improved low racemization solid-phase method for the synthesis of reduced dipeptide (psi CH2NH) bond isosteres.

1993 • 20 citations

Expeditious Synthesis of a Novel C₃‐Symmetric Receptor that Binds Peptides Sequence‐Selectively

1995 • 19 citations