Lamotrigine

Proposal for Revised Classification of Epilepsies and Epileptic Syndromes

1989 • 5,132 citations

The Prevalence and Incidence of Convulsive Disorders in Children

1994 • 672 citations

Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy

1995 • 627 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

Antiepileptic Drugs as a Cause of Worsening Seizures

1998 • 533 citations

The role of glutamate in epilepsy and other CNS disorders.

1994 • 476 citations

Lamotrigine and Seizure Aggravation in Severe Myoclonic Epilepsy

1998 • 459 citations

Lamotrigine for Generalized Seizures Associated with the Lennox–Gastaut Syndrome

1997 • 356 citations

Outcomes of Add‐on Treatment with Lamotrigine in Partial Epilepsy

1993 • 339 citations

Lamotrigine‐Associated Rash: Risk/Benefit Considerations in Adults and Children

1999 • 339 citations

Valproic acid hepatic fatalities. III. U.S. experience since 1986

1996 • 329 citations

Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

1994 • 302 citations

Lamotrigine

1993 • 300 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans

1987 • 273 citations

Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: A record linkage study

1997 • 261 citations

Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

1995 • 255 citations

Sodium valproate acutely inhibits lamotrigine metabolism.

1992 • 254 citations

Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex

1993 • 254 citations

Lamotrigine Monotherapy in Newly Diagnosed Untreated Epilepsy: A Double‐Blind Comparison with Phenytoin

1999 • 242 citations

Lamotrigine Clinical Pharmacokinetics

1993 • 237 citations

Safety Review of Adult Clinical Trial Experience with Lamotrigine

1998 • 226 citations

Valproic Acid

1994 • 226 citations

Lamotrigine in Treatment of 120 Children with Epilepsy

1994 • 218 citations

Lamictal (Lamotrigine) Monotherapy for Typical Absence Seizures in Children

1999 • 218 citations

Controlled Trial of Lamotrigine (Lamictar) for Refractory Partial Seizures

1989 • 208 citations

Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications

1996 • 204 citations

Lamotrigine

1995 • 197 citations

Acute Effects of Lamotrigine (BW430C) in Persons With Epilepsy

1986 • 191 citations

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 187 citations

Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells.

1993 • 179 citations

Intractable Epilepsy in Children. The Efficacy of Lamotrigine Treatment, Including Non-Seizure-Related Benefits

1994 • 177 citations

A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures

1990 • 167 citations

Pharmacokinetic Interactions Between Antiepileptic Drugs

1996 • 160 citations

Carbamazepine Toxicity with Lamotrigine: Pharmacokinetic or Pharmacodynamic Interaction?

1998 • 156 citations

Lamotrigine for the treatment of epilepsy in childhood

1995 • 153 citations

Cerebroprotective Effect of Lamotrigine After Focal Ischemia in Rats

1995 • 148 citations

Utility of the Lethargic (lh/lh) Mouse Model of Absence Seizures in Predicting the Effects of Lamotrigine, Vigabatrin, Tiagabine, Gabapentin, and Topiramate Against Human Absence Seizures

1997 • 148 citations

Safety of Long‐Term Lamotrigine in Epilepsy

1997 • 147 citations

Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam.

1985 • 144 citations

A randomized double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy

1990 • 143 citations

Neurochemical and Behavioral Aspects of Lamotrigine

1991 • 142 citations

Tonic Status Epilepticus precipitated by Intravenous Benzodiazepine in Five Patients with Lennox‐Gastaut Syndrome

1972 • 138 citations

Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data

1997 • 134 citations

Similar potency of carbamazepine, oxcarbazepine, and lamotrigine in inhibiting the release of glutamate and other neurotransmitters

1995 • 134 citations

Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy

1987 • 133 citations

Excitatory amino acids in epilepsy and potential novel therapies

1992 • 131 citations

Pharmacokinetics and safety of lamotrigine (Lamictal®) in patients with epilepsy

1991 • 130 citations

Clinical Pharmacology of Lamotrigine

1991 • 126 citations

A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children

1999 • 124 citations

Bidirectional interaction of valproate and lamotrigine in healthy subjects*

1996 • 123 citations

The Efficacy of Lamotrigine in Children and Adolescents with Refractory Generalized Epilepsy: A Randomized, Double‐Blind, Crossover Study

1998 • 123 citations

Inhibition of N-type calcium currents by lamotrigine in rat amygdalar neurones

1996 • 122 citations

Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin

1997 • 120 citations

Lamotrigine as an Add-On Drug in the Management of Lennox-Gastaut Syndrome

1992 • 118 citations

Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11 -epoxide

1992 • 117 citations

Lamotrigine: Pharmacokinetics

1997 • 115 citations

Aggressive Behaviour in Intellectually Challenged Patients with Epilepsy Treated with Lamotrigine

1998 • 106 citations

Human Safety of Lamotrigine

1991 • 105 citations

Concentration‐Effect and Concentration‐Toxicity Relations with Lamotrigine: A Prospective Study

1996 • 105 citations

Felbamate in the Treatment of Lennox‐Gastaut Syndrome: Results of a 12‐Month Open‐Label Study Following a Randomized Clinical Trial

1993 • 101 citations

Rash in Adult and Pediatric Patients Treated with Lamotrigine

1998 • 90 citations

Pharmacokinetic Interactions Between Lamotrigine and Other Antiepileptic Drugs in Children with Intractable Epilepsy

1996 • 88 citations

Antiepileptic Drug Cellular Mechanisms of Action: Where Does Lamotrigine Fit In?

1997 • 86 citations

The Influence of Dosage, Age, and Comedication on Steady State Plasma Lamotrigine Concentrations in Epileptic Children

1997 • 86 citations

Clinical Pharmacokinetics of Newer Antiepileptic Drugs

1996 • 86 citations

The potential for increasing seizure frequency, relapse, and appearance of new seizure types with vigabatrin.

1993 • 85 citations

Drug points: Fulminant hepatic failure induced by lamotrigine

1995 • 83 citations

A Comparative Review of the Adverse Effects of Anticonvulsants in Children with Epilepsy

1996 • 80 citations

Lamotrigine protects against kainate but not ibotenate lesions in rat striatum

1990 • 77 citations

Effect of carbamazepine, oxcarbazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum

1996 • 77 citations

The Tolerability of Lamotrigine in Children

2000 • 70 citations

Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug, Lamotrigine

1991 • 70 citations

The efficacy of lamotrigine on seizure control in 34 children, adolescents and young adults with intellectual and physical disability

1995 • 69 citations

Lamotrigine Adjunctive Therapy in Childhood Epileptic Encephalopathy (the Lennox Gastaut Syndrome)

1997 • 69 citations

The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy.

1986 • 68 citations

Lamotrigine Serum Concentration-to-Dose Ratio: Influence of Age and Concomitant Antiepileptic Drugs and Dosage Implications

1999 • 67 citations

Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in rats

1998 • 66 citations

Pharmacokinetics of lamotrigine in patients with renal impairment: influence of haemodialysis.

1993 • 65 citations

Rechallenge with lamotrigine after initial rash

1995 • 64 citations

Carbamazepine and Lamotrigine in Healthy Volunteers: Relevance to Early Tolerance and Clinical Trial Dosage

1993 • 64 citations

Lamotrigine-induced rash in children

1996 • 62 citations

Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid

1997 • 61 citations

Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine

1990 • 60 citations

Lamotrigine: Preliminary clinical observations on pharmacokinetics and interactions with traditional antiepileptic drugs

1992 • 59 citations

Long-Term Tolerability, Pharmacokinetic and Preliminary Efficacy Study of Lamotrigine in Patients with Resistant Partial Seizures

1989 • 55 citations

Therapeutic interaction of lamotrigine and sodium valproate in intractable myoclonic epilepsy

1994 • 54 citations

Fortnightly review: Epilepsy in childhood

1997 • 54 citations

Long-term safety and efficacy of lamotrigine (Lamictal®) in paediatric patients with epilepsy

1997 • 53 citations

Influence of concurrent antiepileptic medication on the pharmacokinetics of lamotrigine as add‐on therapy in epileptic children

1996 • 51 citations

Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine.

1991 • 51 citations

Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat

1993 • 49 citations

Pharmacokinetics of Lamotrigine in Children in the Absence of other Antiepileptic Drugs

1999 • 46 citations

Alternative single anticonvulsant drug therapy for refractory epilepsy

1986 • 45 citations

Electrophysiological effects of propafenone in untreated and propafenone‐pretreated guinea‐pig atrial and ventricular muscle fibres

1985 • 45 citations

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy

1997 • 44 citations

Use of Lamotrigine in Lennox-Gastaut and Related Epilepsy Syndromes

1997 • 44 citations

Methsuximide Lowers Lamotrigine Blood Levels: A Pharmacokinetic Antiepileptic Drug Interaction

2000 • 42 citations

Lamotrigine childhood overdose

1998 • 42 citations

Lamotrigine in Rett syndrome: Treatment experience from a pilot study

1998 • 41 citations

Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies

1987 • 40 citations

Lamotrigine Plasma Concentrations in Children and Adults

1997 • 40 citations

Methods of assessment of antiepileptic drugs.

1981 • 40 citations

Effect of lamotrigine on EEG paroxysmal abnormalities and background activity: a computerized analysis

1996 • 40 citations

Successful re-introduction of lamotrigine after initial rash

2000 • 38 citations

Effects of Lamotrigine on Electrically Induced Afterdischarge Duration in Anaesthetised Rat, Dog, and Marmoset

1989 • 38 citations

Lamotrigine in Resistant Childhood Epilepsy

1993 • 37 citations

Use of New Antiepileptic Drugs in the Treatment of Childhood Epilepsy

1999 • 33 citations

Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial

1997 • 32 citations

Lamotrigine Hypersensitivity in Childhood Epilepsy

1998 • 32 citations

Lamotrigine Therapy in Juvenile Neuronal Ceroid Lipofuscinosis

1999 • 31 citations

Lamotrigine Concentrations in Human Serum, Brain Tissue, and Tumor Tissue

1999 • 30 citations

Cognitive impairment--is it inevitable?

1994 • 29 citations

Single dose pharmacokinetics of carbamazepine-10,11-epoxide in patients on lamotrigine monotherapy

1994 • 29 citations

No Increase in Carbamazepine-10,11-Epoxide During Addition of Lamotrigine Treatment in Children

1997 • 21 citations

Lamotrigine Treatment in Childhood Drug Resistant Epilepsy

1998 • 20 citations

Approaches to Reducing the Incidence of Lamotrigine-Induced Rash

2000 • 19 citations

TOPIRAMATE DECREASES LAMOTRIGIN CONCENTRATIONS

1999 • 19 citations

Treatment of Lennox-Gastaut Syndrome

1998 • 17 citations

Lamotrigine pharmacokinetics in patients receiving felbamate

1997 • 16 citations

Three-Year Efficacy and Tolerability of Add-On Lamotrigine in Treatment-Resistant Epileptic Children

1996 • 15 citations

Investigational Antiepileptic Drugs for the Treatment of Childhood Seizure Disorders: A Review of Efficacy and Safety

1994 • 15 citations

Treatment With High Doses of Lamotrigine in Children and Adolescents With Refractory Seizures

1997 • 15 citations

Influence of Lamotrigine Addition on Computerized Background EEG Parameters in Severe Epileptogenic Encephalopathies

1994 • 13 citations

Clinical pharmacology‐mutual benefits from greater collaboration between academia and the pharmaceutical industry.

1991 • 11 citations

New Antiepileptic Drugs for Children: Felbamate, Gabapentin, Lamotrigine, and Vigabatrin

1994 • 11 citations

Lamotrigine and severe skin eruptions

1998 • 2 citations

Neurological Nursing

1969 • 1 citations