Lamotrigine Clinical Pharmacokinetics

Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug

1986 • 558 citations

Lamotrigine

1993 • 300 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans

1987 • 273 citations

Sodium valproate acutely inhibits lamotrigine metabolism.

1992 • 254 citations

Controlled Trial of Lamotrigine (Lamictar) for Refractory Partial Seizures

1989 • 208 citations

New Anticonvulsant Drugs

1994 • 191 citations

Acute Effects of Lamotrigine (BW430C) in Persons With Epilepsy

1986 • 191 citations

Lamotrigine

1992 • 184 citations

Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy

1989 • 175 citations

A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures

1990 • 167 citations

Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam.

1985 • 144 citations

A randomized double-blind placebo-controlled add-on trial of lamotrigine in patients with severe epilepsy

1990 • 143 citations

Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy

1987 • 133 citations

Pharmacokinetics and safety of lamotrigine (Lamictal®) in patients with epilepsy

1991 • 130 citations

Clinical Pharmacology of Lamotrigine

1991 • 126 citations

Lamotrigine-induced carbamazepine toxicity: an interaction with carbamazepine-10,11 -epoxide

1992 • 117 citations

Human Safety of Lamotrigine

1991 • 105 citations

In vitro N-glucuronidation of a novel antiepileptic drug, lamotrigine, by human liver microsomes.

1992 • 71 citations

Use of thermospray liquid chromatography-mass spectrometry to aid in the identification of urinary metabolites of a novel antiepileptic drug, Lamotrigine

1991 • 70 citations

The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy.

1986 • 68 citations

The pharmacokinetics of lamotrigine (BW430C) in healthy subjects with unconjugated hyperbilirubinaemia (Gilbert's syndrome).

1989 • 68 citations

Antiepileptic Drug Intoxication: Factors and Their Significance

1991 • 67 citations

An assessment of serum and red blood cell folate concentrations in patients with epilepsy on lamotrigine therapy

1992 • 65 citations

Kinetic effects of multiple oral doses of acetaminophen on a single oral dose of lamotrigine

1990 • 60 citations

Lamotrigine: Preliminary clinical observations on pharmacokinetics and interactions with traditional antiepileptic drugs

1992 • 59 citations

Validation of a radioimmunoassay for the determination of human plasma concentrations of lamotrigine

1990 • 56 citations

Long-Term Tolerability, Pharmacokinetic and Preliminary Efficacy Study of Lamotrigine in Patients with Resistant Partial Seizures

1989 • 55 citations

Isolation and characterization of a novel quaternary ammonium-linked glucuronide of lamotrigine.

1991 • 51 citations

A Liquid Chromatographic Assay Using a High-Speed Column for the Determination of Lamotrigine, a New Antiepileptic Drug, in Human Plasma

1992 • 49 citations

Performance analysis of a reversed-phase liquid chromatographic assay of lamotrigine in plasma using solvent-demixing extraction

1991 • 47 citations

Lamotrigine pharmacokinetics : oral and IV infusion in man

1988 • 46 citations

Immunofluorometric Assay for Lamotrigine (Lamictal) in Human Plasma

1991 • 39 citations

Analysis of lamotrigine and lamotrigine 2-N-glucuronide in guinea pig blood and urine by reserved-phase ion-pairing liquid chromatography

1991 • 29 citations

Alkylamine/Phosphoric Acid as a Universal Buffer System for Basic and Acidic Mobile Phases in HPLC

1988 • 23 citations

Pharmacokinetics of lamotrigine

1992 • 14 citations

Clinical pharmacology‐mutual benefits from greater collaboration between academia and the pharmaceutical industry.

1991 • 11 citations