Control of immune homeostasis by naturally arising regulatory CD4+ T cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

2003 • 933 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

2002 • 779 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses

2003 • 531 citations

Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

2003 • 523 citations

Control of intestinal inflammation by regulatory T cells

2001 • 496 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

CD25+ cell depletion hastens the onset of severe disease in collagen‐induced arthritis

2003 • 313 citations

Pancreatic Lymph Node-Derived CD4+CD25+ Treg Cells

2002 • 312 citations

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

1998 • 299 citations

CD25⁺CD4⁺regulatory T cells suppress CD4⁺T cell‐mediated pulmonary hyperinflammation driven byPneumocystis cariniiin immunodeficient mice

2002 • 276 citations

Functional expression of B7/BB1 on activated T lymphocytes.

1993 • 271 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans

2002 • 236 citations

CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

2003 • 230 citations

Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses

2002 • 209 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD4+25+ T cells to allow an effective graft-versus-leukemia response

2003 • 199 citations

Control of T cell hyperactivation in IL-2-deficient mice by CD4+CD25- and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms

2001 • 183 citations

Immune Elimination ofLeishmania majorin Mice: Implications for Immune Memory, Vaccination, and Reactivation Disease

2001 • 176 citations

Role of GITR in activation response of T lymphocytes

2002 • 169 citations

Regulation of Murine Inflammatory Bowel Disease by CD25+ and CD25− CD4+ Glucocorticoid-Induced TNF Receptor Family-Related Gene+ Regulatory T Cells

2003 • 142 citations

B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro

1993 • 117 citations

Administration of anti‐interleukin‐2 receptor α antibody in vivo induces localized autoimmune disease

1996 • 101 citations

X-chromosome inactivation analysis in a female carrier of FOXP3 mutation

2002 • 95 citations

High antigen dose and activated dendritic cells enable Th cells to escape regulatory T cell‐mediated suppression in vitro

2003 • 90 citations

Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation

1995 • 78 citations

Transcription factors in autoimmunity

2003 • 58 citations

Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 46 citations

Escherichia coli heat‐labile enterotoxin B subunit prevents autoimmune arthritis through induction of regulatory CD4+ T cells

2002 • 43 citations

Endogenous CD4+BV8S2− T cells from TG BV8S2+ donors confer complete protection against spontaneous experimental encephalomyelitis (Sp‐EAE) in TCR transgenic, RAG^−/− mice

2002 • 12 citations